| Rank | Player | Opponent | Sched Date | ATT | COMP | INT | NET | Average | TD | CM | Position | Class |
| 1 | Andy Schmitt, Eastern Mich. | Central Mich. | 28-NOV-08 | 80 | 58 | 1 | 516 | 8.9 | 5 | 0 | QB | JR |
| 2 | Andy Schmitt, Eastern Mich. | Temple | 22-NOV-08 | 76 | 50 | 0 | 484 | 9.68 | 3 | 0 | QB | JR |
| 3 | Chase Holbrook, New Mexico St. | Louisiana Tech | 22-NOV-08 | 59 | 45 | 0 | 486 | 10.8 | 4 | 0 | QB | SR |
| 4 | Graham Harrell, Texas Tech | Texas A&M | 18-OCT-08 | 56 | 44 | 2 | 450 | 10.23 | 3 | 0 | QB | SR |
| 5 | Graham Harrell, Texas Tech | Eastern Wash. | 30-AUG-08 | 58 | 43 | 1 | 536 | 12.47 | 2 | 1 | QB | SR |
| 6 | Tim Hiller, Western Mich. | Buffalo | 11-OCT-08 | 63 | 42 | 1 | 345 | 8.21 | 4 | 1 | QB | JR |
| 7 | Colt McCoy, Texas | Ohio St. | 05-JAN-09 | 58 | 41 | 1 | 414 | 10.1 | 2 | 0 | QB | JR |
| 7 | Case Keenum, Houston | UTEP | 22-NOV-08 | 51 | 41 | 0 | 480 | 11.71 | 3 | 0 | QB | SO |
| 7 | Graham Harrell, Texas Tech | Baylor | 29-NOV-08 | 50 | 41 | 1 | 309 | 7.54 | 2 | 0 | QB | SR |
| 10 | Graham Harrell, Texas Tech | Oklahoma St. | 08-NOV-08 | 50 | 40 | 0 | 456 | 11.4 | 6 | 0 | QB | SR |
| 10 | Levi Brown, Troy | North Texas | 25-OCT-08 | 50 | 40 | 0 | 391 | 9.78 | 2 | 0 | QB | JR |
| 12 | Chase Daniel, Missouri | Oklahoma St. | 11-OCT-08 | 52 | 39 | 3 | 390 | 10 | 1 | 0 | QB | SR |
| 13 | Case Keenum, Houston | Colorado St. | 20-SEP-08 | 55 | 38 | 3 | 385 | 10.13 | 3 | 1 | QB | SO |
| 13 | Curtis Painter, Purdue | Indiana | 22-NOV-08 | 54 | 38 | 0 | 448 | 11.79 | 5 | 0 | QB | SR |
| 13 | Tim Hiller, Western Mich. | Central Mich. | 18-OCT-08 | 53 | 38 | 0 | 471 | 12.39 | 2 | 0 | QB | JR |
| 13 | Graham Harrell, Texas Tech | Kansas St. | 04-OCT-08 | 51 | 38 | 0 | 454 | 11.95 | 6 | 0 | QB | SR |
| 13 | Colt McCoy, Texas | Oklahoma St. | 25-OCT-08 | 45 | 38 | 1 | 391 | 10.29 | 2 | 0 | QB | JR |
| 18 | Giovanni Vizza, North Texas | La.-Monroe | 18-OCT-08 | 61 | 37 | 0 | 362 | 9.78 | 2 | 0 | QB | SO |
| 18 | Todd Reesing, Kansas | Florida Int'l | 30-AUG-08 | 52 | 37 | 1 | 256 | 6.92 | 3 | 0 | QB | JR |
| 18 | Thaddeus Lewis, Duke | North Carolina St. | 08-NOV-08 | 52 | 37 | 0 | 317 | 8.57 | 2 | 0 | QB | JR |
| 18 | Todd Reesing, Kansas | Missouri | 29-NOV-08 | 51 | 37 | 2 | 375 | 10.14 | 4 | 0 | QB | JR |
| 18 | Chase Holbrook, New Mexico St. | Idaho | 25-OCT-08 | 47 | 37 | 2 | 324 | 8.76 | 2 | 0 | QB | SR |
| 18 | Case Keenum, Houston | East Carolina | 27-SEP-08 | 45 | 37 | 1 | 401 | 10.84 | 3 | 0 | QB | SO |
| 24 | Graham Harrell, Texas Tech | Mississippi | 02-JAN-09 | 58 | 36 | 2 | 364 | 10.11 | 4 | 0 | QB | SR |
| 24 | Austen Arnaud, Iowa St. | Missouri | 15-NOV-08 | 54 | 36 | 2 | 326 | 9.06 | 2 | 0 | QB | SO |
| 24 | Sam Bradford, Oklahoma | Kansas | 18-OCT-08 | 53 | 36 | 0 | 468 | 13 | 3 | 0 | QB | SO |
| 24 | Graham Harrell, Texas Tech | Texas | 01-NOV-08 | 53 | 36 | 0 | 474 | 13.17 | 2 | 0 | QB | SR |
| 24 | Joe Ganz, Nebraska | Texas Tech | 11-OCT-08 | 44 | 36 | 1 | 349 | 9.69 | 2 | 0 | QB | SR |
| 24 | Chase Daniel, Missouri | Buffalo | 20-SEP-08 | 43 | 36 | 0 | 439 | 12.19 | 2 | 0 | QB | SR |
| 30 | Case Keenum, Houston | Oklahoma St. | 06-SEP-08 | 61 | 35 | 0 | 387 | 11.06 | 4 | 0 | QB | SO |
| 30 | Brian Brunner, Central Mich. | Indiana | 01-NOV-08 | 53 | 35 | 1 | 485 | 13.86 | 4 | 0 | QB | SR |
| 30 | Ryan Lindley, San Diego St. | UNLV | 22-NOV-08 | 50 | 35 | 0 | 387 | 11.06 | 2 | 0 | QB | FR |
| 33 | Levi Brown, Troy | LSU | 15-NOV-08 | 72 | 34 | 1 | 316 | 9.29 | 2 | 0 | QB | JR |
| 33 | C.J. Bacher, Northwestern | Michigan St. | 11-OCT-08 | 61 | 34 | 2 | 283 | 8.32 | 1 | 0 | QB | SR |
| 33 | Case Keenum, Houston | Air Force | 13-SEP-08 | 57 | 34 | 1 | 362 | 10.65 | 4 | 0 | QB | SO |
| 33 | Lyle Moevao, Oregon St. | Stanford | 28-AUG-08 | 54 | 34 | 2 | 404 | 11.88 | 3 | 1 | QB | JR |
| 33 | Todd Reesing, Kansas | South Fla. | 12-SEP-08 | 51 | 34 | 1 | 381 | 11.21 | 3 | 0 | QB | JR |
| 33 | Chris Crane, Boston College | North Carolina St. | 04-OCT-08 | 51 | 34 | 1 | 428 | 12.59 | 2 | 0 | QB | SR |
| 33 | Sam Bradford, Oklahoma | Missouri | 06-DEC-08 | 49 | 34 | 0 | 384 | 11.29 | 2 | 0 | QB | SO |
| 33 | Thaddeus Lewis, Duke | North Carolina | 29-NOV-08 | 49 | 34 | 1 | 278 | 8.18 | 1 | 0 | QB | JR |
| 33 | Graham Harrell, Texas Tech | Kansas | 25-OCT-08 | 42 | 34 | 0 | 386 | 11.35 | 5 | 0 | QB | SR |
| 33 | Max Hall, BYU | UNI | 30-AUG-08 | 41 | 34 | 0 | 486 | 14.29 | 2 | 0 | QB | JR |
| 43 | Kevin Riley, California | Maryland | 13-SEP-08 | 58 | 33 | 1 | 423 | 12.82 | 3 | 0 | QB | SO |
| 43 | Chris Turner, Maryland | Boston College | 29-NOV-08 | 57 | 33 | 2 | 360 | 10.91 | 2 | 0 | QB | JR |
| 43 | Arkelon Hall, Memphis | Louisville | 10-OCT-08 | 55 | 33 | 1 | 350 | 10.61 | 2 | 0 | QB | JR |
| 43 | Graham Harrell, Texas Tech | Oklahoma | 22-NOV-08 | 55 | 33 | 1 | 361 | 10.94 | 3 | 0 | QB | SR |
| 43 | Aaron Opelt, Toledo | Michigan | 11-OCT-08 | 50 | 33 | 0 | 257 | 7.79 | 0 | 0 | QB | JR |
| 43 | Austin Davis, Southern Miss. | Auburn | 06-SEP-08 | 50 | 33 | 2 | 268 | 8.12 | 2 | 0 | QB | FR |
| 43 | Case Keenum, Houston | Southern U. | 30-AUG-08 | 43 | 33 | 0 | 392 | 11.88 | 5 | 0 | QB | SO |
| 50 | Austin Davis, Southern Miss. | Rice | 18-OCT-08 | 61 | 32 | 0 | 461 | 14.41 | 4 | 0 | QB | FR |
| 50 | Joe Ganz, Nebraska | Baylor | 25-OCT-08 | 46 | 32 | 0 | 336 | 10.5 | 3 | 0 | QB | SR |
| 50 | Giovanni Vizza, North Texas | Florida Int'l | 04-OCT-08 | 46 | 32 | 3 | 274 | 8.56 | 0 | 0 | QB | SO |
| 50 | Matt Grothe, South Fla. | Kansas | 12-SEP-08 | 45 | 32 | 0 | 338 | 10.56 | 2 | 0 | QB | JR |
| 50 | Riley Skinner, Wake Forest | Mississippi | 06-SEP-08 | 43 | 32 | 0 | 267 | 8.34 | 2 | 0 | QB | JR |
| 50 | Chase Daniel, Missouri | Iowa St. | 15-NOV-08 | 40 | 32 | 1 | 328 | 10.25 | 2 | 0 | QB | SR |
| 50 | Todd Reesing, Kansas | Louisiana Tech | 06-SEP-08 | 38 | 32 | 0 | 412 | 12.88 | 3 | 0 | QB | JR |
| 57 | Giovanni Vizza, North Texas | Troy | 25-OCT-08 | 52 | 31 | 3 | 246 | 7.94 | 1 | 0 | QB | SO |
| 57 | Adam Weber, Minnesota | Northwestern | 01-NOV-08 | 51 | 31 | 1 | 327 | 10.55 | 1 | 0 | QB | SO |
| 57 | Nate Davis, Ball St. | Buffalo | 05-DEC-08 | 48 | 31 | 1 | 351 | 11.32 | 1 | 0 | QB | JR |
| 57 | Jimmy Clausen, Notre Dame | North Carolina | 11-OCT-08 | 48 | 31 | 2 | 383 | 12.35 | 2 | 0 | QB | SO |
| 57 | Graham Harrell, Texas Tech | SMU | 13-SEP-08 | 48 | 31 | 0 | 418 | 13.48 | 5 | 0 | QB | SR |
| 57 | Austen Arnaud, Iowa St. | Kansas St. | 22-NOV-08 | 45 | 31 | 2 | 440 | 14.19 | 3 | 0 | QB | SO |
| 57 | Chase Daniel, Missouri | Texas | 18-OCT-08 | 41 | 31 | 1 | 318 | 10.26 | 2 | 0 | QB | SR |
| 57 | Jerrod Johnson, Texas A&M | Iowa St. | 25-OCT-08 | 39 | 31 | 0 | 381 | 12.29 | 4 | 0 | QB | SO |
| 57 | Chase Daniel, Missouri | Colorado | 25-OCT-08 | 37 | 31 | 1 | 302 | 9.74 | 5 | 0 | QB | SR |
| 66 | Case Keenum, Houston | Rice | 29-NOV-08 | 54 | 30 | 1 | 494 | 16.47 | 5 | 0 | QB | SO |
| 66 | Tim Hiller, Western Mich. | Nebraska | 30-AUG-08 | 49 | 30 | 1 | 342 | 11.4 | 2 | 0 | QB | JR |
| 66 | Max Hall, BYU | Arizona | 20-DEC-08 | 46 | 30 | 1 | 328 | 10.93 | 1 | 0 | QB | JR |
| 66 | Levi Brown, Troy | Western Ky. | 08-NOV-08 | 46 | 30 | 1 | 298 | 9.93 | 2 | 0 | QB | JR |
| 66 | Giovanni Vizza, North Texas | Tulsa | 06-SEP-08 | 45 | 30 | 0 | 247 | 8.23 | 2 | 0 | QB | SO |
| 66 | Dan LeFevour, Central Mich. | Ball St. | 19-NOV-08 | 44 | 30 | 1 | 345 | 11.5 | 2 | 0 | QB | JR |
| 66 | Sam Bradford, Oklahoma | Oklahoma St. | 29-NOV-08 | 44 | 30 | 0 | 370 | 12.33 | 4 | 0 | QB | SO |
| 66 | Chase Clement, Rice | Western Mich. | 30-DEC-08 | 44 | 30 | 0 | 307 | 10.23 | 3 | 0 | QB | SR |
| 66 | Chase Clement, Rice | Southern Miss. | 18-OCT-08 | 43 | 30 | 1 | 444 | 14.8 | 6 | 0 | QB | SR |
| 66 | Jamie Hampton, Troy | Ohio St. | 20-SEP-08 | 43 | 30 | 2 | 218 | 7.27 | 1 | 0 | QB | SO |
| 66 | Max Hall, BYU | Washington | 06-SEP-08 | 41 | 30 | 1 | 338 | 11.27 | 3 | 0 | QB | JR |
| 66 | Matt Grothe, South Fla. | Louisville | 25-OCT-08 | 40 | 30 | 2 | 344 | 11.47 | 2 | 0 | QB | JR |
| 66 | Chase Daniel, Missouri | Baylor | 01-NOV-08 | 38 | 30 | 2 | 318 | 10.6 | 3 | 0 | QB | SR |
| 66 | Brian Johnson, Utah | BYU | 22-NOV-08 | 36 | 30 | 0 | 303 | 10.1 | 4 | 0 | QB | SR |
| 80 | Ryan Lindley, San Diego St. | Notre Dame | 06-SEP-08 | 59 | 29 | 1 | 274 | 9.45 | 1 | 0 | QB | FR |
| 80 | Curtis Painter, Purdue | Notre Dame | 27-SEP-08 | 55 | 29 | 1 | 359 | 12.38 | 2 | 0 | QB | SR |
| 80 | Bill Stull, Pittsburgh | Bowling Green | 30-AUG-08 | 51 | 29 | 1 | 264 | 9.1 | 1 | 0 | QB | JR |
| 80 | Josh Freeman, Kansas St. | Oklahoma | 25-OCT-08 | 51 | 29 | 3 | 478 | 16.48 | 3 | 0 | QB | JR |
| 80 | Kellen Moore, Boise St. | Nevada | 22-NOV-08 | 48 | 29 | 3 | 414 | 14.28 | 3 | 0 | QB | FR |
| 80 | Daniel Raudabaugh, Miami (Ohio) | Toledo | 21-NOV-08 | 46 | 29 | 2 | 196 | 6.76 | 2 | 0 | QB | JR |
| 80 | Bo Levi Mitchell, SMU | UCF | 04-OCT-08 | 45 | 29 | 3 | 351 | 12.1 | 1 | 0 | QB | FR |
| 80 | Willie Tuitama, Arizona | Oregon | 15-NOV-08 | 45 | 29 | 2 | 328 | 11.31 | 2 | 1 | QB | SR |
| 80 | Giovanni Vizza, North Texas | La.-Lafayette | 11-OCT-08 | 44 | 29 | 1 | 361 | 12.45 | 2 | 0 | QB | SO |
| 80 | Tyler Sheehan, Bowling Green | Minnesota | 06-SEP-08 | 44 | 29 | 1 | 261 | 9 | 1 | 0 | QB | JR |
| 80 | Drew Willy, Buffalo | Connecticut | 03-JAN-09 | 43 | 29 | 1 | 213 | 7.34 | 0 | 0 | QB | SR |
| 80 | Drew Willy, Buffalo | Temple | 13-SEP-08 | 42 | 29 | 1 | 348 | 12 | 3 | 0 | QB | SR |
| 80 | Drew Willy, Buffalo | Bowling Green | 21-NOV-08 | 41 | 29 | 1 | 297 | 10.24 | 3 | 0 | QB | SR |
| 80 | Jerrod Johnson, Texas A&M | Kansas St. | 11-OCT-08 | 41 | 29 | 0 | 419 | 14.45 | 2 | 0 | QB | SO |
| 80 | Jimmy Clausen, Notre Dame | Stanford | 04-OCT-08 | 40 | 29 | 0 | 347 | 11.97 | 3 | 0 | QB | SO |
| 80 | Case Keenum, Houston | Tulane | 08-NOV-08 | 40 | 29 | 1 | 384 | 13.24 | 4 | 0 | QB | SO |
| 80 | Bo Levi Mitchell, SMU | Houston | 18-OCT-08 | 39 | 29 | 2 | 365 | 12.59 | 4 | 0 | QB | FR |
| 80 | Chase Holbrook, New Mexico St. | UTEP | 20-SEP-08 | 39 | 29 | 2 | 329 | 11.34 | 5 | 0 | QB | SR |
| 80 | Marc Verica, Virginia | Georgia Tech | 25-OCT-08 | 39 | 29 | 2 | 270 | 9.31 | 2 | 0 | QB | SO |
| 80 | Arkelon Hall, Memphis | Rice | 06-SEP-08 | 38 | 29 | 2 | 373 | 12.86 | 3 | 0 | QB | JR |
| 80 | Sam Bradford, Oklahoma | Cincinnati | 06-SEP-08 | 38 | 29 | 2 | 395 | 13.62 | 5 | 0 | QB | SO |
| 80 | Colt McCoy, Texas | Missouri | 18-OCT-08 | 32 | 29 | 0 | 337 | 11.62 | 2 | 0 | QB | JR |