| Rank | Player | Opponent | Sched Date | INT | YARDS | TD | Position | Class |
| 1 | Ryan Hamilton, Vanderbilt | Mississippi | 20-SEP-08 | 3 | 103 | 1 | DB | JR |
| 1 | Loyce Means, Houston | Tulsa | 15-NOV-08 | 3 | 95 | 1 | DB | SO |
| 1 | Michael Hamlin, Clemson | Citadel | 06-SEP-08 | 3 | 78 | 0 | DB | SR |
| 1 | Rashad Johnson, Alabama | LSU | 08-NOV-08 | 3 | 64 | 1 | DB | JR |
| 1 | Sherrod Martin, Troy | Alcorn St. | 13-SEP-08 | 3 | 40 | 0 | DB | SR |
| 1 | Brian Lainhart, Kent St. | Akron | 04-OCT-08 | 3 | 27 | 0 | DB | SO |
| 1 | Brandyn Thompson, Boise St. | Hawaii | 17-OCT-08 | 3 | 24 | 0 | DB | SO |
| 1 | Daniel Charbonnet, Texas Tech | SMU | 13-SEP-08 | 3 | 12 | 0 | DB | SR |
| 1 | Darcel McBath, Texas Tech | Kansas | 25-OCT-08 | 3 | 7 | 0 | DB | SR |
| 1 | Sean Baker, Ball St. | Akron | 13-SEP-08 | 3 | 0 | 0 | DB | FR |
| 11 | Deshawn Richard, Utah | San Diego St. | 15-NOV-08 | 2 | 127 | 2 | DB | SR |
| 11 | Syd'Quan Thompson, California | Washington St. | 06-SEP-08 | 2 | 108 | 0 | DB | JR |
| 11 | Tyrrell Herbert, Toledo | Michigan | 11-OCT-08 | 2 | 100 | 1 | DB | SR |
| 11 | Anthony Gaitor, Florida Int'l | Middle Tenn. St. | 11-OCT-08 | 2 | 98 | 1 | DB | SO |
| 11 | Darryl Gamble, Georgia | LSU | 25-OCT-08 | 2 | 93 | 2 | LB | SO |
| 11 | Otis Wiley, Michigan St. | California | 30-AUG-08 | 2 | 84 | 1 | DB | SR |
| 11 | Ahmad Black, Florida | Hawaii | 30-AUG-08 | 2 | 80 | 1 | DB | SO |
| 11 | Marcus Ezeff, California | UCLA | 25-OCT-08 | 2 | 78 | 1 | DB | JR |
| 11 | Sha'reff Rashad, UCF | Marshall | 15-NOV-08 | 2 | 77 | 0 | DB | SR |
| 11 | Paul Anderson, Boston College | Notre Dame | 08-NOV-08 | 2 | 76 | 1 | DB | SR |
| 11 | Tyler Sash, Iowa | South Carolina | 01-JAN-09 | 2 | 74 | 0 | DB | SO |
| 11 | Trevin Wade, Arizona | Idaho | 30-AUG-08 | 2 | 69 | 0 | DB | FR |
| 11 | Robert McClain III, Connecticut | Cincinnati | 25-OCT-08 | 2 | 68 | 1 | CB | JR |
| 11 | Glover Quin, New Mexico | Tulsa | 20-SEP-08 | 2 | 65 | 0 | DB | SR |
| 11 | Greg Williams, Pittsburgh | Connecticut | 06-DEC-08 | 2 | 61 | 1 | LB | FR |
| 11 | Mark Herzlich, Boston College | Wake Forest | 22-NOV-08 | 2 | 60 | 1 | LB | JR |
| 11 | Traye Simmons, Minnesota | Northwestern | 01-NOV-08 | 2 | 58 | 1 | DB | JR |
| 11 | Brandon King, Rice | SMU | 29-AUG-08 | 2 | 56 | 0 | DB | SR |
| 11 | Sean Smith, Utah | Wyoming | 11-OCT-08 | 2 | 56 | 1 | DB | JR |
| 11 | Brandon Spikes, Florida | LSU | 11-OCT-08 | 2 | 55 | 1 | LB | JR |
| 11 | Greg James, La.-Monroe | La.-Lafayette | 04-OCT-08 | 2 | 55 | 1 | DB | JR |
| 11 | Travis Lewis, Oklahoma | Kansas St. | 25-OCT-08 | 2 | 55 | 0 | LB | FR |
| 11 | Lydell Sargeant, Penn St. | Wisconsin | 11-OCT-08 | 2 | 55 | 0 | DB | SR |
| 11 | Kevin Patterson, Wake Forest | Florida St. | 20-SEP-08 | 2 | 54 | 0 | DB | SR |
| 11 | Brandon Hogan, West Virginia | Connecticut | 01-NOV-08 | 2 | 50 | 0 | WR | SO |
| 11 | Roy Roberts, Tulsa | New Mexico | 20-SEP-08 | 2 | 49 | 1 | DB | SR |
| 11 | David Skehan, Tulane | Tulsa | 22-NOV-08 | 2 | 48 | 0 | DB | SR |
| 11 | Frank Scappaticci, Army | Tulane | 04-OCT-08 | 2 | 47 | 1 | LB | SR |
| 11 | Raeshon McNeil, Notre Dame | Pittsburgh | 01-NOV-08 | 2 | 47 | 0 | DB | JR |
| 11 | Morgan Burnett, Georgia Tech | Jacksonville St. | 28-AUG-08 | 2 | 47 | 0 | DB | SO |
| 11 | Duke Ihenacho, San Jose St. | Utah St. | 11-OCT-08 | 2 | 44 | 1 | DB | SO |
| 11 | Michael Mitchell, Ohio | Northwestern | 20-SEP-08 | 2 | 43 | 0 | DB | SR |
| 11 | Chris Culliver, South Carolina | Kentucky | 11-OCT-08 | 2 | 43 | 0 | DB | SO |
| 11 | Van Eskridge, East Carolina | Tulsa | 06-DEC-08 | 2 | 40 | 0 | DB | JR |
| 11 | Kendric Burney, North Carolina | Boston College | 25-OCT-08 | 2 | 37 | 0 | DB | SO |
| 11 | Trimane Goddard, North Carolina | Miami (Fla.) | 27-SEP-08 | 2 | 35 | 0 | DB | SR |
| 11 | Eric Fraser, Central Mich. | Temple | 11-OCT-08 | 2 | 35 | 0 | DB | JR |
| 11 | Sean Weatherspoon, Missouri | Illinois | 30-AUG-08 | 2 | 35 | 1 | LB | JR |
| 11 | Kevin Sanders, UAB | Tulane | 15-NOV-08 | 2 | 34 | 0 | DB | SR |
| 11 | Emanuel Davis, East Carolina | Marshall | 08-NOV-08 | 2 | 31 | 0 | DB | FR |
| 11 | Phillip Strozier, Kansas | Florida Int'l | 30-AUG-08 | 2 | 30 | 0 | DB | SO |
| 11 | Jason McCourty, Rutgers | South Fla. | 15-NOV-08 | 2 | 30 | 1 | DB | SR |
| 11 | Nick Sanders, TCU | BYU | 16-OCT-08 | 2 | 29 | 0 | DB | JR |
| 11 | Archie Donald, Toledo | Eastern Mich. | 13-SEP-08 | 2 | 28 | 0 | LB | JR |
| 11 | Stephan Virgil, Virginia Tech | Duke | 22-NOV-08 | 2 | 26 | 0 | DB | JR |
| 11 | Isaac Butts, Idaho | Idaho St. | 06-SEP-08 | 2 | 25 | 0 | DB | SO |
| 11 | Walter Thurmond III, Oregon | Washington St. | 27-SEP-08 | 2 | 25 | 0 | DB | JR |
| 11 | Victor Harris, Virginia Tech | Duke | 22-NOV-08 | 2 | 23 | 1 | DB | SR |
| 11 | Charles Davis, Tulsa | New Mexico | 20-SEP-08 | 2 | 21 | 0 | DB | JR |
| 11 | John Syty, Buffalo | UTEP | 28-AUG-08 | 2 | 21 | 0 | LB | FR |
| 11 | Cornelius Brown, UTEP | UCF | 27-SEP-08 | 2 | 21 | 0 | DB | JR |
| 11 | Pat Angerer, Iowa | Wisconsin | 18-OCT-08 | 2 | 19 | 0 | LB | JR |
| 11 | Darrell Stuckey, Kansas | Missouri | 29-NOV-08 | 2 | 19 | 0 | DB | JR |
| 11 | Niles Brinkley, Wisconsin | Marshall | 06-SEP-08 | 2 | 17 | 0 | DB | SO |
| 11 | Brandon Carlisle, UAB | South Carolina | 27-SEP-08 | 2 | 16 | 0 | DB | JR |
| 11 | Adrian Aye-Darko, Duke | Miami (Fla.) | 18-OCT-08 | 2 | 14 | 0 | DB | SR |
| 11 | Keao Monteilh, Hawaii | Fresno St. | 04-OCT-08 | 2 | 13 | 0 | DB | SR |
| 11 | Russell Brorsen, Kansas | Kansas St. | 01-NOV-08 | 2 | 13 | 0 | DL | SR |
| 11 | Darian Hagan, California | Washington | 06-DEC-08 | 2 | 12 | 0 | DB | SO |
| 11 | Austin Thomas, Indiana | Northwestern | 25-OCT-08 | 2 | 11 | 0 | DB | JR |
| 11 | Lendy Holmes, Oklahoma | Kansas | 18-OCT-08 | 2 | 11 | 0 | DB | SR |
| 11 | Keith Fitzhugh, Mississippi St. | Louisiana Tech | 30-AUG-08 | 2 | 11 | 0 | DB | SR |
| 11 | Jamari McCollough, Maryland | Eastern Mich. | 20-SEP-08 | 2 | 10 | 0 | DB | JR |
| 11 | Terence Moore, Troy | Alcorn St. | 13-SEP-08 | 2 | 10 | 0 | DB | SR |
| 11 | Joe Dale, Utah | BYU | 22-NOV-08 | 2 | 9 | 0 | DB | JR |
| 11 | Chris Prosinski, Wyoming | North Dakota St. | 13-SEP-08 | 2 | 8 | 0 | DB | SO |
| 11 | Robert Johnson, Utah | Alabama | 02-JAN-09 | 2 | 7 | 0 | DB | JR |
| 11 | Sha'reff Rashad, UCF | Miami (Fla.) | 11-OCT-08 | 2 | 6 | 0 | DB | SR |
| 11 | Kyle Wilson, Boise St. | Oregon | 20-SEP-08 | 2 | 4 | 0 | DB | JR |
| 11 | Justin Wilson, Southern Miss. | East Carolina | 15-NOV-08 | 2 | 3 | 0 | DB | SO |
| 11 | Marvin Haynes, Fresno St. | Rutgers | 01-SEP-08 | 2 | 2 | 0 | DB | JR |
| 11 | Joe Pawelek, Baylor | Texas A&M | 15-NOV-08 | 2 | 1 | 0 | LB | JR |
| 11 | Kurt Coleman, Ohio St. | Troy | 20-SEP-08 | 2 | 0 | 0 | DB | JR |
| 11 | George Iloka, Boise St. | Utah St. | 08-NOV-08 | 2 | 0 | 0 | DB | FR |
| 11 | Otis Wiley, Michigan St. | Notre Dame | 20-SEP-08 | 2 | 0 | 0 | DB | SR |
| 11 | Morgan Trent, Michigan | Notre Dame | 13-SEP-08 | 2 | 0 | 0 | DB | SR |
| 11 | Earl Thomas, Texas | Oklahoma | 11-OCT-08 | 2 | 0 | 0 | DB | FR |
| 11 | Alphonso Smith, Wake Forest | Duke | 01-NOV-08 | 2 | 0 | 0 | DB | SR |
| 11 | D.J. Moore, Vanderbilt | Kentucky | 15-NOV-08 | 2 | 0 | 0 | DB | JR |
| 11 | Morgan Burnett, Georgia Tech | Clemson | 18-OCT-08 | 2 | 0 | 0 | DB | SO |
| 11 | Tony Carter, Florida St. | Miami (Fla.) | 04-OCT-08 | 2 | 0 | 0 | DB | SR |
| 11 | Trent Hunter, Texas A&M | Colorado | 01-NOV-08 | 2 | 0 | 0 | DB | FR |
| 11 | Ketric Buffin, Navy | Notre Dame | 15-NOV-08 | 2 | 0 | 0 | DB | SR |
| 11 | Bryan McCann, SMU | Tulsa | 11-OCT-08 | 2 | 0 | 0 | DB | JR |
| 11 | Chris Chancellor, Clemson | South Carolina | 29-NOV-08 | 2 | 0 | 0 | DB | JR |
| 11 | Carlton Williams, South Fla. | Rutgers | 15-NOV-08 | 2 | 0 | 0 | DB | SR |
| 11 | Ras-I Dowling, Virginia | Duke | 27-SEP-08 | 2 | 0 | 0 | DB | SO |
| 11 | Xavier Hicks, Jr., Washington St. | Oregon St. | 11-OCT-08 | 2 | 0 | 0 | DB | JR |
| 11 | Woodny Turenne, Louisville | Kansas St. | 17-SEP-08 | 2 | -2 | 0 | CB | SR |
| 11 | Jermaine Jenkins, Eastern Mich. | Indiana St. | 28-AUG-08 | 2 | -9 | 0 | DB | SR |
| 11 | Chris Hawkins, LSU | Auburn | 20-SEP-08 | 2 | -9 | 0 | DB | JR |