| Rank | Player | Opponent | Sched Date | ATT | COMP | INT | NET | Average | TD | CM | Position | Class |
| 1 | Graham Harrell, Texas Tech | Eastern Wash. | 30-AUG-08 | 58 | 43 | 1 | 536 | 12.47 | 2 | 1 | QB | SR |
| 2 | Andy Schmitt, Eastern Mich. | Central Mich. | 28-NOV-08 | 80 | 58 | 1 | 516 | 8.9 | 5 | 0 | QB | JR |
| 3 | Case Keenum, Houston | Rice | 29-NOV-08 | 54 | 30 | 1 | 494 | 16.47 | 5 | 0 | QB | SO |
| 4 | Chase Holbrook, New Mexico St. | Louisiana Tech | 22-NOV-08 | 59 | 45 | 0 | 486 | 10.8 | 4 | 0 | QB | SR |
| 4 | Max Hall, BYU | UNI | 30-AUG-08 | 41 | 34 | 0 | 486 | 14.29 | 2 | 0 | QB | JR |
| 6 | Brian Brunner, Central Mich. | Indiana | 01-NOV-08 | 53 | 35 | 1 | 485 | 13.86 | 4 | 0 | QB | SR |
| 7 | Andy Schmitt, Eastern Mich. | Temple | 22-NOV-08 | 76 | 50 | 0 | 484 | 9.68 | 3 | 0 | QB | JR |
| 8 | Case Keenum, Houston | UTEP | 22-NOV-08 | 51 | 41 | 0 | 480 | 11.71 | 3 | 0 | QB | SO |
| 9 | Josh Freeman, Kansas St. | Oklahoma | 25-OCT-08 | 51 | 29 | 3 | 478 | 16.48 | 3 | 0 | QB | JR |
| 10 | Graham Harrell, Texas Tech | Texas | 01-NOV-08 | 53 | 36 | 0 | 474 | 13.17 | 2 | 0 | QB | SR |
| 11 | Tim Hiller, Western Mich. | Central Mich. | 18-OCT-08 | 53 | 38 | 0 | 471 | 12.39 | 2 | 0 | QB | JR |
| 12 | David Johnson, Tulsa | New Mexico | 20-SEP-08 | 39 | 24 | 2 | 469 | 19.54 | 6 | 0 | QB | SR |
| 13 | Sam Bradford, Oklahoma | Kansas | 18-OCT-08 | 53 | 36 | 0 | 468 | 13 | 3 | 0 | QB | SO |
| 14 | Juice Williams, Illinois | Minnesota | 11-OCT-08 | 41 | 26 | 1 | 462 | 17.77 | 2 | 0 | QB | JR |
| 15 | Austin Davis, Southern Miss. | Rice | 18-OCT-08 | 61 | 32 | 0 | 461 | 14.41 | 4 | 0 | QB | FR |
| 16 | Graham Harrell, Texas Tech | Oklahoma St. | 08-NOV-08 | 50 | 40 | 0 | 456 | 11.4 | 6 | 0 | QB | SR |
| 17 | Graham Harrell, Texas Tech | Kansas St. | 04-OCT-08 | 51 | 38 | 0 | 454 | 11.95 | 6 | 0 | QB | SR |
| 18 | Juice Williams, Illinois | Missouri | 30-AUG-08 | 42 | 26 | 2 | 451 | 17.35 | 5 | 1 | QB | JR |
| 19 | Graham Harrell, Texas Tech | Texas A&M | 18-OCT-08 | 56 | 44 | 2 | 450 | 10.23 | 3 | 0 | QB | SR |
| 20 | Curtis Painter, Purdue | Indiana | 22-NOV-08 | 54 | 38 | 0 | 448 | 11.79 | 5 | 0 | QB | SR |
| 21 | Mike Teel, Rutgers | Louisville | 04-DEC-08 | 26 | 21 | 0 | 447 | 21.29 | 7 | 0 | QB | SR |
| 22 | Chase Clement, Rice | Southern Miss. | 18-OCT-08 | 43 | 30 | 1 | 444 | 14.8 | 6 | 0 | QB | SR |
| 23 | Austen Arnaud, Iowa St. | Kansas St. | 22-NOV-08 | 45 | 31 | 2 | 440 | 14.19 | 3 | 0 | QB | SO |
| 24 | Chase Daniel, Missouri | Buffalo | 20-SEP-08 | 43 | 36 | 0 | 439 | 12.19 | 2 | 0 | QB | SR |
| 25 | David Johnson, Tulsa | UTEP | 18-OCT-08 | 27 | 21 | 1 | 434 | 20.67 | 5 | 0 | QB | SR |
| 26 | Ryan Lindley, San Diego St. | Idaho | 27-SEP-08 | 38 | 24 | 1 | 433 | 18.04 | 4 | 0 | QB | FR |
| 27 | Chris Crane, Boston College | North Carolina St. | 04-OCT-08 | 51 | 34 | 1 | 428 | 12.59 | 2 | 0 | QB | SR |
| 28 | Kevin Riley, California | Maryland | 13-SEP-08 | 58 | 33 | 1 | 423 | 12.82 | 3 | 0 | QB | SO |
| 29 | Jerrod Johnson, Texas A&M | Kansas St. | 11-OCT-08 | 41 | 29 | 0 | 419 | 14.45 | 2 | 0 | QB | SO |
| 30 | Graham Harrell, Texas Tech | SMU | 13-SEP-08 | 48 | 31 | 0 | 418 | 13.48 | 5 | 0 | QB | SR |
| 30 | David Johnson, Tulsa | North Texas | 06-SEP-08 | 33 | 25 | 0 | 418 | 16.72 | 6 | 0 | QB | SR |
| 32 | Colt McCoy, Texas | Ohio St. | 05-JAN-09 | 58 | 41 | 1 | 414 | 10.1 | 2 | 0 | QB | JR |
| 32 | Kellen Moore, Boise St. | Nevada | 22-NOV-08 | 48 | 29 | 3 | 414 | 14.28 | 3 | 0 | QB | FR |
| 34 | Mark Sanchez, Southern California | Penn St. | 01-JAN-09 | 35 | 28 | 0 | 413 | 14.75 | 4 | 0 | QB | JR |
| 35 | Todd Reesing, Kansas | Louisiana Tech | 06-SEP-08 | 38 | 32 | 0 | 412 | 12.88 | 3 | 0 | QB | JR |
| 36 | Sam Bradford, Oklahoma | TCU | 27-SEP-08 | 34 | 19 | 0 | 411 | 21.63 | 4 | 0 | QB | SO |
| 37 | Trevor Vittatoe, UTEP | SMU | 15-NOV-08 | 31 | 21 | 0 | 410 | 19.52 | 3 | 0 | QB | SO |
| 38 | Chase Holbrook, New Mexico St. | Nevada | 11-OCT-08 | 47 | 28 | 1 | 409 | 14.61 | 3 | 0 | QB | SR |
| 39 | Matthew Stafford, Georgia | Georgia Tech | 29-NOV-08 | 39 | 24 | 1 | 407 | 16.96 | 5 | 0 | QB | JR |
| 40 | Chase Daniel, Missouri | Nevada | 13-SEP-08 | 28 | 23 | 0 | 405 | 17.61 | 4 | 0 | QB | SR |
| 41 | Lyle Moevao, Oregon St. | Stanford | 28-AUG-08 | 54 | 34 | 2 | 404 | 11.88 | 3 | 1 | QB | JR |
| 41 | Case Keenum, Houston | SMU | 18-OCT-08 | 36 | 28 | 1 | 404 | 14.43 | 2 | 1 | QB | SO |
| 43 | Case Keenum, Houston | Tulsa | 15-NOV-08 | 37 | 24 | 0 | 402 | 16.75 | 6 | 0 | QB | SO |
| 44 | Case Keenum, Houston | East Carolina | 27-SEP-08 | 45 | 37 | 1 | 401 | 10.84 | 3 | 0 | QB | SO |
| 44 | Jimmy Clausen, Notre Dame | Hawaii | 24-DEC-08 | 26 | 22 | 0 | 401 | 18.23 | 5 | 0 | QB | SO |
| 46 | Paul McCall, Florida Int'l | Fla. Atlantic | 29-NOV-08 | 48 | 27 | 1 | 400 | 14.81 | 4 | 0 | QB | JR |
| 47 | Colin Kaepernick, Nevada | Louisiana Tech | 29-NOV-08 | 42 | 24 | 1 | 397 | 16.54 | 4 | 0 | QB | SO |
| 48 | Sam Bradford, Oklahoma | Cincinnati | 06-SEP-08 | 38 | 29 | 2 | 395 | 13.62 | 5 | 0 | QB | SO |
| 48 | Zac Robinson, Oklahoma St. | Iowa St. | 01-NOV-08 | 27 | 18 | 1 | 395 | 21.94 | 5 | 0 | QB | JR |
| 50 | Chase Holbrook, New Mexico St. | Hawaii | 08-NOV-08 | 38 | 24 | 2 | 394 | 16.42 | 4 | 0 | QB | SR |
| 51 | Case Keenum, Houston | Southern U. | 30-AUG-08 | 43 | 33 | 0 | 392 | 11.88 | 5 | 0 | QB | SO |
| 52 | Levi Brown, Troy | North Texas | 25-OCT-08 | 50 | 40 | 0 | 391 | 9.78 | 2 | 0 | QB | JR |
| 52 | Colt McCoy, Texas | Oklahoma St. | 25-OCT-08 | 45 | 38 | 1 | 391 | 10.29 | 2 | 0 | QB | JR |
| 54 | Chase Daniel, Missouri | Oklahoma St. | 11-OCT-08 | 52 | 39 | 3 | 390 | 10 | 1 | 0 | QB | SR |
| 55 | Rusty Smith, Fla. Atlantic | Florida Int'l | 29-NOV-08 | 50 | 25 | 1 | 389 | 15.56 | 5 | 1 | QB | JR |
| 55 | Max Hall, BYU | Colorado St. | 01-NOV-08 | 35 | 28 | 1 | 389 | 13.89 | 5 | 0 | QB | JR |
| 57 | Rudy Carpenter, Arizona St. | Northern Ariz. | 30-AUG-08 | 28 | 22 | 0 | 388 | 17.64 | 1 | 0 | QB | SR |
| 58 | Case Keenum, Houston | Oklahoma St. | 06-SEP-08 | 61 | 35 | 0 | 387 | 11.06 | 4 | 0 | QB | SO |
| 58 | Ryan Lindley, San Diego St. | UNLV | 22-NOV-08 | 50 | 35 | 0 | 387 | 11.06 | 2 | 0 | QB | FR |
| 58 | Sam Bradford, Oklahoma | Texas | 11-OCT-08 | 39 | 28 | 2 | 387 | 13.82 | 5 | 0 | QB | SO |
| 61 | Graham Harrell, Texas Tech | Kansas | 25-OCT-08 | 42 | 34 | 0 | 386 | 11.35 | 5 | 0 | QB | SR |
| 61 | Kellen Moore, Boise St. | Oregon | 20-SEP-08 | 37 | 25 | 1 | 386 | 15.44 | 3 | 0 | QB | FR |
| 63 | Case Keenum, Houston | Colorado St. | 20-SEP-08 | 55 | 38 | 3 | 385 | 10.13 | 3 | 1 | QB | SO |
| 63 | Casey Dick, Arkansas | Tulsa | 01-NOV-08 | 38 | 25 | 1 | 385 | 15.4 | 1 | 0 | QB | SR |
| 65 | Sam Bradford, Oklahoma | Missouri | 06-DEC-08 | 49 | 34 | 0 | 384 | 11.29 | 2 | 0 | QB | SO |
| 65 | Case Keenum, Houston | Tulane | 08-NOV-08 | 40 | 29 | 1 | 384 | 13.24 | 4 | 0 | QB | SO |
| 65 | Chase Clement, Rice | Army | 08-NOV-08 | 28 | 21 | 0 | 384 | 18.29 | 3 | 0 | QB | SR |
| 68 | Jimmy Clausen, Notre Dame | North Carolina | 11-OCT-08 | 48 | 31 | 2 | 383 | 12.35 | 2 | 0 | QB | SO |
| 69 | Chase Holbrook, New Mexico St. | New Mexico | 27-SEP-08 | 38 | 24 | 1 | 382 | 15.92 | 3 | 0 | QB | SR |
| 70 | Todd Reesing, Kansas | South Fla. | 12-SEP-08 | 51 | 34 | 1 | 381 | 11.21 | 3 | 0 | QB | JR |
| 70 | Chase Clement, Rice | Houston | 29-NOV-08 | 41 | 28 | 0 | 381 | 13.61 | 5 | 0 | QB | SR |
| 70 | Jerrod Johnson, Texas A&M | Iowa St. | 25-OCT-08 | 39 | 31 | 0 | 381 | 12.29 | 4 | 0 | QB | SO |
| 73 | Dan LeFevour, Central Mich. | Eastern Mich. | 28-NOV-08 | 38 | 22 | 1 | 378 | 17.18 | 4 | 0 | QB | JR |
| 74 | Matthew Stafford, Georgia | Kentucky | 08-NOV-08 | 27 | 17 | 0 | 376 | 22.12 | 3 | 0 | QB | JR |
| 75 | Todd Reesing, Kansas | Missouri | 29-NOV-08 | 51 | 37 | 2 | 375 | 10.14 | 4 | 0 | QB | JR |
| 76 | Lyle Moevao, Oregon St. | Oregon | 29-NOV-08 | 51 | 27 | 2 | 374 | 13.85 | 5 | 0 | QB | JR |
| 77 | Arkelon Hall, Memphis | Rice | 06-SEP-08 | 38 | 29 | 2 | 373 | 12.86 | 3 | 0 | QB | JR |
| 78 | Chase Clement, Rice | UTEP | 01-NOV-08 | 41 | 28 | 0 | 372 | 13.29 | 5 | 0 | QB | SR |
| 78 | Sam Bradford, Oklahoma | Baylor | 04-OCT-08 | 31 | 23 | 1 | 372 | 16.17 | 2 | 0 | QB | SO |
| 80 | Austen Arnaud, Iowa St. | Texas A&M | 25-OCT-08 | 41 | 26 | 0 | 371 | 14.27 | 1 | 1 | QB | SO |
| 81 | Colin Kaepernick, Nevada | Maryland | 30-DEC-08 | 47 | 24 | 2 | 370 | 15.42 | 3 | 0 | QB | SO |
| 81 | Sam Bradford, Oklahoma | Oklahoma St. | 29-NOV-08 | 44 | 30 | 0 | 370 | 12.33 | 4 | 0 | QB | SO |
| 81 | Bo Levi Mitchell, SMU | Texas St. | 06-SEP-08 | 37 | 24 | 0 | 370 | 15.42 | 5 | 0 | QB | FR |
| 81 | Adam DiMichele, Temple | Eastern Mich. | 22-NOV-08 | 37 | 21 | 0 | 370 | 17.62 | 6 | 0 | QB | SR |
| 85 | Bo Levi Mitchell, SMU | Houston | 18-OCT-08 | 39 | 29 | 2 | 365 | 12.59 | 4 | 0 | QB | FR |
| 85 | Boo Jackson, Ohio | Central Mich. | 13-SEP-08 | 31 | 17 | 0 | 365 | 21.47 | 3 | 0 | QB | JR |
| 87 | Graham Harrell, Texas Tech | Mississippi | 02-JAN-09 | 58 | 36 | 2 | 364 | 10.11 | 4 | 0 | QB | SR |
| 87 | Arkelon Hall, Memphis | Marshall | 13-SEP-08 | 51 | 28 | 0 | 364 | 13 | 0 | 0 | QB | JR |
| 89 | Giovanni Vizza, North Texas | La.-Monroe | 18-OCT-08 | 61 | 37 | 0 | 362 | 9.78 | 2 | 0 | QB | SO |
| 89 | Case Keenum, Houston | Air Force | 13-SEP-08 | 57 | 34 | 1 | 362 | 10.65 | 4 | 0 | QB | SO |
| 89 | Trevor Vittatoe, UTEP | Houston | 22-NOV-08 | 45 | 27 | 0 | 362 | 13.41 | 4 | 0 | QB | SO |
| 89 | Kellen Moore, Boise St. | Utah St. | 08-NOV-08 | 36 | 27 | 1 | 362 | 13.41 | 2 | 0 | QB | FR |
| 93 | Graham Harrell, Texas Tech | Oklahoma | 22-NOV-08 | 55 | 33 | 1 | 361 | 10.94 | 3 | 0 | QB | SR |
| 93 | Giovanni Vizza, North Texas | La.-Lafayette | 11-OCT-08 | 44 | 29 | 1 | 361 | 12.45 | 2 | 0 | QB | SO |
| 93 | Dan LeFevour, Central Mich. | Ohio | 13-SEP-08 | 42 | 28 | 0 | 361 | 12.89 | 0 | 0 | QB | JR |
| 93 | Mike Teel, Rutgers | Pittsburgh | 25-OCT-08 | 21 | 14 | 1 | 361 | 25.79 | 6 | 0 | QB | SR |
| 97 | Chris Turner, Maryland | Boston College | 29-NOV-08 | 57 | 33 | 2 | 360 | 10.91 | 2 | 0 | QB | JR |
| 97 | Case Keenum, Houston | UAB | 09-OCT-08 | 36 | 24 | 0 | 360 | 15 | 2 | 0 | QB | SO |
| 99 | Curtis Painter, Purdue | Notre Dame | 27-SEP-08 | 55 | 29 | 1 | 359 | 12.38 | 2 | 0 | QB | SR |
| 99 | Mike Teel, Rutgers | Army | 22-NOV-08 | 33 | 23 | 0 | 359 | 15.61 | 1 | 0 | QB | SR |