| Rank | Player | Opponent | Sched Date | Yards | Plays | Average | TDR | Position | Class |
| 1 | Andy Schmitt, Eastern Mich. | Central Mich. | 28-NOV-08 | 554 | 89 | 6.22 | 1 | QB | JR |
| 2 | Andy Schmitt, Eastern Mich. | Temple | 22-NOV-08 | 504 | 83 | 6.07 | 2 | QB | JR |
| 3 | Levi Brown, Troy | LSU | 15-NOV-08 | 314 | 74 | 4.24 | 0 | QB | JR |
| 4 | Austin Davis, Southern Miss. | Rice | 18-OCT-08 | 446 | 71 | 6.28 | 0 | QB | FR |
| 5 | Case Keenum, Houston | Oklahoma St. | 06-SEP-08 | 468 | 70 | 6.69 | 0 | QB | SO |
| 6 | C.J. Bacher, Northwestern | Michigan St. | 11-OCT-08 | 315 | 69 | 4.57 | 1 | QB | SR |
| 7 | Dan LeFevour, Central Mich. | Ball St. | 19-NOV-08 | 420 | 68 | 6.18 | 0 | QB | JR |
| 7 | Dan LeFevour, Central Mich. | Purdue | 20-SEP-08 | 403 | 68 | 5.93 | 1 | QB | JR |
| 7 | Tim Hiller, Western Mich. | Buffalo | 11-OCT-08 | 338 | 68 | 4.97 | 0 | QB | JR |
| 10 | Chase Holbrook, New Mexico St. | Louisiana Tech | 22-NOV-08 | 472 | 67 | 7.04 | 0 | QB | SR |
| 10 | Case Keenum, Houston | Air Force | 13-SEP-08 | 437 | 67 | 6.52 | 0 | QB | SO |
| 10 | Adam Weber, Minnesota | Northwestern | 01-NOV-08 | 380 | 67 | 5.67 | 0 | QB | SO |
| 13 | Colt McCoy, Texas | Ohio St. | 05-JAN-09 | 399 | 66 | 6.05 | 1 | QB | JR |
| 13 | Joe Webb, UAB | Fla. Atlantic | 06-SEP-08 | 392 | 66 | 5.94 | 0 | QB | JR |
| 13 | Zac Robinson, Oklahoma St. | Oregon | 30-DEC-08 | 383 | 66 | 5.8 | 1 | QB | JR |
| 13 | Arkelon Hall, Memphis | Louisville | 10-OCT-08 | 372 | 66 | 5.64 | 2 | QB | JR |
| 13 | Colin Kaepernick, Nevada | Boise St. | 22-NOV-08 | 311 | 66 | 4.71 | 0 | QB | SO |
| 13 | Giovanni Vizza, North Texas | Troy | 25-OCT-08 | 240 | 66 | 3.64 | 0 | QB | SO |
| 19 | Brian Brunner, Central Mich. | Indiana | 01-NOV-08 | 460 | 65 | 7.08 | 1 | QB | SR |
| 19 | Kevin Riley, California | Maryland | 13-SEP-08 | 400 | 65 | 6.15 | 0 | QB | SO |
| 19 | Giovanni Vizza, North Texas | La.-Monroe | 18-OCT-08 | 360 | 65 | 5.54 | 0 | QB | SO |
| 19 | Joe Webb, UAB | Houston | 09-OCT-08 | 306 | 65 | 4.71 | 1 | QB | JR |
| 23 | Josh Freeman, Kansas St. | Oklahoma | 25-OCT-08 | 501 | 64 | 7.83 | 0 | QB | JR |
| 23 | Graham Harrell, Texas Tech | Mississippi | 02-JAN-09 | 407 | 64 | 6.36 | 0 | QB | SR |
| 25 | Chris Turner, Maryland | Boston College | 29-NOV-08 | 329 | 63 | 5.22 | 1 | QB | JR |
| 26 | Chris Crane, Boston College | North Carolina St. | 04-OCT-08 | 470 | 62 | 7.58 | 3 | QB | SR |
| 26 | Todd Reesing, Kansas | Missouri | 29-NOV-08 | 392 | 62 | 6.32 | 0 | QB | JR |
| 26 | Austen Arnaud, Iowa St. | Kansas | 04-OCT-08 | 312 | 62 | 5.03 | 0 | QB | SO |
| 26 | Austin Davis, Southern Miss. | Auburn | 06-SEP-08 | 268 | 62 | 4.32 | 0 | QB | FR |
| 30 | Juice Williams, Illinois | Missouri | 30-AUG-08 | 461 | 61 | 7.56 | 0 | QB | JR |
| 30 | Austen Arnaud, Iowa St. | Missouri | 15-NOV-08 | 367 | 61 | 6.02 | 0 | QB | SO |
| 30 | Juice Williams, Illinois | Northwestern | 22-NOV-08 | 306 | 61 | 5.02 | 0 | QB | JR |
| 30 | Todd Reesing, Kansas | Florida Int'l | 30-AUG-08 | 271 | 61 | 4.44 | 0 | QB | JR |
| 30 | Ryan Lindley, San Diego St. | Notre Dame | 06-SEP-08 | 268 | 61 | 4.39 | 1 | QB | FR |
| 35 | Graham Harrell, Texas Tech | Eastern Wash. | 30-AUG-08 | 538 | 60 | 8.97 | 1 | QB | SR |
| 35 | Austen Arnaud, Iowa St. | Kansas St. | 22-NOV-08 | 493 | 60 | 8.22 | 0 | QB | SO |
| 35 | Matt Grothe, South Fla. | UCF | 06-SEP-08 | 400 | 60 | 6.67 | 0 | QB | JR |
| 35 | Todd Reesing, Kansas | South Fla. | 12-SEP-08 | 394 | 60 | 6.57 | 1 | QB | JR |
| 35 | Case Keenum, Houston | Colorado St. | 20-SEP-08 | 380 | 60 | 6.33 | 0 | QB | SO |
| 35 | Lyle Moevao, Oregon St. | Oregon | 29-NOV-08 | 368 | 60 | 6.13 | 0 | QB | JR |
| 35 | Arkelon Hall, Memphis | Marshall | 13-SEP-08 | 362 | 60 | 6.03 | 0 | QB | JR |
| 42 | Juice Williams, Illinois | Minnesota | 11-OCT-08 | 503 | 59 | 8.53 | 0 | QB | JR |
| 42 | Graham Harrell, Texas Tech | Texas A&M | 18-OCT-08 | 454 | 59 | 7.69 | 2 | QB | SR |
| 42 | Chase Daniel, Missouri | Oklahoma St. | 11-OCT-08 | 436 | 59 | 7.39 | 0 | QB | SR |
| 42 | Dan LeFevour, Central Mich. | Ohio | 13-SEP-08 | 406 | 59 | 6.88 | 1 | QB | JR |
| 42 | Chase Clement, Rice | Memphis | 06-SEP-08 | 398 | 59 | 6.75 | 2 | QB | SR |
| 42 | Jimmy Clausen, Notre Dame | North Carolina | 11-OCT-08 | 377 | 59 | 6.39 | 0 | QB | SO |
| 42 | Graham Harrell, Texas Tech | Oklahoma | 22-NOV-08 | 323 | 59 | 5.47 | 0 | QB | SR |
| 42 | Diondre Borel, Utah St. | Nevada | 18-OCT-08 | 312 | 59 | 5.29 | 0 | QB | SO |
| 42 | Austin Davis, Southern Miss. | UCF | 08-NOV-08 | 261 | 59 | 4.42 | 1 | QB | FR |
| 42 | Curtis Painter, Purdue | Oregon | 13-SEP-08 | 210 | 59 | 3.56 | 0 | QB | SR |
| 52 | Case Keenum, Houston | Rice | 29-NOV-08 | 513 | 58 | 8.84 | 0 | QB | SO |
| 52 | Jerrod Johnson, Texas A&M | Kansas St. | 11-OCT-08 | 487 | 58 | 8.4 | 1 | QB | SO |
| 52 | Case Keenum, Houston | UTEP | 22-NOV-08 | 475 | 58 | 8.19 | 2 | QB | SO |
| 52 | Lyle Moevao, Oregon St. | Stanford | 28-AUG-08 | 374 | 58 | 6.45 | 0 | QB | JR |
| 52 | Thaddeus Lewis, Duke | North Carolina St. | 08-NOV-08 | 358 | 58 | 6.17 | 0 | QB | JR |
| 52 | Austin Davis, Southern Miss. | Marshall | 20-SEP-08 | 353 | 58 | 6.09 | 1 | QB | FR |
| 52 | Kevin Craft, UCLA | Oregon | 11-OCT-08 | 299 | 58 | 5.16 | 0 | QB | JR |
| 52 | Giovanni Vizza, North Texas | Florida Int'l | 04-OCT-08 | 290 | 58 | 5 | 0 | QB | SO |
| 52 | Pat White, West Virginia | Cincinnati | 08-NOV-08 | 260 | 58 | 4.48 | 0 | QB | SR |
| 61 | Sam Bradford, Oklahoma | Kansas | 18-OCT-08 | 482 | 57 | 8.46 | 0 | QB | SO |
| 61 | Tim Hiller, Western Mich. | Central Mich. | 18-OCT-08 | 466 | 57 | 8.18 | 0 | QB | JR |
| 61 | Austen Arnaud, Iowa St. | Texas A&M | 25-OCT-08 | 438 | 57 | 7.68 | 1 | QB | SO |
| 61 | Juice Williams, Illinois | Western Mich. | 08-NOV-08 | 396 | 57 | 6.95 | 0 | QB | JR |
| 61 | Joe Ganz, Nebraska | Baylor | 25-OCT-08 | 378 | 57 | 6.63 | 0 | QB | SR |
| 61 | Chase Clement, Rice | Tulsa | 04-OCT-08 | 361 | 57 | 6.33 | 0 | QB | SR |
| 61 | Tim Hiller, Western Mich. | Nebraska | 30-AUG-08 | 313 | 57 | 5.49 | 0 | QB | JR |
| 61 | Giovanni Vizza, North Texas | Tulsa | 06-SEP-08 | 284 | 57 | 4.98 | 0 | QB | SO |
| 61 | Dominique Davis, Boston College | Virginia Tech | 06-DEC-08 | 275 | 57 | 4.82 | 0 | QB | FR |
| 70 | Graham Harrell, Texas Tech | Texas | 01-NOV-08 | 457 | 56 | 8.16 | 0 | QB | SR |
| 70 | Curtis Painter, Purdue | Indiana | 22-NOV-08 | 449 | 56 | 8.02 | 0 | QB | SR |
| 70 | Levi Brown, Troy | North Texas | 25-OCT-08 | 405 | 56 | 7.23 | 0 | QB | JR |
| 70 | Nate Davis, Ball St. | Buffalo | 05-DEC-08 | 387 | 56 | 6.91 | 0 | QB | JR |
| 70 | Colin Kaepernick, Nevada | Maryland | 30-DEC-08 | 385 | 56 | 6.88 | 1 | QB | SO |
| 70 | Chase Clement, Rice | Western Mich. | 30-DEC-08 | 379 | 56 | 6.77 | 2 | QB | SR |
| 70 | Matt Grothe, South Fla. | Kansas | 12-SEP-08 | 368 | 56 | 6.57 | 1 | QB | JR |
| 70 | Curtis Painter, Purdue | Notre Dame | 27-SEP-08 | 364 | 56 | 6.5 | 0 | QB | SR |
| 70 | Max Hall, BYU | Arizona | 20-DEC-08 | 344 | 56 | 6.14 | 1 | QB | JR |
| 70 | Matt Grothe, South Fla. | Rutgers | 15-NOV-08 | 342 | 56 | 6.11 | 0 | QB | JR |
| 70 | Ryan Lindley, San Diego St. | Wyoming | 01-NOV-08 | 293 | 56 | 5.23 | 0 | QB | FR |
| 70 | Greg Alexander, Hawaii | Cincinnati | 06-DEC-08 | 278 | 56 | 4.96 | 0 | QB | JR |
| 70 | Mike Kafka, Northwestern | Ohio St. | 08-NOV-08 | 260 | 56 | 4.64 | 1 | QB | JR |
| 70 | Jerrod Johnson, Texas A&M | Oklahoma St. | 04-OCT-08 | 260 | 56 | 4.64 | 0 | QB | SO |
| 70 | Giovanni Vizza, North Texas | Middle Tenn. St. | 22-NOV-08 | 250 | 56 | 4.46 | 0 | QB | SO |
| 70 | Curtis Painter, Purdue | Ohio St. | 11-OCT-08 | 228 | 56 | 4.07 | 0 | QB | SR |
| 70 | Todd Reesing, Kansas | Texas | 15-NOV-08 | 224 | 56 | 4 | 0 | QB | JR |
| 87 | Graham Harrell, Texas Tech | Oklahoma St. | 08-NOV-08 | 454 | 55 | 8.25 | 0 | QB | SR |
| 87 | Colt McCoy, Texas | Oklahoma St. | 25-OCT-08 | 432 | 55 | 7.85 | 1 | QB | JR |
| 87 | Colin Kaepernick, Nevada | Louisiana Tech | 29-NOV-08 | 425 | 55 | 7.73 | 0 | QB | SO |
| 87 | Julian Edelman, Kent St. | Bowling Green | 01-NOV-08 | 389 | 55 | 7.07 | 2 | QB | SR |
| 87 | Kinsmon Lancaster, La.-Monroe | Arkansas St. | 11-OCT-08 | 336 | 55 | 6.11 | 0 | QB | SR |
| 87 | Dan LeFevour, Central Mich. | Northern Ill. | 12-NOV-08 | 310 | 55 | 5.64 | 2 | QB | JR |
| 87 | Willie Tuitama, Arizona | New Mexico | 13-SEP-08 | 309 | 55 | 5.62 | 0 | QB | SR |
| 87 | Chase Holbrook, New Mexico St. | Idaho | 25-OCT-08 | 297 | 55 | 5.4 | 0 | QB | SR |
| 87 | Bill Stull, Pittsburgh | Bowling Green | 30-AUG-08 | 244 | 55 | 4.44 | 0 | QB | JR |
| 87 | Boo Jackson, Ohio | Northwestern | 20-SEP-08 | 200 | 55 | 3.64 | 0 | QB | JR |
| 97 | Chase Clement, Rice | Houston | 29-NOV-08 | 439 | 54 | 8.13 | 1 | QB | SR |
| 97 | Case Keenum, Houston | East Carolina | 27-SEP-08 | 424 | 54 | 7.85 | 0 | QB | SO |
| 97 | Chase Daniel, Missouri | Illinois | 30-AUG-08 | 369 | 54 | 6.83 | 0 | QB | SR |
| 97 | Todd Reesing, Kansas | Oklahoma | 18-OCT-08 | 351 | 54 | 6.5 | 0 | QB | JR |
| 97 | Chase Clement, Rice | Vanderbilt | 13-SEP-08 | 326 | 54 | 6.04 | 1 | QB | SR |
| 97 | Dan LeFevour, Central Mich. | Fla. Atlantic | 26-DEC-08 | 309 | 54 | 5.72 | 0 | QB | JR |
| 97 | Jamie Hampton, Troy | Oklahoma St. | 27-SEP-08 | 307 | 54 | 5.69 | 0 | QB | SO |
| 97 | Thaddeus Lewis, Duke | Northwestern | 06-SEP-08 | 294 | 54 | 5.44 | 1 | QB | JR |
| 97 | Thaddeus Lewis, Duke | North Carolina | 29-NOV-08 | 280 | 54 | 5.19 | 0 | QB | JR |
| 97 | Kevin Craft, UCLA | Stanford | 18-OCT-08 | 270 | 54 | 5 | 0 | QB | JR |
| 97 | Justin Roper, Oregon | Purdue | 13-SEP-08 | 238 | 54 | 4.41 | 0 | QB | SO |
| 97 | Bo Levi Mitchell, SMU | Southern Miss. | 29-NOV-08 | 219 | 54 | 4.06 | 0 | QB | FR |