| Rank | Player | Opponent | Sched Date | Carries | Gain | Loss | Net | TD | Average | Position | Class |
| 1 | Javon Ringer, Michigan St. | Indiana | 27-SEP-08 | 44 | 216 | 18 | 198 | 1 | 4.5 | RB | SR |
| 2 | Javon Ringer, Michigan St. | Fla. Atlantic | 13-SEP-08 | 43 | 291 | 9 | 282 | 2 | 6.56 | RB | SR |
| 3 | Ricky Dobbs, Navy | SMU | 25-OCT-08 | 42 | 227 | 3 | 224 | 4 | 5.33 | QB | SO |
| 4 | Javon Ringer, Michigan St. | Notre Dame | 20-SEP-08 | 39 | 217 | 16 | 201 | 2 | 5.15 | RB | SR |
| 5 | Andre Anderson, Tulane | La.-Monroe | 20-SEP-08 | 38 | 165 | 8 | 157 | 1 | 4.13 | RB | JR |
| 6 | Javon Ringer, Michigan St. | Michigan | 25-OCT-08 | 37 | 197 | 3 | 194 | 2 | 5.24 | RB | SR |
| 6 | Jacquizz Rodgers, Oregon St. | Southern California | 25-SEP-08 | 37 | 194 | 8 | 186 | 2 | 5.03 | RB | FR |
| 6 | James Starks, Buffalo | Akron | 13-NOV-08 | 37 | 153 | 2 | 151 | 3 | 4.08 | RB | JR |
| 6 | Paul Baker, New Mexico | New Mexico St. | 27-SEP-08 | 37 | 147 | 1 | 146 | 1 | 3.95 | RB | SR |
| 10 | Andre Anderson, Tulane | SMU | 25-SEP-08 | 36 | 219 | 0 | 219 | 1 | 6.08 | RB | JR |
| 10 | Donald Brown, Connecticut | Temple | 06-SEP-08 | 36 | 220 | 6 | 214 | 1 | 5.94 | RB | JR |
| 12 | Michael Smith, Arkansas | Kentucky | 18-OCT-08 | 35 | 196 | 4 | 192 | 1 | 5.49 | RB | JR |
| 12 | Michael Smith, Arkansas | Auburn | 11-OCT-08 | 35 | 185 | 9 | 176 | 1 | 5.03 | RB | JR |
| 12 | Javon Ringer, Michigan St. | Northwestern | 11-OCT-08 | 35 | 127 | 3 | 124 | 2 | 3.54 | RB | SR |
| 15 | Damion Fletcher, Southern Miss. | UTEP | 04-OCT-08 | 34 | 262 | 2 | 260 | 1 | 7.65 | RB | JR |
| 15 | Donald Brown, Connecticut | Pittsburgh | 06-DEC-08 | 34 | 201 | 12 | 189 | 1 | 5.56 | RB | JR |
| 15 | Eugene Jarvis, Kent St. | Temple | 12-NOV-08 | 34 | 201 | 16 | 185 | 1 | 5.44 | RB | JR |
| 15 | Donald Brown, Connecticut | Baylor | 19-SEP-08 | 34 | 152 | 2 | 150 | 2 | 4.41 | RB | JR |
| 15 | Javon Ringer, Michigan St. | Eastern Mich. | 06-SEP-08 | 34 | 138 | 3 | 135 | 5 | 3.97 | RB | SR |
| 15 | Chip Bowden, Army | Texas A&M | 27-SEP-08 | 34 | 140 | 12 | 128 | 0 | 3.76 | QB | SO |
| 15 | Dennis Kennedy, Akron | Ohio | 22-NOV-08 | 34 | 124 | 1 | 123 | 4 | 3.62 | RB | SR |
| 22 | Tarrion Adams, Tulsa | Tulane | 22-NOV-08 | 33 | 328 | 5 | 323 | 1 | 9.79 | RB | SR |
| 22 | Gartrell Johnson III, Colorado St. | UNLV | 04-OCT-08 | 33 | 191 | 0 | 191 | 3 | 5.79 | RB | SR |
| 22 | Donald Brown, Connecticut | Louisville | 26-SEP-08 | 33 | 203 | 13 | 190 | 1 | 5.76 | RB | JR |
| 22 | LeSean McCoy, Pittsburgh | West Virginia | 28-NOV-08 | 33 | 187 | 4 | 183 | 2 | 5.55 | RB | SO |
| 22 | Curtis Brinkley, Syracuse | Louisville | 01-NOV-08 | 33 | 169 | 3 | 166 | 1 | 5.03 | RB | SR |
| 22 | Donald Brown, Connecticut | North Carolina | 04-OCT-08 | 33 | 170 | 9 | 161 | 1 | 4.88 | RB | JR |
| 22 | Brynn Harvey, UCF | Marshall | 15-NOV-08 | 33 | 158 | 8 | 150 | 1 | 4.55 | RB | FR |
| 22 | Andre Anderson, Tulane | East Carolina | 13-SEP-08 | 33 | 92 | 10 | 82 | 2 | 2.48 | RB | JR |
| 30 | Darren Evans, Virginia Tech | Maryland | 06-NOV-08 | 32 | 256 | 3 | 253 | 1 | 7.91 | RB | FR |
| 30 | LeSean McCoy, Pittsburgh | Notre Dame | 01-NOV-08 | 32 | 183 | 14 | 169 | 1 | 5.28 | RB | SO |
| 30 | Javon Ringer, Michigan St. | Purdue | 08-NOV-08 | 32 | 133 | 12 | 121 | 2 | 3.78 | RB | SR |
| 30 | MiQuale Lewis, Ball St. | Western Mich. | 25-NOV-08 | 32 | 126 | 6 | 120 | 3 | 3.75 | RB | JR |
| 30 | Devin Moore, Wyoming | Tennessee | 08-NOV-08 | 32 | 104 | 6 | 98 | 0 | 3.06 | RB | SR |
| 35 | James Starks, Buffalo | UTEP | 28-AUG-08 | 31 | 179 | 0 | 179 | 0 | 5.77 | RB | JR |
| 35 | MiQuale Lewis, Ball St. | Toledo | 04-OCT-08 | 31 | 160 | 3 | 157 | 2 | 5.06 | RB | JR |
| 35 | Jacquizz Rodgers, Oregon St. | UCLA | 08-NOV-08 | 31 | 147 | 3 | 144 | 1 | 4.65 | RB | FR |
| 35 | Chris Wells, Ohio St. | Michigan St. | 18-OCT-08 | 31 | 149 | 9 | 140 | 2 | 4.52 | RB | JR |
| 35 | Jake Sharp, Kansas | Colorado | 11-OCT-08 | 31 | 122 | 4 | 118 | 3 | 3.81 | RB | JR |
| 35 | Darren Evans, Virginia Tech | Boston College | 06-DEC-08 | 31 | 129 | 15 | 114 | 1 | 3.68 | RB | FR |
| 35 | Jarod Bryant, Navy | Ball St. | 05-SEP-08 | 31 | 109 | 15 | 94 | 2 | 3.03 | QB | SR |
| 42 | Shonn Greene, Iowa | Purdue | 15-NOV-08 | 30 | 215 | 4 | 211 | 2 | 7.03 | RB | JR |
| 42 | James Starks, Buffalo | Ohio | 28-OCT-08 | 30 | 186 | 1 | 185 | 2 | 6.17 | RB | JR |
| 42 | Shonn Greene, Iowa | Michigan St. | 04-OCT-08 | 30 | 165 | 8 | 157 | 0 | 5.23 | RB | JR |
| 42 | Dennis Kennedy, Akron | Toledo | 05-NOV-08 | 30 | 155 | 2 | 153 | 1 | 5.1 | RB | SR |
| 42 | Shaun Draughn, North Carolina | Virginia | 18-OCT-08 | 30 | 140 | 2 | 138 | 0 | 4.6 | RB | SO |
| 42 | Jacquizz Rodgers, Oregon St. | Arizona St. | 01-NOV-08 | 30 | 143 | 10 | 133 | 0 | 4.43 | RB | FR |
| 42 | MiQuale Lewis, Ball St. | Buffalo | 05-DEC-08 | 30 | 138 | 7 | 131 | 2 | 4.37 | RB | JR |
| 42 | Gartrell Johnson III, Colorado St. | New Mexico | 15-NOV-08 | 30 | 131 | 4 | 127 | 1 | 4.23 | RB | SR |
| 42 | Tarrion Adams, Tulsa | Marshall | 29-NOV-08 | 30 | 123 | 0 | 123 | 3 | 4.1 | RB | SR |
| 42 | Kory Sheets, Purdue | Michigan | 01-NOV-08 | 30 | 128 | 10 | 118 | 3 | 3.93 | RB | SR |
| 42 | Darius Marshall, Marshall | Southern Miss. | 20-SEP-08 | 30 | 132 | 16 | 116 | 1 | 3.87 | RB | SO |
| 53 | Donald Brown, Connecticut | Buffalo | 03-JAN-09 | 29 | 264 | 3 | 261 | 1 | 9 | RB | JR |
| 53 | Andre Anderson, Tulane | UTEP | 11-OCT-08 | 29 | 260 | 5 | 255 | 2 | 8.79 | RB | JR |
| 53 | Collin Mooney, Army | Eastern Mich. | 11-OCT-08 | 29 | 229 | 0 | 229 | 0 | 7.9 | RB | SR |
| 53 | Dennis Kennedy, Akron | Bowling Green | 11-OCT-08 | 29 | 184 | 2 | 182 | 2 | 6.28 | RB | SR |
| 53 | Kory Sheets, Purdue | Oregon | 13-SEP-08 | 29 | 183 | 3 | 180 | 2 | 6.21 | RB | SR |
| 53 | Curtis Steele, Memphis | Southern Miss. | 25-OCT-08 | 29 | 180 | 2 | 178 | 2 | 6.14 | RB | JR |
| 53 | MiQuale Lewis, Ball St. | Indiana | 20-SEP-08 | 29 | 170 | 4 | 166 | 4 | 5.72 | RB | JR |
| 53 | Brandon West, Western Mich. | Eastern Mich. | 01-NOV-08 | 29 | 170 | 4 | 166 | 1 | 5.72 | RB | JR |
| 53 | Donald Brown, Connecticut | Cincinnati | 25-OCT-08 | 29 | 157 | 7 | 150 | 2 | 5.17 | RB | JR |
| 53 | Kordell Young, Rutgers | Syracuse | 08-NOV-08 | 29 | 149 | 6 | 143 | 1 | 4.93 | RB | SO |
| 53 | Rodney Stewart, Colorado | Kansas St. | 18-OCT-08 | 29 | 147 | 6 | 141 | 1 | 4.86 | RB | FR |
| 53 | Lamark Brown, Kansas St. | La.-Lafayette | 27-SEP-08 | 29 | 142 | 5 | 137 | 1 | 4.72 | RB | SO |
| 53 | Da'Rel Scott, Maryland | North Carolina | 15-NOV-08 | 29 | 134 | 5 | 129 | 1 | 4.45 | RB | SO |
| 53 | Shonn Greene, Iowa | South Carolina | 01-JAN-09 | 29 | 125 | 4 | 121 | 3 | 4.17 | RB | JR |
| 53 | Dan LeFevour, Central Mich. | Northern Ill. | 12-NOV-08 | 29 | 137 | 16 | 121 | 2 | 4.17 | QB | JR |
| 53 | Tyrell Sutton, Northwestern | Missouri | 29-DEC-08 | 29 | 116 | 2 | 114 | 0 | 3.93 | RB | SR |
| 53 | Shaun Draughn, North Carolina | Duke | 29-NOV-08 | 29 | 119 | 9 | 110 | 1 | 3.79 | RB | SO |
| 53 | Kee-ayre Griffin, Temple | Navy | 01-NOV-08 | 29 | 99 | 12 | 87 | 1 | 3 | DB | FR |
| 53 | Mike Kafka, Northwestern | Ohio St. | 08-NOV-08 | 29 | 126 | 43 | 83 | 1 | 2.86 | QB | JR |
| 53 | DeLeon Eskridge, Minnesota | Indiana | 04-OCT-08 | 29 | 76 | 2 | 74 | 0 | 2.55 | RB | FR |
| 73 | Morgan Williams, Toledo | Miami (Ohio) | 21-NOV-08 | 28 | 332 | 2 | 330 | 3 | 11.79 | RB | FR |
| 73 | Vai Taua, Nevada | Fresno St. | 07-NOV-08 | 28 | 268 | 5 | 263 | 1 | 9.39 | RB | SO |
| 73 | DuJuan Harris, Troy | La.-Lafayette | 22-NOV-08 | 28 | 237 | 3 | 234 | 2 | 8.36 | RB | SO |
| 73 | Nicolas Grigsby, Arizona | Washington St. | 08-NOV-08 | 28 | 197 | 8 | 189 | 1 | 6.75 | RB | SO |
| 73 | MiQuale Lewis, Ball St. | Central Mich. | 19-NOV-08 | 28 | 180 | 3 | 177 | 0 | 6.32 | RB | JR |
| 73 | Rodney Stewart, Colorado | West Virginia | 18-SEP-08 | 28 | 168 | 2 | 166 | 0 | 5.93 | RB | FR |
| 73 | MiQuale Lewis, Ball St. | Akron | 13-SEP-08 | 28 | 158 | 4 | 154 | 2 | 5.5 | RB | JR |
| 73 | Darren Evans, Virginia Tech | Cincinnati | 01-JAN-09 | 28 | 163 | 10 | 153 | 1 | 5.46 | RB | FR |
| 73 | Josh Nesbitt, Georgia Tech | Virginia Tech | 13-SEP-08 | 28 | 162 | 11 | 151 | 1 | 5.39 | QB | SO |
| 73 | LeSean McCoy, Pittsburgh | Syracuse | 27-SEP-08 | 28 | 151 | 2 | 149 | 0 | 5.32 | RB | SO |
| 73 | Curtis Brinkley, Syracuse | West Virginia | 11-OCT-08 | 28 | 144 | 0 | 144 | 0 | 5.14 | RB | SR |
| 73 | LeSean McCoy, Pittsburgh | South Fla. | 02-OCT-08 | 28 | 144 | 2 | 142 | 2 | 5.07 | RB | SO |
| 73 | Chris Wells, Ohio St. | Northwestern | 08-NOV-08 | 28 | 159 | 19 | 140 | 2 | 5 | RB | JR |
| 73 | Norman Whitley, East Carolina | UCF | 02-NOV-08 | 28 | 142 | 7 | 135 | 1 | 4.82 | RB | SO |
| 73 | James Starks, Buffalo | Western Mich. | 11-OCT-08 | 28 | 130 | 5 | 125 | 3 | 4.46 | RB | JR |
| 73 | Tarrion Adams, Tulsa | East Carolina | 06-DEC-08 | 28 | 121 | 1 | 120 | 2 | 4.29 | RB | SR |
| 73 | Shonn Greene, Iowa | Penn St. | 08-NOV-08 | 28 | 121 | 4 | 117 | 2 | 4.18 | RB | JR |
| 73 | Aaron Winchester, Western Mich. | Toledo | 15-NOV-08 | 28 | 113 | 2 | 111 | 0 | 3.96 | RB | FR |
| 73 | Donald Brown, Connecticut | South Fla. | 23-NOV-08 | 28 | 101 | 5 | 96 | 0 | 3.43 | RB | JR |
| 73 | Tony Dixon, Kentucky | East Carolina | 02-JAN-09 | 28 | 96 | 7 | 89 | 0 | 3.18 | RB | SR |
| 73 | Kordell Young, Rutgers | Connecticut | 18-OCT-08 | 28 | 89 | 9 | 80 | 1 | 2.86 | RB | SO |
| 94 | Gartrell Johnson III, Colorado St. | Fresno St. | 20-DEC-08 | 27 | 286 | 1 | 285 | 2 | 10.56 | RB | SR |
| 94 | Mike Kafka, Northwestern | Minnesota | 01-NOV-08 | 27 | 243 | 26 | 217 | 0 | 8.04 | QB | JR |
| 94 | Jared Tew, Air Force | Houston | 31-DEC-08 | 27 | 149 | 0 | 149 | 2 | 5.52 | RB | SO |
| 94 | Jacquizz Rodgers, Oregon St. | California | 15-NOV-08 | 27 | 152 | 8 | 144 | 1 | 5.33 | RB | FR |
| 94 | Charles Scott, LSU | Mississippi St. | 27-SEP-08 | 27 | 142 | 1 | 141 | 2 | 5.22 | RB | JR |
| 94 | Darius Marshall, Marshall | Memphis | 13-SEP-08 | 27 | 150 | 10 | 140 | 1 | 5.19 | RB | SO |
| 94 | Toby Gerhart, Stanford | UCLA | 18-OCT-08 | 27 | 138 | 0 | 138 | 2 | 5.11 | RB | JR |
| 94 | Marcus Jackson, TCU | San Diego St. | 04-OCT-08 | 27 | 152 | 21 | 131 | 2 | 4.85 | QB | JR |
| 94 | Anthony Dixon, Mississippi St. | Middle Tenn. St. | 25-OCT-08 | 27 | 141 | 15 | 126 | 3 | 4.67 | RB | JR |
| 94 | Chris Brown, Oklahoma | Missouri | 06-DEC-08 | 27 | 122 | 0 | 122 | 3 | 4.52 | RB | JR |
| 94 | Rodney Ferguson, New Mexico | Tulsa | 20-SEP-08 | 27 | 125 | 3 | 122 | 1 | 4.52 | RB | SR |
| 94 | Brandon Simmons, East Carolina | UTEP | 28-NOV-08 | 27 | 115 | 4 | 111 | 3 | 4.11 | RB | SR |
| 94 | Brandon Pendergrass, Wake Forest | Virginia | 08-NOV-08 | 27 | 114 | 4 | 110 | 1 | 4.07 | RB | SO |
| 94 | Frank Summers, UNLV | Iowa St. | 20-SEP-08 | 27 | 119 | 10 | 109 | 1 | 4.04 | RB | SR |
| 94 | Ben Tate, Auburn | Vanderbilt | 04-OCT-08 | 27 | 118 | 10 | 108 | 0 | 4 | RB | JR |
| 94 | Donald Brown, Connecticut | Rutgers | 18-OCT-08 | 27 | 122 | 15 | 107 | 0 | 3.96 | RB | JR |
| 94 | Anthony Dixon, Mississippi St. | Vanderbilt | 11-OCT-08 | 27 | 114 | 7 | 107 | 0 | 3.96 | RB | JR |
| 94 | Knowshon Moreno, Georgia | Tennessee | 11-OCT-08 | 27 | 111 | 10 | 101 | 0 | 3.74 | RB | SO |
| 94 | Shane Vereen, California | Arizona St. | 04-OCT-08 | 27 | 98 | 5 | 93 | 0 | 3.44 | RB | FR |
| 94 | Phillip Tanner, Middle Tenn. St. | Western Ky. | 15-NOV-08 | 27 | 114 | 22 | 92 | 1 | 3.41 | RB | JR |
| 94 | Antone Smith, Florida St. | Miami (Fla.) | 04-OCT-08 | 27 | 105 | 13 | 92 | 4 | 3.41 | RB | SR |
| 94 | Javon Ringer, Michigan St. | California | 30-AUG-08 | 27 | 88 | 7 | 81 | 2 | 3 | RB | SR |
| 94 | Tyrell Sutton, Northwestern | Indiana | 25-OCT-08 | 27 | 85 | 8 | 77 | 1 | 2.85 | RB | SR |
| 94 | Brad McGuire, La.-Lafayette | Arkansas St. | 18-OCT-08 | 27 | 90 | 36 | 54 | 2 | 2 | QB | SO |