| Rank | Player | Opponent | Sched Date | ATT | COMP | INT | NET | Average | TD | CM | Position | Class |
| 1 | Graham Harrell, Texas Tech | Oklahoma St. | 22-SEP-07 | 67 | 46 | 0 | 646 | 14.04 | 5 | 0 | QB | JR |
| 2 | Daniel Meager, North Texas | Southern Methodist | 08-SEP-07 | 64 | 46 | 3 | 601 | 13.07 | 3 | 0 | QB | SR |
| 3 | Brian Brohm, Louisville | Syracuse | 22-SEP-07 | 65 | 45 | 2 | 555 | 12.33 | 4 | 0 | QB | SR |
| 4 | Colt Brennan, Hawaii | Louisiana Tech | 08-SEP-07 | 61 | 43 | 1 | 548 | 12.74 | 4 | 0 | QB | SR |
| 5 | Curtis Painter, Purdue | Central Mich. | 26-DEC-07 | 54 | 35 | 2 | 546 | 15.6 | 3 | 0 | QB | JR |
| 6 | Colt Brennan, Hawaii | San Jose St. | 12-OCT-07 | 75 | 44 | 4 | 545 | 12.39 | 4 | 0 | QB | SR |
| 7 | Chase Clement, Rice | Tulsa | 24-NOV-07 | 66 | 40 | 1 | 541 | 13.53 | 3 | 0 | QB | JR |
| 8 | Max Hall, BYU | Tulsa | 15-SEP-07 | 57 | 34 | 2 | 537 | 15.79 | 4 | 0 | QB | SO |
| 9 | C.J. Bacher, Northwestern | Michigan St. | 06-OCT-07 | 48 | 38 | 0 | 520 | 13.68 | 5 | 0 | QB | JR |
| 10 | Willie Tuitama, Arizona | Washington | 27-OCT-07 | 51 | 38 | 1 | 510 | 13.42 | 5 | 1 | QB | JR |
| 10 | Joe Ganz, Nebraska | Kansas St. | 10-NOV-07 | 40 | 30 | 0 | 510 | 17 | 7 | 0 | QB | JR |
| 12 | Colt Brennan, Hawaii | Boise St. | 23-NOV-07 | 53 | 40 | 2 | 495 | 12.38 | 5 | 0 | QB | SR |
| 13 | Graham Harrell, Texas Tech | UTEP | 08-SEP-07 | 64 | 48 | 1 | 484 | 10.08 | 4 | 0 | QB | JR |
| 13 | Joe Ganz, Nebraska | Colorado | 23-NOV-07 | 58 | 31 | 3 | 484 | 15.61 | 4 | 2 | QB | JR |
| 15 | Giovanni Vizza, North Texas | Navy | 10-NOV-07 | 50 | 40 | 2 | 478 | 11.95 | 8 | 0 | QB | FR |
| 16 | Chase Holbrook, New Mexico St. | New Mexico | 08-SEP-07 | 63 | 47 | 2 | 473 | 10.06 | 4 | 0 | QB | JR |
| 17 | C.J. Bacher, Northwestern | Minnesota | 13-OCT-07 | 58 | 41 | 0 | 470 | 11.46 | 4 | 0 | QB | JR |
| 18 | Alex Brink, Washington St. | San Diego St. | 08-SEP-07 | 47 | 38 | 1 | 469 | 12.34 | 5 | 0 | QB | SR |
| 19 | Brian Brohm, Louisville | Utah | 05-OCT-07 | 58 | 39 | 0 | 467 | 11.97 | 4 | 0 | QB | SR |
| 20 | Graham Harrell, Texas Tech | Texas | 10-NOV-07 | 48 | 36 | 1 | 466 | 12.94 | 5 | 2 | QB | JR |
| 21 | Rusty Smith, Fla. Atlantic | Minnesota | 15-SEP-07 | 44 | 27 | 0 | 463 | 17.15 | 5 | 0 | QB | SO |
| 22 | Paul Smith, Tulsa | BYU | 15-SEP-07 | 35 | 21 | 1 | 454 | 21.62 | 5 | 0 | QB | SR |
| 23 | Alex Brink, Washington St. | Stanford | 10-NOV-07 | 47 | 32 | 0 | 449 | 14.03 | 1 | 0 | QB | SR |
| 24 | Willie Tuitama, Arizona | New Mexico | 15-SEP-07 | 53 | 30 | 1 | 446 | 14.87 | 3 | 0 | QB | JR |
| 25 | Kevin O'Connell, San Diego St. | Portland St. | 22-SEP-07 | 31 | 19 | 0 | 443 | 23.32 | 5 | 0 | QB | SR |
| 26 | Colt Brennan, Hawaii | Washington | 01-DEC-07 | 50 | 42 | 0 | 442 | 10.52 | 5 | 0 | QB | SR |
| 27 | Paul Smith, Tulsa | Rice | 24-NOV-07 | 39 | 22 | 1 | 441 | 20.05 | 5 | 0 | QB | SR |
| 28 | Sam Keller, Nebraska | Ball St. | 22-SEP-07 | 37 | 29 | 1 | 438 | 15.1 | 3 | 0 | QB | SR |
| 29 | Matt Ryan, Boston College | Georgia Tech | 15-SEP-07 | 44 | 30 | 0 | 435 | 14.5 | 1 | 0 | QB | SR |
| 30 | Chase Holbrook, New Mexico St. | UTEP | 15-SEP-07 | 48 | 36 | 1 | 434 | 12.06 | 3 | 0 | QB | JR |
| 31 | Graham Harrell, Texas Tech | Baylor | 03-NOV-07 | 46 | 37 | 0 | 433 | 11.7 | 3 | 0 | QB | JR |
| 32 | Graham Harrell, Texas Tech | Colorado | 27-OCT-07 | 62 | 46 | 4 | 431 | 9.37 | 3 | 0 | QB | JR |
| 32 | Ben Mauk, Cincinnati | Syracuse | 24-NOV-07 | 42 | 29 | 0 | 431 | 14.86 | 4 | 0 | QB | SR |
| 34 | Andre Woodson, Kentucky | Tennessee | 24-NOV-07 | 62 | 39 | 2 | 430 | 11.03 | 6 | 0 | QB | SR |
| 34 | Zac Robinson, Oklahoma St. | Texas | 03-NOV-07 | 42 | 30 | 0 | 430 | 14.33 | 2 | 0 | QB | SO |
| 36 | Thaddeus Lewis, Duke | Navy | 22-SEP-07 | 36 | 23 | 1 | 428 | 18.61 | 4 | 2 | QB | SO |
| 37 | Paul Smith, Tulsa | UCF | 01-DEC-07 | 55 | 28 | 3 | 426 | 15.21 | 3 | 0 | QB | SR |
| 37 | Adam Tafralis, San Jose St. | Utah St. | 22-SEP-07 | 48 | 35 | 2 | 426 | 12.17 | 3 | 0 | QB | SR |
| 39 | Colt Brennan, Hawaii | New Mexico St. | 27-OCT-07 | 46 | 29 | 1 | 425 | 14.66 | 6 | 0 | QB | SR |
| 39 | Graham Harrell, Texas Tech | Iowa St. | 06-OCT-07 | 43 | 36 | 1 | 425 | 11.81 | 4 | 0 | QB | JR |
| 39 | Graham Harrell, Texas Tech | Texas A&M | 13-OCT-07 | 37 | 30 | 0 | 425 | 14.17 | 3 | 0 | QB | JR |
| 42 | Nathan Enderle, Idaho | Northern Ill. | 22-SEP-07 | 54 | 27 | 3 | 423 | 15.67 | 2 | 0 | QB | SO |
| 42 | Andrew Robinson, Syracuse | Louisville | 22-SEP-07 | 26 | 17 | 0 | 423 | 24.88 | 4 | 0 | QB | SO |
| 44 | Nate Davis, Ball St. | Nebraska | 22-SEP-07 | 43 | 26 | 1 | 422 | 16.23 | 3 | 0 | QB | SO |
| 45 | Matt Ryan, Boston College | Maryland | 10-NOV-07 | 56 | 33 | 2 | 421 | 12.76 | 3 | 0 | QB | SR |
| 45 | Wesley Carroll, Mississippi St. | Arkansas | 17-NOV-07 | 51 | 29 | 4 | 421 | 14.52 | 4 | 0 | QB | FR |
| 45 | Chase Daniel, Missouri | Colorado | 03-NOV-07 | 44 | 26 | 1 | 421 | 16.19 | 5 | 0 | QB | JR |
| 48 | Graham Harrell, Texas Tech | Oklahoma | 17-NOV-07 | 72 | 47 | 2 | 420 | 8.94 | 2 | 0 | QB | JR |
| 49 | Graham Harrell, Texas Tech | Southern Methodist | 03-SEP-07 | 59 | 44 | 0 | 419 | 9.52 | 4 | 0 | QB | JR |
| 49 | Andrew Robinson, Syracuse | Cincinnati | 24-NOV-07 | 47 | 29 | 0 | 419 | 14.45 | 3 | 0 | QB | SO |
| 51 | Bernard Morris, Marshall | New Hampshire | 15-SEP-07 | 42 | 31 | 0 | 417 | 13.45 | 3 | 0 | QB | SR |
| 52 | Martin Hankins, Memphis | East Caro. | 03-NOV-07 | 60 | 34 | 2 | 416 | 12.24 | 4 | 1 | QB | SR |
| 52 | Colt Brennan, Hawaii | Northern Colo. | 01-SEP-07 | 40 | 34 | 0 | 416 | 12.24 | 6 | 0 | QB | SR |
| 54 | Matt Ryan, Boston College | Florida St. | 03-NOV-07 | 53 | 26 | 3 | 415 | 15.96 | 2 | 0 | QB | SR |
| 54 | Andre Woodson, Kentucky | Florida | 20-OCT-07 | 50 | 35 | 0 | 415 | 11.86 | 5 | 0 | QB | SR |
| 56 | Graham Harrell, Texas Tech | Rice | 15-SEP-07 | 37 | 28 | 1 | 414 | 14.79 | 6 | 0 | QB | JR |
| 57 | Blake Szymanski, Baylor | Rice | 08-SEP-07 | 46 | 29 | 0 | 412 | 14.21 | 6 | 0 | QB | JR |
| 58 | Blake Szymanski, Baylor | Texas St. | 15-SEP-07 | 51 | 31 | 2 | 411 | 13.26 | 5 | 0 | QB | JR |
| 59 | Blake Szymanski, Baylor | Colorado | 06-OCT-07 | 60 | 36 | 2 | 410 | 11.39 | 1 | 0 | QB | JR |
| 60 | Trevor Vittatoe, UTEP | East Caro. | 13-OCT-07 | 55 | 38 | 1 | 409 | 10.76 | 3 | 0 | QB | FR |
| 61 | Matt Ryan, Boston College | Wake Forest | 01-SEP-07 | 52 | 32 | 2 | 408 | 12.75 | 5 | 0 | QB | SR |
| 62 | Graham Harrell, Texas Tech | Virginia | 01-JAN-08 | 69 | 44 | 0 | 407 | 9.25 | 3 | 0 | QB | JR |
| 62 | Chase Holbrook, New Mexico St. | Nevada | 02-NOV-07 | 49 | 35 | 0 | 407 | 11.63 | 4 | 0 | QB | JR |
| 64 | Patrick Pinkney, East Caro. | North Carolina | 08-SEP-07 | 41 | 31 | 0 | 406 | 13.1 | 3 | 0 | QB | JR |
| 65 | Joe Ganz, Nebraska | Kansas | 03-NOV-07 | 50 | 25 | 4 | 405 | 16.2 | 4 | 1 | QB | JR |
| 66 | Josh Freeman, Kansas St. | Oklahoma St. | 20-OCT-07 | 51 | 36 | 0 | 404 | 11.22 | 3 | 1 | QB | SO |
| 66 | Chase Holbrook, New Mexico St. | Idaho | 20-OCT-07 | 49 | 36 | 0 | 404 | 11.22 | 3 | 0 | QB | JR |
| 66 | Colin Kaepernick, Nevada | Louisiana Tech | 01-DEC-07 | 29 | 18 | 0 | 404 | 22.44 | 3 | 0 | QB | FR |
| 69 | Chase Daniel, Missouri | Nebraska | 06-OCT-07 | 47 | 33 | 0 | 401 | 12.15 | 2 | 0 | QB | JR |
| 69 | Brian Brohm, Louisville | Middle Tenn. St. | 06-SEP-07 | 39 | 25 | 0 | 401 | 16.04 | 5 | 0 | QB | SR |
| 69 | Joe Craddock, Middle Tenn. St. | La.-Monroe | 03-NOV-07 | 29 | 22 | 0 | 401 | 18.23 | 4 | 0 | QB | JR |
| 72 | Alex Brink, Washington St. | Washington | 24-NOV-07 | 40 | 27 | 0 | 399 | 14.78 | 5 | 0 | QB | SR |
| 73 | Graham Harrell, Texas Tech | Missouri | 20-OCT-07 | 69 | 44 | 4 | 397 | 9.02 | 1 | 0 | QB | JR |
| 73 | Erik Ainge, Tennessee | Kentucky | 24-NOV-07 | 45 | 28 | 3 | 397 | 14.18 | 7 | 1 | QB | SR |
| 75 | Martin Hankins, Memphis | Southern Miss. | 10-NOV-07 | 48 | 35 | 2 | 396 | 11.31 | 4 | 1 | QB | SR |
| 75 | Colt Brennan, Hawaii | Fresno St. | 10-NOV-07 | 39 | 28 | 1 | 396 | 14.14 | 2 | 0 | QB | SR |
| 77 | Chase Clement, Rice | UTEP | 03-NOV-07 | 58 | 32 | 3 | 395 | 12.34 | 6 | 0 | QB | JR |
| 78 | Tyler Donovan, Wisconsin | Illinois | 06-OCT-07 | 49 | 27 | 2 | 392 | 14.52 | 2 | 0 | QB | SR |
| 79 | Max Hall, BYU | UCLA | 08-SEP-07 | 52 | 30 | 1 | 391 | 13.03 | 2 | 0 | QB | SO |
| 80 | Paul Smith, Tulsa | Army | 17-NOV-07 | 32 | 22 | 0 | 390 | 17.73 | 2 | 0 | QB | SR |
| 81 | Sam Keller, Nebraska | Southern California | 15-SEP-07 | 54 | 36 | 2 | 389 | 10.81 | 2 | 1 | QB | SR |
| 81 | Chris Jacquemain, Akron | Western Mich. | 06-OCT-07 | 41 | 23 | 1 | 389 | 16.91 | 4 | 0 | QB | SO |
| 83 | Tyler Sheehan, Bowling Green | Minnesota | 01-SEP-07 | 51 | 34 | 0 | 388 | 11.41 | 2 | 1 | QB | SO |
| 84 | Aaron Opelt, Toledo | Northern Ill. | 27-OCT-07 | 28 | 22 | 0 | 387 | 17.59 | 4 | 0 | QB | SO |
| 85 | Paul Smith, Tulsa | Marshall | 13-OCT-07 | 39 | 24 | 0 | 385 | 16.04 | 3 | 0 | QB | SR |
| 86 | Kevin O'Connell, San Diego St. | Air Force | 17-NOV-07 | 43 | 27 | 1 | 384 | 14.22 | 1 | 0 | QB | SR |
| 86 | Colin Kaepernick, Nevada | Fresno St. | 06-OCT-07 | 36 | 23 | 0 | 384 | 16.7 | 4 | 0 | QB | FR |
| 88 | Giovanni Vizza, North Texas | La.-Lafayette | 06-OCT-07 | 57 | 35 | 3 | 383 | 10.94 | 3 | 0 | QB | FR |
| 88 | Paul Smith, Tulsa | UTEP | 06-OCT-07 | 43 | 26 | 2 | 383 | 14.73 | 2 | 0 | QB | SR |
| 90 | Dan LeFevour, Central Mich. | Akron | 23-NOV-07 | 54 | 33 | 2 | 382 | 11.58 | 2 | 0 | QB | SO |
| 90 | Matt Grothe, South Fla. | Cincinnati | 03-NOV-07 | 54 | 31 | 4 | 382 | 12.32 | 1 | 0 | QB | SO |
| 92 | Rudy Carpenter, Arizona St. | Oregon | 03-NOV-07 | 36 | 22 | 1 | 379 | 17.23 | 2 | 0 | QB | JR |
| 93 | Justin Willis, Southern Methodist | Memphis | 24-NOV-07 | 48 | 35 | 2 | 375 | 10.71 | 4 | 0 | QB | SO |
| 93 | Tim Hiller, Western Mich. | Akron | 06-OCT-07 | 40 | 27 | 0 | 375 | 13.89 | 3 | 0 | QB | SO |
| 93 | John David Booty, Southern California | Arizona St. | 22-NOV-07 | 39 | 26 | 0 | 375 | 14.42 | 4 | 0 | QB | SR |
| 93 | Brian Brohm, Louisville | Murray St. | 30-AUG-07 | 21 | 16 | 0 | 375 | 23.44 | 4 | 0 | QB | SR |
| 97 | Dennis Dixon, Oregon | Stanford | 22-SEP-07 | 37 | 28 | 0 | 374 | 13.36 | 4 | 0 | QB | SR |
| 98 | Trevor Vittatoe, UTEP | Rice | 03-NOV-07 | 57 | 30 | 0 | 373 | 12.43 | 5 | 0 | QB | FR |
| 98 | Chad Henne, Michigan | Florida | 01-JAN-08 | 39 | 25 | 2 | 373 | 14.92 | 3 | 0 | QB | SR |
| 100 | Cullen Harper, Clemson | Virginia Tech | 06-OCT-07 | 66 | 38 | 2 | 372 | 9.79 | 2 | 1 | QB | JR |