| Rank | Player | Opponent | Sched Date | ATT | COMP | INT | NET | Average | TD | CM | Position | Class |
| 1 | Colt Brennan, Hawaii | San Jose St. | 12-OCT-07 | 75 | 44 | 4 | 545 | 12.39 | 4 | 0 | QB | SR |
| 2 | Graham Harrell, Texas Tech | Oklahoma | 17-NOV-07 | 72 | 47 | 2 | 420 | 8.94 | 2 | 0 | QB | JR |
| 3 | Graham Harrell, Texas Tech | Virginia | 01-JAN-08 | 69 | 44 | 0 | 407 | 9.25 | 3 | 0 | QB | JR |
| 3 | Graham Harrell, Texas Tech | Missouri | 20-OCT-07 | 69 | 44 | 4 | 397 | 9.02 | 1 | 0 | QB | JR |
| 5 | Graham Harrell, Texas Tech | Oklahoma St. | 22-SEP-07 | 67 | 46 | 0 | 646 | 14.04 | 5 | 0 | QB | JR |
| 6 | Chase Clement, Rice | Tulsa | 24-NOV-07 | 66 | 40 | 1 | 541 | 13.53 | 3 | 0 | QB | JR |
| 6 | Cullen Harper, Clemson | Virginia Tech | 06-OCT-07 | 66 | 38 | 2 | 372 | 9.79 | 2 | 1 | QB | JR |
| 8 | Brian Brohm, Louisville | Syracuse | 22-SEP-07 | 65 | 45 | 2 | 555 | 12.33 | 4 | 0 | QB | SR |
| 9 | Graham Harrell, Texas Tech | UTEP | 08-SEP-07 | 64 | 48 | 1 | 484 | 10.08 | 4 | 0 | QB | JR |
| 9 | Daniel Meager, North Texas | Southern Methodist | 08-SEP-07 | 64 | 46 | 3 | 601 | 13.07 | 3 | 0 | QB | SR |
| 11 | Chase Holbrook, New Mexico St. | New Mexico | 08-SEP-07 | 63 | 47 | 2 | 473 | 10.06 | 4 | 0 | QB | JR |
| 12 | Graham Harrell, Texas Tech | Colorado | 27-OCT-07 | 62 | 46 | 4 | 431 | 9.37 | 3 | 0 | QB | JR |
| 12 | Andre Woodson, Kentucky | Tennessee | 24-NOV-07 | 62 | 39 | 2 | 430 | 11.03 | 6 | 0 | QB | SR |
| 14 | Colt Brennan, Hawaii | Louisiana Tech | 08-SEP-07 | 61 | 43 | 1 | 548 | 12.74 | 4 | 0 | QB | SR |
| 14 | Willie Tuitama, Arizona | California | 22-SEP-07 | 61 | 42 | 2 | 309 | 7.36 | 1 | 0 | QB | JR |
| 14 | Daniel Meager, North Texas | Fla. Atlantic | 22-SEP-07 | 61 | 38 | 3 | 301 | 7.92 | 1 | 0 | QB | SR |
| 17 | Martin Hankins, Memphis | Mississippi | 01-SEP-07 | 60 | 41 | 4 | 343 | 8.37 | 1 | 1 | QB | SR |
| 17 | Blake Szymanski, Baylor | Colorado | 06-OCT-07 | 60 | 36 | 2 | 410 | 11.39 | 1 | 0 | QB | JR |
| 17 | Martin Hankins, Memphis | East Caro. | 03-NOV-07 | 60 | 34 | 2 | 416 | 12.24 | 4 | 1 | QB | SR |
| 17 | Curtis Painter, Purdue | Ohio St. | 06-OCT-07 | 60 | 31 | 0 | 268 | 8.65 | 1 | 0 | QB | JR |
| 21 | Graham Harrell, Texas Tech | Southern Methodist | 03-SEP-07 | 59 | 44 | 0 | 419 | 9.52 | 4 | 0 | QB | JR |
| 21 | Martin Hankins, Memphis | Southern Methodist | 24-NOV-07 | 59 | 30 | 1 | 336 | 11.2 | 4 | 0 | QB | SR |
| 21 | T.C. Ostrander, Stanford | UCLA | 01-SEP-07 | 59 | 27 | 0 | 346 | 12.81 | 2 | 0 | QB | SR |
| 24 | Chase Holbrook, New Mexico St. | Utah St. | 17-NOV-07 | 58 | 42 | 2 | 367 | 8.74 | 1 | 0 | QB | JR |
| 24 | C.J. Bacher, Northwestern | Minnesota | 13-OCT-07 | 58 | 41 | 0 | 470 | 11.46 | 4 | 0 | QB | JR |
| 24 | Brian Brohm, Louisville | Utah | 05-OCT-07 | 58 | 39 | 0 | 467 | 11.97 | 4 | 0 | QB | SR |
| 24 | Chase Clement, Rice | UTEP | 03-NOV-07 | 58 | 32 | 3 | 395 | 12.34 | 6 | 0 | QB | JR |
| 24 | Joe Ganz, Nebraska | Colorado | 23-NOV-07 | 58 | 31 | 3 | 484 | 15.61 | 4 | 2 | QB | JR |
| 29 | Giovanni Vizza, North Texas | La.-Lafayette | 06-OCT-07 | 57 | 35 | 3 | 383 | 10.94 | 3 | 0 | QB | FR |
| 29 | Max Hall, BYU | Tulsa | 15-SEP-07 | 57 | 34 | 2 | 537 | 15.79 | 4 | 0 | QB | SO |
| 29 | Daniel Raudabaugh, Miami (Ohio) | Temple | 20-OCT-07 | 57 | 33 | 2 | 314 | 9.52 | 2 | 0 | QB | SO |
| 29 | Josh Freeman, Kansas St. | Auburn | 01-SEP-07 | 57 | 32 | 2 | 268 | 8.38 | 0 | 0 | QB | SO |
| 29 | Trevor Vittatoe, UTEP | Rice | 03-NOV-07 | 57 | 30 | 0 | 373 | 12.43 | 5 | 0 | QB | FR |
| 34 | Alex Brink, Washington St. | Arizona | 29-SEP-07 | 56 | 35 | 1 | 347 | 9.91 | 3 | 0 | QB | SR |
| 34 | Dan LeFevour, Central Mich. | Purdue | 15-SEP-07 | 56 | 35 | 1 | 364 | 10.4 | 2 | 1 | QB | SO |
| 34 | Paul Smith, Tulsa | UCF | 20-OCT-07 | 56 | 34 | 4 | 316 | 9.29 | 3 | 0 | QB | SR |
| 34 | Matt Ryan, Boston College | Maryland | 10-NOV-07 | 56 | 33 | 2 | 421 | 12.76 | 3 | 0 | QB | SR |
| 34 | Daniel Evans, North Carolina St. | Wake Forest | 17-NOV-07 | 56 | 24 | 3 | 286 | 11.92 | 1 | 1 | QB | JR |
| 39 | Trevor Vittatoe, UTEP | East Caro. | 13-OCT-07 | 55 | 38 | 1 | 409 | 10.76 | 3 | 0 | QB | FR |
| 39 | Kevin O'Connell, San Diego St. | BYU | 01-DEC-07 | 55 | 33 | 1 | 288 | 8.73 | 1 | 0 | QB | SR |
| 39 | Paul Smith, Tulsa | UCF | 01-DEC-07 | 55 | 28 | 3 | 426 | 15.21 | 3 | 0 | QB | SR |
| 42 | Chase Daniel, Missouri | Illinois | 01-SEP-07 | 54 | 37 | 0 | 359 | 9.7 | 3 | 0 | QB | JR |
| 42 | Sam Keller, Nebraska | Southern California | 15-SEP-07 | 54 | 36 | 2 | 389 | 10.81 | 2 | 1 | QB | SR |
| 42 | Rusty Smith, Fla. Atlantic | La.-Monroe | 27-OCT-07 | 54 | 35 | 2 | 317 | 9.06 | 1 | 0 | QB | SO |
| 42 | Curtis Painter, Purdue | Central Mich. | 26-DEC-07 | 54 | 35 | 2 | 546 | 15.6 | 3 | 0 | QB | JR |
| 42 | Chase Clement, Rice | Tulane | 17-NOV-07 | 54 | 34 | 0 | 345 | 10.15 | 4 | 0 | QB | JR |
| 42 | Dan LeFevour, Central Mich. | Akron | 23-NOV-07 | 54 | 33 | 2 | 382 | 11.58 | 2 | 0 | QB | SO |
| 42 | Matt Grothe, South Fla. | Cincinnati | 03-NOV-07 | 54 | 31 | 4 | 382 | 12.32 | 1 | 0 | QB | SO |
| 42 | Giovanni Vizza, North Texas | Florida Int'l | 01-DEC-07 | 54 | 31 | 2 | 253 | 8.16 | 1 | 0 | QB | FR |
| 42 | C.J. Bacher, Northwestern | Iowa | 03-NOV-07 | 54 | 27 | 3 | 264 | 9.78 | 1 | 0 | QB | JR |
| 42 | Nathan Enderle, Idaho | Northern Ill. | 22-SEP-07 | 54 | 27 | 3 | 423 | 15.67 | 2 | 0 | QB | SO |
| 52 | Colt Brennan, Hawaii | Boise St. | 23-NOV-07 | 53 | 40 | 2 | 495 | 12.38 | 5 | 0 | QB | SR |
| 52 | Cody Hawkins, Colorado | Florida St. | 15-SEP-07 | 53 | 34 | 2 | 306 | 9 | 1 | 0 | QB | FR |
| 52 | Willie Tuitama, Arizona | New Mexico | 15-SEP-07 | 53 | 30 | 1 | 446 | 14.87 | 3 | 0 | QB | JR |
| 52 | John Parker Wilson, Alabama | Florida St. | 29-SEP-07 | 53 | 28 | 0 | 240 | 8.57 | 2 | 0 | QB | JR |
| 52 | Matt Ryan, Boston College | Florida St. | 03-NOV-07 | 53 | 26 | 3 | 415 | 15.96 | 2 | 0 | QB | SR |
| 57 | Chase Holbrook, New Mexico St. | Hawaii | 27-OCT-07 | 52 | 37 | 2 | 328 | 8.86 | 1 | 0 | QB | JR |
| 57 | Chase Clement, Rice | Southern Methodist | 10-NOV-07 | 52 | 35 | 1 | 364 | 10.4 | 2 | 0 | QB | JR |
| 57 | Matt Ryan, Boston College | Virginia Tech | 01-DEC-07 | 52 | 33 | 2 | 305 | 9.24 | 0 | 0 | QB | SR |
| 57 | Mike Teel, Rutgers | Connecticut | 03-NOV-07 | 52 | 32 | 1 | 343 | 10.72 | 0 | 0 | QB | JR |
| 57 | Matt Ryan, Boston College | Wake Forest | 01-SEP-07 | 52 | 32 | 2 | 408 | 12.75 | 5 | 0 | QB | SR |
| 57 | Chase Holbrook, New Mexico St. | Fresno St. | 30-NOV-07 | 52 | 31 | 0 | 323 | 10.42 | 1 | 0 | QB | JR |
| 57 | Ben Mauk, Cincinnati | Southern Miss. | 22-DEC-07 | 52 | 30 | 3 | 334 | 11.13 | 4 | 0 | QB | SR |
| 57 | Max Hall, BYU | UCLA | 08-SEP-07 | 52 | 30 | 1 | 391 | 13.03 | 2 | 0 | QB | SO |
| 57 | Omar Haugabook, Troy | Florida | 08-SEP-07 | 52 | 29 | 1 | 283 | 9.76 | 2 | 0 | QB | SR |
| 57 | Willie Tuitama, Arizona | Arizona St. | 01-DEC-07 | 52 | 28 | 2 | 272 | 9.71 | 2 | 0 | QB | JR |
| 57 | Matt Ryan, Boston College | Virginia Tech | 25-OCT-07 | 52 | 25 | 2 | 285 | 11.4 | 2 | 0 | QB | SR |
| 68 | Willie Tuitama, Arizona | Washington | 27-OCT-07 | 51 | 38 | 1 | 510 | 13.42 | 5 | 1 | QB | JR |
| 68 | Josh Freeman, Kansas St. | Oklahoma St. | 20-OCT-07 | 51 | 36 | 0 | 404 | 11.22 | 3 | 1 | QB | SO |
| 68 | Matt Ryan, Boston College | Army | 22-SEP-07 | 51 | 35 | 2 | 356 | 10.17 | 3 | 1 | QB | SR |
| 68 | Tyler Sheehan, Bowling Green | Minnesota | 01-SEP-07 | 51 | 34 | 0 | 388 | 11.41 | 2 | 1 | QB | SO |
| 68 | Blake Szymanski, Baylor | Texas St. | 15-SEP-07 | 51 | 31 | 2 | 411 | 13.26 | 5 | 0 | QB | JR |
| 68 | Wesley Carroll, Mississippi St. | Arkansas | 17-NOV-07 | 51 | 29 | 4 | 421 | 14.52 | 4 | 0 | QB | FR |
| 68 | Tim Hiller, Western Mich. | Indiana | 08-SEP-07 | 51 | 28 | 1 | 343 | 12.25 | 3 | 0 | QB | SO |
| 68 | Blake Mitchell, South Carolina | Arkansas | 03-NOV-07 | 51 | 27 | 0 | 364 | 13.48 | 2 | 0 | QB | SR |
| 68 | Kevin O'Connell, San Diego St. | TCU | 24-NOV-07 | 51 | 26 | 0 | 366 | 14.08 | 2 | 0 | QB | SR |
| 68 | Kellen Lewis, Indiana | Illinois | 22-SEP-07 | 51 | 26 | 1 | 263 | 10.12 | 2 | 0 | QB | SO |
| 68 | Bret Meyer, Iowa St. | Nebraska | 29-SEP-07 | 51 | 26 | 3 | 281 | 10.81 | 0 | 0 | QB | SR |
| 79 | Colt Brennan, Hawaii | Washington | 01-DEC-07 | 50 | 42 | 0 | 442 | 10.52 | 5 | 0 | QB | SR |
| 79 | Giovanni Vizza, North Texas | Navy | 10-NOV-07 | 50 | 40 | 2 | 478 | 11.95 | 8 | 0 | QB | FR |
| 79 | Andre Woodson, Kentucky | Florida | 20-OCT-07 | 50 | 35 | 0 | 415 | 11.86 | 5 | 0 | QB | SR |
| 79 | Tyler Sheehan, Bowling Green | Michigan St. | 08-SEP-07 | 50 | 32 | 2 | 295 | 9.22 | 1 | 0 | QB | SO |
| 79 | D.J. Lenehan, Toledo | Buffalo | 13-OCT-07 | 50 | 32 | 1 | 307 | 9.59 | 3 | 0 | QB | FR |
| 79 | Andre Woodson, Kentucky | Florida St. | 31-DEC-07 | 50 | 32 | 1 | 358 | 11.19 | 4 | 0 | QB | SR |
| 79 | C.J. Bacher, Northwestern | Duke | 15-SEP-07 | 50 | 30 | 2 | 368 | 12.27 | 0 | 0 | QB | JR |
| 79 | Daniel Raudabaugh, Miami (Ohio) | Central Mich. | 01-DEC-07 | 50 | 29 | 2 | 254 | 8.76 | 1 | 0 | QB | SO |
| 79 | Rob Kass, East Caro. | North Carolina St. | 20-OCT-07 | 50 | 28 | 1 | 254 | 9.07 | 1 | 0 | QB | SO |
| 79 | Alex Brink, Washington St. | Arizona St. | 06-OCT-07 | 50 | 27 | 1 | 369 | 13.67 | 2 | 0 | QB | SR |
| 79 | Harrison Beck, North Carolina St. | Boston College | 08-SEP-07 | 50 | 26 | 5 | 321 | 12.35 | 0 | 0 | QB | SO |
| 79 | Joe Ganz, Nebraska | Kansas | 03-NOV-07 | 50 | 25 | 4 | 405 | 16.2 | 4 | 1 | QB | JR |
| 79 | Corey Leonard, Arkansas St. | North Texas | 15-NOV-07 | 50 | 25 | 2 | 305 | 12.2 | 2 | 0 | QB | SO |
| 92 | Chase Daniel, Missouri | Kansas | 24-NOV-07 | 49 | 40 | 0 | 361 | 9.03 | 3 | 0 | QB | JR |
| 92 | Curtis Painter, Purdue | Eastern Ill. | 08-SEP-07 | 49 | 38 | 0 | 348 | 9.16 | 6 | 0 | QB | JR |
| 92 | Chase Holbrook, New Mexico St. | Idaho | 20-OCT-07 | 49 | 36 | 0 | 404 | 11.22 | 3 | 0 | QB | JR |
| 92 | Chase Holbrook, New Mexico St. | Nevada | 02-NOV-07 | 49 | 35 | 0 | 407 | 11.63 | 4 | 0 | QB | JR |
| 92 | Matt Ryan, Boston College | Notre Dame | 13-OCT-07 | 49 | 32 | 1 | 291 | 9.09 | 2 | 0 | QB | SR |
| 92 | Colt Brennan, Hawaii | Idaho | 29-SEP-07 | 49 | 30 | 5 | 369 | 12.3 | 3 | 0 | QB | SR |
| 92 | Chase Holbrook, New Mexico St. | San Jose St. | 10-NOV-07 | 49 | 30 | 3 | 318 | 10.6 | 2 | 0 | QB | JR |
| 92 | C.J. Bacher, Northwestern | Illinois | 17-NOV-07 | 49 | 29 | 2 | 310 | 10.69 | 2 | 1 | QB | JR |
| 92 | Omar Haugabook, Troy | La.-Monroe | 29-SEP-07 | 49 | 29 | 2 | 288 | 9.93 | 2 | 0 | QB | SR |
| 92 | Todd Reesing, Kansas | Missouri | 24-NOV-07 | 49 | 28 | 2 | 349 | 12.46 | 2 | 0 | QB | JR |
| 92 | Tyler Donovan, Wisconsin | Illinois | 06-OCT-07 | 49 | 27 | 2 | 392 | 14.52 | 2 | 0 | QB | SR |
| 92 | Nate Davis, Ball St. | Rutgers | 05-JAN-08 | 49 | 25 | 0 | 291 | 11.64 | 3 | 0 | QB | SO |