| Rank | Name | Opponent | Sched Date | Yards | Play | TD? |
| 1 | Southern Miss. | East Carolina | 15-NOV-08 | 97 | PASS DAVIS, Austin to BROWN, DeAndre | Y |
| 1 | Tulsa | UTEP | 18-OCT-08 | 97 | PASS JOHNSON,David to MARION,Brennan | Y |
| 3 | Oklahoma St. | Iowa St. | 01-NOV-08 | 95 | PASS Robinson, Zac to Broadway, J. | Y |
| 4 | SMU | UCF | 04-OCT-08 | 94 | PASS MITCHELL, B.L. to ROBINSON, A. | Y |
| 5 | Central Mich. | Eastern Mich. | 28-NOV-08 | 93 | PASS LeFEVOUR, Dan to BROWN, Antonio | N |
| 5 | Rutgers | South Fla. | 15-NOV-08 | 93 | PASS TEEL, Mike to BRITT, Kenny | Y |
| 7 | Texas | Texas Tech | 01-NOV-08 | 91 | PASS McCoy, Colt to Williams, Malco | Y |
| 7 | Northern Ill. | Minnesota | 30-AUG-08 | 91 | PASS HARNISH, Chand. to PALMER, Nathan | Y |
| 9 | Mississippi | La.-Monroe | 15-NOV-08 | 88 | PASS Snead,Jevan to Wallace,Mike | N |
| 9 | Georgia Tech | Duke | 04-OCT-08 | 88 | PASS Shaw, J. to Thomas, D. | Y |
| 9 | Marshall | Illinois St. | 30-AUG-08 | 88 | PASS CANN, Mark to PASSMORE, Dariu | Y |
| 12 | Arkansas | Mississippi St. | 22-NOV-08 | 87 | PASS Nathan Dick to Lucas Miller | Y |
| 13 | Troy | Florida Int'l | 18-OCT-08 | 86 | PASS Brown, L. to Jernigan, J. | Y |
| 13 | Mississippi | Florida | 27-SEP-08 | 86 | PASS Snead,Jevan to Hodge,Shay | Y |
| 15 | UTEP | SMU | 15-NOV-08 | 85 | PASS VITTATOE, T. to ADAMS, Kris | Y |
| 16 | Florida Int'l | Arkansas St. | 08-NOV-08 | 84 | PASS McCall, Paul to Hilton, T.Y. | N |
| 16 | New Mexico St. | Hawaii | 08-NOV-08 | 84 | PASS Holbrook, Chase to Williams, Chris | Y |
| 16 | Houston | East Carolina | 27-SEP-08 | 84 | PASS KEENUM, Case to JOHNSON, K. | Y |
| 16 | New Mexico St. | New Mexico | 27-SEP-08 | 84 | PASS Holbrook, Chase to Harris, A.J. | Y |
| 20 | Clemson | Duke | 15-NOV-08 | 83 | PASS Harper, C to Spiller, C | Y |
| 20 | New Mexico St. | Hawaii | 08-NOV-08 | 83 | PASS Holbrook, Chase to Williams, Chris | Y |
| 22 | Hawaii | Idaho | 22-NOV-08 | 82 | PASS Alexander,G. to Lane,M. | Y |
| 22 | La.-Lafayette | Florida Int'l | 01-NOV-08 | 82 | PASS Desormeaux, Mic to Falgout, Richie | N |
| 22 | Kent St. | Ohio | 11-OCT-08 | 82 | PASS EDELMAN, Julian to BAYES, Shawn | Y |
| 22 | Michigan St. | Indiana | 27-SEP-08 | 82 | PASS Hoyer, Brian to Gantt, Charlie | Y |
| 22 | Texas Tech | Nevada | 06-SEP-08 | 82 | PASS Harrell, Graham to Crabtree, M. | Y |
| 27 | Idaho | Boise St. | 15-NOV-08 | 81 | PASS Enderle, Nathan to Hardy, Daniel | Y |
| 27 | Kent St. | La.-Lafayette | 20-SEP-08 | 81 | PASS MAGAZU, Anthony to VANDERINK, Alan | Y |
| 27 | New Mexico | TCU | 30-AUG-08 | 81 | PASS GRUNER, Brad to HERNANDEZ, Chri | N |
| 30 | East Carolina | Kentucky | 02-JAN-09 | 80 | PASS PINKNEY, Pat to FREENEY, Darryl | Y |
| 30 | New Mexico St. | Louisiana Tech | 22-NOV-08 | 80 | PASS Holbrook, Chase to Williams, Chris | Y |
| 30 | Rice | Army | 08-NOV-08 | 80 | PASS CLEMENT, Chase to DILLARD, Jarett | Y |
| 30 | Oklahoma St. | Iowa St. | 01-NOV-08 | 80 | PASS Robinson, Zac to Bryant, Dez | Y |
| 30 | Penn St. | Michigan | 18-OCT-08 | 80 | PASS Devlin, Pat to Green, Stephfon | Y |
| 30 | New Mexico St. | Alcorn St. | 04-OCT-08 | 80 | PASS Holbrook, Chase to Williams, Chris | Y |
| 30 | Missouri | Nevada | 13-SEP-08 | 80 | PASS Daniel, Chase to Maclin, Jeremy | Y |
| 30 | Maryland | Middle Tenn. St. | 06-SEP-08 | 80 | PASS Turner to Heyward-Bey | Y |
| 30 | Boise St. | Idaho St. | 30-AUG-08 | 80 | PASS Kellen Moore to Titus Young | Y |
| 39 | Purdue | Indiana | 22-NOV-08 | 79 | PASS Painter,Curtis to Valentin,Aaron | Y |
| 39 | Central Mich. | Indiana | 01-NOV-08 | 79 | PASS BRUNNER, Brian to BROWN, Antonio | Y |
| 39 | Rutgers | Pittsburgh | 25-OCT-08 | 79 | PASS TEEL, Mike to BRITT, Kenny | Y |
| 39 | Vanderbilt | Duke | 25-OCT-08 | 79 | PASS Mackenzi Adams to Sean Walker | Y |
| 39 | Georgia Tech | Gardner-Webb | 11-OCT-08 | 79 | PASS Booker, C. to Dwyer, J. | Y |
| 39 | Indiana | Michigan St. | 27-SEP-08 | 79 | PASS Lewis, Kellen to Thigpen, Marcus | Y |
| 39 | New Mexico St. | New Mexico | 27-SEP-08 | 79 | PASS Holbrook, Chase to Anderson, M. | Y |
| 39 | Colorado St. | Houston | 20-SEP-08 | 79 | PASS FARRIS, Billy to MORTON, Dion | Y |
| 47 | Georgia | Kentucky | 08-NOV-08 | 78 | PASS M. Stafford to M. Massaquoi | N |
| 48 | Kansas St. | Oklahoma | 25-OCT-08 | 77 | PASS Freeman, Josh to Banks, Brandon | Y |
| 48 | SMU | Tulsa | 11-OCT-08 | 77 | PASS MITCHELL,B.L. to SANDERS,E. | Y |
| 48 | Illinois | Michigan | 04-OCT-08 | 77 | PASS Williams, Juice to Cumberland, J. | Y |
| 48 | Indiana | Minnesota | 04-OCT-08 | 77 | PASS Chappell, Ben to Thigpen, Marcus | Y |
| 48 | San Jose St. | Hawaii | 27-SEP-08 | 77 | PASS Reed,Kyle to Richmond,David | Y |
| 48 | Ohio | Central Mich. | 13-SEP-08 | 77 | PASS JACKSON, Boo to GARRETT, Chris | Y |
| 48 | Oklahoma | Washington | 13-SEP-08 | 77 | PASS Bradford, Sam to Broyles, Ryan | Y |
| 48 | Fresno St. | Rutgers | 01-SEP-08 | 77 | PASS Brandstater,T. to Ajirotutu,Seyi | N |