| Rank | Player | Opponent | Sched Date | Yards | Plays | Average | TDR | Position | Class |
| 1 | Andy Schmitt, Eastern Mich. | Central Mich. | 28-NOV-08 | 554 | 89 | 6.22 | 1 | QB | JR |
| 2 | Graham Harrell, Texas Tech | Eastern Wash. | 30-AUG-08 | 538 | 60 | 8.97 | 1 | QB | SR |
| 3 | Case Keenum, Houston | Rice | 29-NOV-08 | 513 | 58 | 8.84 | 0 | QB | SO |
| 4 | Andy Schmitt, Eastern Mich. | Temple | 22-NOV-08 | 504 | 83 | 6.07 | 2 | QB | JR |
| 5 | Juice Williams, Illinois | Minnesota | 11-OCT-08 | 503 | 59 | 8.53 | 0 | QB | JR |
| 6 | Josh Freeman, Kansas St. | Oklahoma | 25-OCT-08 | 501 | 64 | 7.83 | 0 | QB | JR |
| 7 | Austen Arnaud, Iowa St. | Kansas St. | 22-NOV-08 | 493 | 60 | 8.22 | 0 | QB | SO |
| 8 | Max Hall, BYU | UNI | 30-AUG-08 | 490 | 44 | 11.14 | 1 | QB | JR |
| 9 | Jerrod Johnson, Texas A&M | Kansas St. | 11-OCT-08 | 487 | 58 | 8.4 | 1 | QB | SO |
| 10 | Sam Bradford, Oklahoma | Kansas | 18-OCT-08 | 482 | 57 | 8.46 | 0 | QB | SO |
| 11 | Case Keenum, Houston | UTEP | 22-NOV-08 | 475 | 58 | 8.19 | 2 | QB | SO |
| 12 | Chase Holbrook, New Mexico St. | Louisiana Tech | 22-NOV-08 | 472 | 67 | 7.04 | 0 | QB | SR |
| 13 | Chase Clement, Rice | Army | 08-NOV-08 | 471 | 37 | 12.73 | 1 | QB | SR |
| 14 | Chris Crane, Boston College | North Carolina St. | 04-OCT-08 | 470 | 62 | 7.58 | 3 | QB | SR |
| 15 | Case Keenum, Houston | Oklahoma St. | 06-SEP-08 | 468 | 70 | 6.69 | 0 | QB | SO |
| 16 | Tim Hiller, Western Mich. | Central Mich. | 18-OCT-08 | 466 | 57 | 8.18 | 0 | QB | JR |
| 16 | Chase Clement, Rice | Southern Miss. | 18-OCT-08 | 466 | 51 | 9.14 | 0 | QB | SR |
| 18 | David Johnson, Tulsa | New Mexico | 20-SEP-08 | 462 | 43 | 10.74 | 0 | QB | SR |
| 19 | Juice Williams, Illinois | Missouri | 30-AUG-08 | 461 | 61 | 7.56 | 0 | QB | JR |
| 19 | Zac Robinson, Oklahoma St. | Iowa St. | 01-NOV-08 | 461 | 33 | 13.97 | 0 | QB | JR |
| 21 | Brian Brunner, Central Mich. | Indiana | 01-NOV-08 | 460 | 65 | 7.08 | 1 | QB | SR |
| 22 | Ryan Lindley, San Diego St. | Idaho | 27-SEP-08 | 458 | 41 | 11.17 | 0 | QB | FR |
| 23 | Graham Harrell, Texas Tech | Texas | 01-NOV-08 | 457 | 56 | 8.16 | 0 | QB | SR |
| 24 | Graham Harrell, Texas Tech | Kansas St. | 04-OCT-08 | 455 | 52 | 8.75 | 1 | QB | SR |
| 24 | Chase Daniel, Missouri | Buffalo | 20-SEP-08 | 455 | 47 | 9.68 | 0 | QB | SR |
| 24 | David Johnson, Tulsa | UTEP | 18-OCT-08 | 455 | 34 | 13.38 | 0 | QB | SR |
| 27 | Graham Harrell, Texas Tech | Texas A&M | 18-OCT-08 | 454 | 59 | 7.69 | 2 | QB | SR |
| 27 | Graham Harrell, Texas Tech | Oklahoma St. | 08-NOV-08 | 454 | 55 | 8.25 | 0 | QB | SR |
| 29 | Curtis Painter, Purdue | Indiana | 22-NOV-08 | 449 | 56 | 8.02 | 0 | QB | SR |
| 30 | Mike Teel, Rutgers | Louisville | 04-DEC-08 | 447 | 26 | 17.19 | 0 | QB | SR |
| 31 | Austin Davis, Southern Miss. | Rice | 18-OCT-08 | 446 | 71 | 6.28 | 0 | QB | FR |
| 32 | Case Keenum, Houston | Tulsa | 15-NOV-08 | 445 | 41 | 10.85 | 1 | QB | SO |
| 33 | Chase Clement, Rice | Houston | 29-NOV-08 | 439 | 54 | 8.13 | 1 | QB | SR |
| 34 | Austen Arnaud, Iowa St. | Texas A&M | 25-OCT-08 | 438 | 57 | 7.68 | 1 | QB | SO |
| 35 | Case Keenum, Houston | Air Force | 13-SEP-08 | 437 | 67 | 6.52 | 0 | QB | SO |
| 36 | Chase Daniel, Missouri | Oklahoma St. | 11-OCT-08 | 436 | 59 | 7.39 | 0 | QB | SR |
| 37 | Colt McCoy, Texas | Oklahoma St. | 25-OCT-08 | 432 | 55 | 7.85 | 1 | QB | JR |
| 38 | Juice Williams, Illinois | Michigan | 04-OCT-08 | 431 | 45 | 9.58 | 2 | QB | JR |
| 39 | David Johnson, Tulsa | North Texas | 06-SEP-08 | 430 | 41 | 10.49 | 1 | QB | SR |
| 40 | Mark Sanchez, Southern California | Penn St. | 01-JAN-09 | 429 | 42 | 10.21 | 1 | QB | JR |
| 41 | Rudy Carpenter, Arizona St. | Northern Ariz. | 30-AUG-08 | 428 | 33 | 12.97 | 0 | QB | SR |
| 42 | Colin Kaepernick, Nevada | Louisiana Tech | 29-NOV-08 | 425 | 55 | 7.73 | 0 | QB | SO |
| 43 | Case Keenum, Houston | East Carolina | 27-SEP-08 | 424 | 54 | 7.85 | 0 | QB | SO |
| 44 | Dan LeFevour, Central Mich. | Ball St. | 19-NOV-08 | 420 | 68 | 6.18 | 0 | QB | JR |
| 45 | Chase Daniel, Missouri | Nevada | 13-SEP-08 | 417 | 29 | 14.38 | 0 | QB | SR |
| 46 | Colin Kaepernick, Nevada | UNLV | 27-SEP-08 | 416 | 34 | 12.24 | 3 | QB | SO |
| 47 | Todd Reesing, Kansas | Louisiana Tech | 06-SEP-08 | 415 | 42 | 9.88 | 0 | QB | JR |
| 48 | Boo Jackson, Ohio | Central Mich. | 13-SEP-08 | 413 | 40 | 10.33 | 0 | QB | JR |
| 49 | Case Keenum, Houston | SMU | 18-OCT-08 | 412 | 43 | 9.58 | 1 | QB | SO |
| 49 | Trevor Vittatoe, UTEP | SMU | 15-NOV-08 | 412 | 37 | 11.14 | 0 | QB | SO |
| 49 | Colt McCoy, Texas | Rice | 20-SEP-08 | 412 | 31 | 13.29 | 1 | QB | JR |
| 52 | Graham Harrell, Texas Tech | SMU | 13-SEP-08 | 411 | 51 | 8.06 | 0 | QB | SR |
| 53 | Kellen Moore, Boise St. | Nevada | 22-NOV-08 | 409 | 53 | 7.72 | 0 | QB | FR |
| 53 | Arkelon Hall, Memphis | Rice | 06-SEP-08 | 409 | 47 | 8.7 | 0 | QB | JR |
| 55 | Graham Harrell, Texas Tech | Mississippi | 02-JAN-09 | 407 | 64 | 6.36 | 0 | QB | SR |
| 56 | Dan LeFevour, Central Mich. | Ohio | 13-SEP-08 | 406 | 59 | 6.88 | 1 | QB | JR |
| 57 | Levi Brown, Troy | North Texas | 25-OCT-08 | 405 | 56 | 7.23 | 0 | QB | JR |
| 58 | Max Hall, BYU | Colorado St. | 01-NOV-08 | 404 | 41 | 9.85 | 0 | QB | JR |
| 59 | Dan LeFevour, Central Mich. | Purdue | 20-SEP-08 | 403 | 68 | 5.93 | 1 | QB | JR |
| 59 | Michael Desormeaux, La.-Lafayette | Kent St. | 20-SEP-08 | 403 | 39 | 10.33 | 1 | QB | SR |
| 61 | Kevin Riley, California | Maryland | 13-SEP-08 | 400 | 65 | 6.15 | 0 | QB | SO |
| 61 | Matt Grothe, South Fla. | UCF | 06-SEP-08 | 400 | 60 | 6.67 | 0 | QB | JR |
| 61 | Paul McCall, Florida Int'l | Fla. Atlantic | 29-NOV-08 | 400 | 53 | 7.55 | 0 | QB | JR |
| 61 | Graham Harrell, Texas Tech | Kansas | 25-OCT-08 | 400 | 49 | 8.16 | 1 | QB | SR |
| 65 | Colt McCoy, Texas | Ohio St. | 05-JAN-09 | 399 | 66 | 6.05 | 1 | QB | JR |
| 66 | Chase Clement, Rice | Memphis | 06-SEP-08 | 398 | 59 | 6.75 | 2 | QB | SR |
| 66 | Tim Hiller, Western Mich. | Ohio | 04-OCT-08 | 398 | 42 | 9.48 | 0 | QB | JR |
| 66 | Sam Bradford, Oklahoma | Cincinnati | 06-SEP-08 | 398 | 41 | 9.71 | 0 | QB | SO |
| 69 | Jerrod Johnson, Texas A&M | Iowa St. | 25-OCT-08 | 397 | 47 | 8.45 | 1 | QB | SO |
| 70 | Juice Williams, Illinois | Western Mich. | 08-NOV-08 | 396 | 57 | 6.95 | 0 | QB | JR |
| 71 | Jimmy Clausen, Notre Dame | Hawaii | 24-DEC-08 | 395 | 28 | 14.11 | 0 | QB | SO |
| 72 | Todd Reesing, Kansas | South Fla. | 12-SEP-08 | 394 | 60 | 6.57 | 1 | QB | JR |
| 73 | Chase Clement, Rice | UTEP | 01-NOV-08 | 393 | 53 | 7.42 | 1 | QB | SR |
| 73 | Matthew Stafford, Georgia | Georgia Tech | 29-NOV-08 | 393 | 43 | 9.14 | 0 | QB | JR |
| 75 | Joe Webb, UAB | Fla. Atlantic | 06-SEP-08 | 392 | 66 | 5.94 | 0 | QB | JR |
| 75 | Todd Reesing, Kansas | Missouri | 29-NOV-08 | 392 | 62 | 6.32 | 0 | QB | JR |
| 77 | Chase Daniel, Missouri | Kansas | 29-NOV-08 | 391 | 50 | 7.82 | 0 | QB | SR |
| 77 | Sam Bradford, Oklahoma | Missouri | 06-DEC-08 | 391 | 50 | 7.82 | 0 | QB | SO |
| 79 | Adam DiMichele, Temple | Eastern Mich. | 22-NOV-08 | 390 | 42 | 9.29 | 1 | QB | SR |
| 80 | Julian Edelman, Kent St. | Bowling Green | 01-NOV-08 | 389 | 55 | 7.07 | 2 | QB | SR |
| 80 | Dan LeFevour, Central Mich. | Eastern Mich. | 28-NOV-08 | 389 | 50 | 7.78 | 1 | QB | JR |
| 80 | Trevor Vittatoe, UTEP | Houston | 22-NOV-08 | 389 | 49 | 7.94 | 1 | QB | SO |
| 83 | Nate Davis, Ball St. | Buffalo | 05-DEC-08 | 387 | 56 | 6.91 | 0 | QB | JR |
| 83 | Pat White, West Virginia | North Carolina | 27-DEC-08 | 387 | 53 | 7.3 | 0 | QB | SR |
| 83 | Jeremiah Masoli, Oregon | Arizona | 15-NOV-08 | 387 | 36 | 10.75 | 3 | QB | SO |
| 86 | Sam Bradford, Oklahoma | Oklahoma St. | 29-NOV-08 | 386 | 48 | 8.04 | 1 | QB | SO |
| 87 | Colin Kaepernick, Nevada | Maryland | 30-DEC-08 | 385 | 56 | 6.88 | 1 | QB | SO |
| 87 | Chase Holbrook, New Mexico St. | Nevada | 11-OCT-08 | 385 | 52 | 7.4 | 1 | QB | SR |
| 89 | Ryan Lindley, San Diego St. | UNLV | 22-NOV-08 | 384 | 51 | 7.53 | 0 | QB | FR |
| 89 | Case Keenum, Houston | Southern U. | 30-AUG-08 | 384 | 46 | 8.35 | 0 | QB | SO |
| 91 | Zac Robinson, Oklahoma St. | Oregon | 30-DEC-08 | 383 | 66 | 5.8 | 1 | QB | JR |
| 91 | Case Keenum, Houston | Tulane | 08-NOV-08 | 383 | 43 | 8.91 | 0 | QB | SO |
| 91 | Joe Ganz, Nebraska | Western Mich. | 30-AUG-08 | 383 | 42 | 9.12 | 0 | QB | SR |
| 94 | Rusty Smith, Fla. Atlantic | Florida Int'l | 29-NOV-08 | 382 | 53 | 7.21 | 0 | QB | JR |
| 94 | Giovanni Vizza, North Texas | La.-Lafayette | 11-OCT-08 | 382 | 50 | 7.64 | 0 | QB | SO |
| 94 | Sam Bradford, Oklahoma | Texas | 11-OCT-08 | 382 | 47 | 8.13 | 0 | QB | SO |
| 97 | Adam Weber, Minnesota | Northwestern | 01-NOV-08 | 380 | 67 | 5.67 | 0 | QB | SO |
| 97 | Case Keenum, Houston | Colorado St. | 20-SEP-08 | 380 | 60 | 6.33 | 0 | QB | SO |
| 97 | Chase Holbrook, New Mexico St. | Hawaii | 08-NOV-08 | 380 | 47 | 8.09 | 0 | QB | SR |
| 97 | Sam Bradford, Oklahoma | TCU | 27-SEP-08 | 380 | 38 | 10 | 0 | QB | SO |