| Rank | Player | Opponent | Sched Date | Carries | Gain | Loss | Net | TD | Average | Position | Class |
| 1 | Kevin Smith, UCF | UTEP | 24-NOV-07 | 46 | 223 | 4 | 219 | 1 | 4.76 | RB | JR |
| 2 | Matt Forte, Tulane | Memphis | 27-OCT-07 | 44 | 282 | 4 | 278 | 2 | 6.32 | RB | SR |
| 2 | Michael Hart, Michigan | Penn St. | 22-SEP-07 | 44 | 175 | 22 | 153 | 1 | 3.48 | RB | SR |
| 4 | Kevin Smith, UCF | Southern Miss. | 28-OCT-07 | 43 | 186 | 11 | 175 | 2 | 4.07 | RB | JR |
| 5 | Kalvin McRae, Ohio | Bowling Green | 27-OCT-07 | 42 | 207 | 7 | 200 | 3 | 4.76 | RB | SR |
| 6 | Kevin Smith, UCF | UAB | 10-NOV-07 | 41 | 332 | 12 | 320 | 4 | 7.8 | RB | JR |
| 6 | Rodney Ferguson, New Mexico | Air Force | 25-OCT-07 | 41 | 153 | 7 | 146 | 2 | 3.56 | RB | JR |
| 8 | Matt Forte, Tulane | Southeastern La. | 22-SEP-07 | 40 | 314 | 11 | 303 | 5 | 7.58 | RB | SR |
| 8 | Kyle Bell, Colorado St. | Colorado | 01-SEP-07 | 40 | 147 | 12 | 135 | 1 | 3.38 | RB | JR |
| 10 | Kevin Smith, UCF | Tulsa | 01-DEC-07 | 39 | 288 | 4 | 284 | 4 | 7.28 | RB | JR |
| 10 | Chris Wells, Ohio St. | Michigan | 17-NOV-07 | 39 | 230 | 8 | 222 | 2 | 5.69 | RB | SO |
| 10 | Matt Forte, Tulane | Rice | 17-NOV-07 | 39 | 197 | 3 | 194 | 5 | 4.97 | RB | SR |
| 10 | Ray Rice, Rutgers | South Fla. | 18-OCT-07 | 39 | 189 | 8 | 181 | 0 | 4.64 | RB | JR |
| 10 | Jonathan Stewart, Oregon | Oregon St. | 01-DEC-07 | 39 | 177 | 14 | 163 | 0 | 4.18 | RB | JR |
| 10 | Justin Anderson, Northern Ill. | Navy | 17-NOV-07 | 39 | 143 | 3 | 140 | 1 | 3.59 | RB | SO |
| 16 | Matt Forte, Tulane | Southern Methodist | 20-OCT-07 | 38 | 349 | 7 | 342 | 4 | 9 | RB | SR |
| 16 | Jalen Parmele, Toledo | Ohio | 20-OCT-07 | 38 | 247 | 6 | 241 | 2 | 6.34 | RB | SR |
| 16 | Yvenson Bernard, Oregon St. | Maryland | 28-DEC-07 | 38 | 181 | 4 | 177 | 1 | 4.66 | RB | SR |
| 16 | Matt Forte, Tulane | UTEP | 10-NOV-07 | 38 | 178 | 7 | 171 | 2 | 4.5 | RB | SR |
| 16 | LeSean McCoy, Pittsburgh | West Virginia | 01-DEC-07 | 38 | 153 | 5 | 148 | 0 | 3.89 | RB | FR |
| 21 | Dwight Tardy, Washington St. | UCLA | 27-OCT-07 | 37 | 224 | 10 | 214 | 2 | 5.78 | RB | JR |
| 21 | Tashard Choice, Georgia Tech | Miami (Fla.) | 13-OCT-07 | 37 | 206 | 2 | 204 | 0 | 5.51 | RB | SR |
| 21 | Ray Rice, Rutgers | Navy | 07-SEP-07 | 37 | 181 | 6 | 175 | 2 | 4.73 | RB | JR |
| 24 | Louis Rankin, Washington | Stanford | 03-NOV-07 | 36 | 273 | 18 | 255 | 1 | 7.08 | RB | SR |
| 24 | Luke Lippincott, Nevada | Utah St. | 20-OCT-07 | 36 | 244 | 3 | 241 | 2 | 6.69 | RB | JR |
| 24 | Ray Rice, Rutgers | Syracuse | 13-OCT-07 | 36 | 199 | 3 | 196 | 3 | 5.44 | RB | JR |
| 24 | James Starks, Buffalo | Ohio | 06-OCT-07 | 36 | 202 | 19 | 183 | 2 | 5.08 | RB | SO |
| 24 | Yvenson Bernard, Oregon St. | Washington | 10-NOV-07 | 36 | 154 | 5 | 149 | 0 | 4.14 | RB | SR |
| 29 | Ray Rice, Rutgers | Ball St. | 05-JAN-08 | 35 | 282 | 2 | 280 | 4 | 8 | RB | JR |
| 29 | Anthony Allen, Louisville | Middle Tenn. St. | 06-SEP-07 | 35 | 278 | 3 | 275 | 2 | 7.86 | RB | SO |
| 29 | Kevin Smith, UCF | North Carolina St. | 01-SEP-07 | 35 | 219 | 2 | 217 | 2 | 6.2 | RB | JR |
| 29 | Marcus Thomas, UTEP | Southern Methodist | 29-SEP-07 | 35 | 212 | 5 | 207 | 3 | 5.91 | RB | SR |
| 29 | Michael Hart, Michigan | Notre Dame | 15-SEP-07 | 35 | 190 | 3 | 187 | 2 | 5.34 | RB | SR |
| 29 | Justin Anderson, Northern Ill. | Idaho | 22-SEP-07 | 35 | 173 | 6 | 167 | 1 | 4.77 | RB | SO |
| 29 | Stephen McGee, Texas A&M | Nebraska | 20-OCT-07 | 35 | 184 | 17 | 167 | 0 | 4.77 | QB | JR |
| 29 | Kevin Smith, UCF | Mississippi St. | 29-DEC-07 | 35 | 129 | 10 | 119 | 0 | 3.4 | RB | JR |
| 37 | Darren McFadden, Arkansas | South Carolina | 03-NOV-07 | 34 | 326 | 5 | 321 | 1 | 9.44 | RB | JR |
| 37 | Chad Hall, Air Force | Army | 03-NOV-07 | 34 | 281 | 6 | 275 | 1 | 8.09 | WR | SR |
| 37 | Ray Rice, Rutgers | Army | 09-NOV-07 | 34 | 244 | 1 | 243 | 2 | 7.15 | RB | JR |
| 37 | James Starks, Buffalo | Toledo | 13-OCT-07 | 34 | 233 | 2 | 231 | 3 | 6.79 | RB | SO |
| 37 | Damion Fletcher, Southern Miss. | UTEP | 17-NOV-07 | 34 | 211 | 0 | 211 | 3 | 6.21 | RB | SO |
| 37 | Eugene Jarvis, Kent St. | Buffalo | 24-NOV-07 | 34 | 196 | 13 | 183 | 0 | 5.38 | RB | SO |
| 37 | Albert Young, Iowa | Michigan St. | 27-OCT-07 | 34 | 182 | 3 | 179 | 2 | 5.26 | RB | SR |
| 37 | P.J. Hill, Wisconsin | Michigan St. | 29-SEP-07 | 34 | 162 | 7 | 155 | 2 | 4.56 | RB | SO |
| 37 | J.J. Bass, Iowa St. | Toledo | 22-SEP-07 | 34 | 143 | 9 | 134 | 2 | 3.94 | RB | JR |
| 37 | Keon Lattimore, Maryland | Rutgers | 29-SEP-07 | 34 | 134 | 10 | 124 | 1 | 3.65 | RB | SR |
| 37 | Ray Rice, Rutgers | Cincinnati | 06-OCT-07 | 34 | 106 | 12 | 94 | 1 | 2.76 | RB | JR |
| 48 | Jamaal Charles, Texas | Nebraska | 27-OCT-07 | 33 | 296 | 6 | 290 | 3 | 8.79 | RB | JR |
| 48 | BenJarvus Green-Ellis, Mississippi | Missouri | 08-SEP-07 | 33 | 228 | 2 | 226 | 1 | 6.85 | RB | SR |
| 48 | Joseph Turner, TCU | San Diego St. | 24-NOV-07 | 33 | 226 | 0 | 226 | 4 | 6.85 | RB | SO |
| 48 | Kevin Smith, UCF | La.-Lafayette | 29-SEP-07 | 33 | 223 | 0 | 223 | 3 | 6.76 | RB | JR |
| 48 | Darren McFadden, Arkansas | Alabama | 15-SEP-07 | 33 | 195 | 0 | 195 | 2 | 5.91 | RB | JR |
| 48 | Knowshon Moreno, Georgia | Florida | 27-OCT-07 | 33 | 193 | 5 | 188 | 3 | 5.7 | RB | FR |
| 48 | Kevin Smith, UCF | Tulsa | 20-OCT-07 | 33 | 180 | 10 | 170 | 3 | 5.15 | RB | JR |
| 48 | Hugh Charles, Colorado | Nebraska | 23-NOV-07 | 33 | 175 | 6 | 169 | 3 | 5.12 | RB | SR |
| 48 | Eugene Jarvis, Kent St. | Bowling Green | 20-OCT-07 | 33 | 171 | 3 | 168 | 0 | 5.09 | RB | SO |
| 48 | Pierre Walker, Eastern Mich. | Western Mich. | 27-OCT-07 | 33 | 160 | 9 | 151 | 0 | 4.58 | RB | SR |
| 48 | Tashard Choice, Georgia Tech | North Carolina | 17-NOV-07 | 33 | 146 | 4 | 142 | 0 | 4.3 | RB | SR |
| 48 | Tyrell Sutton, Northwestern | Indiana | 10-NOV-07 | 33 | 144 | 3 | 141 | 1 | 4.27 | RB | JR |
| 48 | Rodney Ferguson, New Mexico | UTEP | 01-SEP-07 | 33 | 138 | 6 | 132 | 0 | 4 | RB | JR |
| 48 | Dan LeFevour, Central Mich. | Purdue | 26-DEC-07 | 33 | 144 | 30 | 114 | 2 | 3.45 | QB | SO |
| 48 | Yvenson Bernard, Oregon St. | California | 13-OCT-07 | 33 | 118 | 8 | 110 | 2 | 3.33 | RB | SR |
| 48 | Calvin Dawson, La.-Monroe | Alabama | 17-NOV-07 | 33 | 115 | 24 | 91 | 1 | 2.76 | RB | SR |
| 64 | Jonathan Stewart, Oregon | Washington | 20-OCT-07 | 32 | 257 | 6 | 251 | 2 | 7.84 | RB | JR |
| 64 | Matt Forte, Tulane | UAB | 13-OCT-07 | 32 | 212 | 3 | 209 | 1 | 6.53 | RB | SR |
| 64 | Darren McFadden, Arkansas | LSU | 23-NOV-07 | 32 | 211 | 5 | 206 | 3 | 6.44 | RB | JR |
| 64 | Matt Forte, Tulane | Army | 06-OCT-07 | 32 | 204 | 2 | 202 | 2 | 6.31 | RB | SR |
| 64 | Kalvin McRae, Ohio | Eastern Mich. | 13-OCT-07 | 32 | 187 | 17 | 170 | 2 | 5.31 | RB | SR |
| 64 | Andre Dixon, Connecticut | South Fla. | 27-OCT-07 | 32 | 168 | 1 | 167 | 0 | 5.22 | RB | SO |
| 64 | LeSean McCoy, Pittsburgh | Navy | 10-OCT-07 | 32 | 169 | 4 | 165 | 3 | 5.16 | RB | FR |
| 64 | Darrell Mack, Utah | Louisville | 05-OCT-07 | 32 | 165 | 2 | 163 | 3 | 5.09 | RB | JR |
| 64 | Jamelle Eugene, North Carolina St. | North Carolina | 10-NOV-07 | 32 | 159 | 0 | 159 | 3 | 4.97 | RB | SO |
| 64 | Anthony Dixon, Mississippi St. | UAB | 06-OCT-07 | 32 | 157 | 5 | 152 | 3 | 4.75 | RB | SO |
| 64 | Tashard Choice, Georgia Tech | Clemson | 29-SEP-07 | 32 | 153 | 8 | 145 | 1 | 4.53 | RB | SR |
| 64 | Chad Hall, Air Force | Notre Dame | 10-NOV-07 | 32 | 149 | 7 | 142 | 0 | 4.44 | WR | SR |
| 64 | Yvenson Bernard, Oregon St. | Arizona | 06-OCT-07 | 32 | 147 | 7 | 140 | 2 | 4.38 | RB | SR |
| 64 | Tashard Choice, Georgia Tech | Maryland | 06-OCT-07 | 32 | 137 | 2 | 135 | 1 | 4.22 | RB | SR |
| 64 | Michael Hart, Michigan | Florida | 01-JAN-08 | 32 | 136 | 7 | 129 | 2 | 4.03 | RB | SR |
| 64 | James Aldridge, Notre Dame | Navy | 03-NOV-07 | 32 | 130 | 5 | 125 | 0 | 3.91 | RB | SO |
| 64 | Andre Callender, Boston College | Massachusetts | 29-SEP-07 | 32 | 116 | 1 | 115 | 2 | 3.59 | RB | SR |
| 64 | Lance Ball, Maryland | Boston College | 10-NOV-07 | 32 | 122 | 13 | 109 | 1 | 3.41 | RB | SR |
| 64 | Darrell Mack, Utah | TCU | 18-OCT-07 | 32 | 101 | 1 | 100 | 1 | 3.13 | RB | JR |
| 83 | Chad Hall, Air Force | Colorado St. | 13-OCT-07 | 31 | 262 | 6 | 256 | 4 | 8.26 | WR | SR |
| 83 | Chris Wells, Ohio St. | Michigan St. | 20-OCT-07 | 31 | 234 | 13 | 221 | 1 | 7.13 | RB | SO |
| 83 | Luke Lippincott, Nevada | Boise St. | 14-OCT-07 | 31 | 187 | 0 | 187 | 4 | 6.03 | RB | JR |
| 83 | Gartrell Johnson III, Colorado St. | New Mexico | 10-NOV-07 | 31 | 183 | 11 | 172 | 0 | 5.55 | RB | JR |
| 83 | Justin Forsett, California | Southern California | 10-NOV-07 | 31 | 171 | 7 | 164 | 1 | 5.29 | RB | SR |
| 83 | Pierre Walker, Eastern Mich. | Bowling Green | 09-NOV-07 | 31 | 165 | 10 | 155 | 1 | 5 | RB | SR |
| 83 | Anthony Alridge, Houston | Southern Methodist | 04-NOV-07 | 31 | 165 | 11 | 154 | 2 | 4.97 | RB | SR |
| 83 | Jamad Williams, Tulsa | Tulane | 03-NOV-07 | 31 | 161 | 8 | 153 | 0 | 4.94 | RB | FR |
| 83 | Pierre Walker, Eastern Mich. | Central Mich. | 16-NOV-07 | 31 | 159 | 10 | 149 | 3 | 4.81 | RB | SR |
| 83 | Branden Ore, Virginia Tech | Virginia | 24-NOV-07 | 31 | 148 | 1 | 147 | 0 | 4.74 | RB | JR |
| 83 | LeSean McCoy, Pittsburgh | Syracuse | 03-NOV-07 | 31 | 143 | 3 | 140 | 1 | 4.52 | RB | FR |
| 83 | Justin Forsett, California | Washington St. | 03-NOV-07 | 31 | 148 | 19 | 129 | 2 | 4.16 | RB | SR |
| 83 | Jason Scales, Iowa St. | Nebraska | 29-SEP-07 | 31 | 127 | 12 | 115 | 2 | 3.71 | RB | JR |
| 83 | J.T. Callier, San Jose St. | Idaho | 06-OCT-07 | 31 | 99 | 6 | 93 | 2 | 3 | RB | SR |
| 97 | Marlon Lucky, Nebraska | Nevada | 01-SEP-07 | 30 | 235 | 2 | 233 | 3 | 7.77 | RB | JR |
| 97 | Eugene Jarvis, Kent St. | Ohio | 29-SEP-07 | 30 | 242 | 12 | 230 | 2 | 7.67 | RB | SO |
| 97 | Deonte Jackson, Idaho | Cal Poly | 08-SEP-07 | 30 | 216 | 2 | 214 | 1 | 7.13 | RB | FR |
| 97 | Cedric Peerman, Virginia | North Carolina | 15-SEP-07 | 30 | 191 | 5 | 186 | 1 | 6.2 | RB | JR |
| 97 | Nicholas Grigsby, Arizona | Washington St. | 29-SEP-07 | 30 | 186 | 0 | 186 | 0 | 6.2 | RB | FR |
| 97 | Jalen Parmele, Toledo | Liberty | 06-OCT-07 | 30 | 172 | 3 | 169 | 3 | 5.63 | RB | SR |
| 97 | Damion Fletcher, Southern Miss. | Marshall | 21-OCT-07 | 30 | 169 | 17 | 152 | 3 | 5.07 | RB | SO |
| 97 | P.J. Hill, Wisconsin | UNLV | 08-SEP-07 | 30 | 147 | 0 | 147 | 0 | 4.9 | RB | SO |
| 97 | Luke Lippincott, Nevada | New Mexico St. | 02-NOV-07 | 30 | 148 | 5 | 143 | 0 | 4.77 | RB | JR |
| 97 | Ray Rice, Rutgers | West Virginia | 27-OCT-07 | 30 | 143 | 1 | 142 | 0 | 4.73 | RB | JR |
| 97 | Glen Coffee, Alabama | Houston | 06-OCT-07 | 30 | 122 | 1 | 121 | 1 | 4.03 | RB | SO |
| 97 | Ray Rice, Rutgers | Louisville | 29-NOV-07 | 30 | 128 | 8 | 120 | 3 | 4 | RB | JR |
| 97 | Brandon West, Western Mich. | Iowa | 17-NOV-07 | 30 | 120 | 4 | 116 | 0 | 3.87 | RB | SO |
| 97 | Michael Hart, Michigan | Northwestern | 29-SEP-07 | 30 | 111 | 5 | 106 | 1 | 3.53 | RB | SR |
| 97 | Chris Markey, UCLA | Oregon | 24-NOV-07 | 30 | 99 | 8 | 91 | 0 | 3.03 | RB | SR |