| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | Wyoming | 09/06/08 | 23-3 |
| Akron | Syracuse | 09/06/08 | 42-28 |
| Alabama | Tulane | 09/06/08 | 20-6 |
| Arizona | Toledo | 09/06/08 | 41-16 |
| Arizona St. | Stanford | 09/06/08 | 41-17 |
| Arkansas | La.-Monroe | 09/06/08 | 28-27 |
| Arkansas St. | Texas Southern | 09/06/08 | 83-10 |
| Army | New Hampshire | 09/06/08 | 10-28 |
| Auburn | Southern Miss. | 09/06/08 | 27-13 |
| Ball St. | Navy | 09/05/08 | 35-23 |
| Baylor | Northwestern St. | 09/06/08 | 51-6 |
| Boston College | Georgia Tech | 09/06/08 | 16-19 |
| Bowling Green | Minnesota | 09/06/08 | 17-42 |
| Buffalo | Pittsburgh | 09/06/08 | 16-27 |
| BYU | Washington | 09/06/08 | 28-27 |
| California | Washington St. | 09/06/08 | 66-3 |
| Central Mich. | Georgia | 09/06/08 | 17-56 |
| Cincinnati | Oklahoma | 09/06/08 | 26-52 |
| Clemson | Citadel | 09/06/08 | 45-17 |
| Colorado | Eastern Wash. | 09/06/08 | 31-24 |
| Colorado | Colorado St. | 08/31/08 | 38-17 |
| Colorado St. | Colorado | 08/31/08 | 17-38 |
| Colorado St. | Sacramento St. | 09/06/08 | 23-20 |
| Connecticut | Temple | 09/06/08 | 12-9 |
| Duke | Northwestern | 09/06/08 | 20-24 |
| East Carolina | West Virginia | 09/06/08 | 24-3 |
| Eastern Ky. | Western Ky. | 09/06/08 | 13-37 |
| Eastern Mich. | Michigan St. | 09/06/08 | 10-42 |
| Fla. Atlantic | UAB | 09/06/08 | 49-34 |
| Florida | Miami (Fla.) | 09/06/08 | 26-3 |
| Florida Int'l | Iowa | 09/06/08 | 0-42 |
| Florida St. | Western Caro. | 09/06/08 | 69-0 |
| Fresno St. | Rutgers | 09/01/08 | 24-7 |
| Georgia | Central Mich. | 09/06/08 | 56-17 |
| Georgia Tech | Boston College | 09/06/08 | 19-16 |
| Hawaii | Weber St. | 09/06/08 | 36-17 |
| Houston | Oklahoma St. | 09/06/08 | 37-56 |
| Idaho | Idaho St. | 09/06/08 | 42-27 |
| Illinois | Eastern Ill. | 09/06/08 | 47-21 |
| Indiana | Murray St. | 09/06/08 | 45-3 |
| Iowa | Florida Int'l | 09/06/08 | 42-0 |
| Iowa St. | Kent St. | 09/06/08 | 48-28 |
| Kansas | Louisiana Tech | 09/06/08 | 29-0 |
| Kansas St. | Montana St. | 09/06/08 | 69-10 |
| Kent St. | Iowa St. | 09/06/08 | 28-48 |
| Kentucky | Norfolk St. | 09/06/08 | 38-3 |
| Kentucky | Louisville | 08/31/08 | 27-2 |
| La.-Monroe | Arkansas | 09/06/08 | 27-28 |
| Louisiana Tech | Kansas | 09/06/08 | 0-29 |
| Louisville | Tennessee Tech | 09/06/08 | 51-10 |
| Louisville | Kentucky | 08/31/08 | 2-27 |
| Marshall | Wisconsin | 09/06/08 | 14-51 |
| Maryland | Middle Tenn. St. | 09/06/08 | 14-24 |
| Memphis | Rice | 09/06/08 | 35-42 |
| Miami (Fla.) | Florida | 09/06/08 | 3-26 |
| Miami (Ohio) | Michigan | 09/06/08 | 6-16 |
| Michigan | Miami (Ohio) | 09/06/08 | 16-6 |
| Michigan St. | Eastern Mich. | 09/06/08 | 42-10 |
| Middle Tenn. St. | Maryland | 09/06/08 | 24-14 |
| Minnesota | Bowling Green | 09/06/08 | 42-17 |
| Mississippi | Wake Forest | 09/06/08 | 28-30 |
| Mississippi St. | Southeastern La. | 09/06/08 | 34-10 |
| Missouri | Southeast Mo. St. | 09/06/08 | 52-3 |
| Navy | Ball St. | 09/05/08 | 23-35 |
| Nebraska | San Jose St. | 09/06/08 | 35-12 |
| Nevada | Texas Tech | 09/06/08 | 19-35 |
| New Mexico | Texas A&M | 09/06/08 | 22-28 |
| North Carolina St. | William & Mary | 09/06/08 | 34-24 |
| North Texas | Tulsa | 09/06/08 | 26-56 |
| Northern Ill. | Western Mich. | 09/06/08 | 26-29 |
| Northwestern | Duke | 09/06/08 | 24-20 |
| Notre Dame | San Diego St. | 09/06/08 | 21-13 |
| Ohio | Ohio St. | 09/06/08 | 14-26 |
| Ohio St. | Ohio | 09/06/08 | 26-14 |
| Oklahoma | Cincinnati | 09/06/08 | 52-26 |
| Oklahoma St. | Houston | 09/06/08 | 56-37 |
| Oregon | Utah St. | 09/06/08 | 66-24 |
| Oregon St. | Penn St. | 09/06/08 | 14-45 |
| Penn St. | Oregon St. | 09/06/08 | 45-14 |
| Pittsburgh | Buffalo | 09/06/08 | 27-16 |
| Purdue | Northern Colo. | 09/06/08 | 42-10 |
| Rice | Memphis | 09/06/08 | 42-35 |
| Rutgers | Fresno St. | 09/01/08 | 7-24 |
| San Diego St. | Notre Dame | 09/06/08 | 13-21 |
| San Jose St. | Nebraska | 09/06/08 | 12-35 |
| SMU | Texas St. | 09/06/08 | 47-36 |
| South Carolina | Vanderbilt | 09/04/08 | 17-24 |
| South Fla. | UCF | 09/06/08 | 31-24 |
| Southern Miss. | Auburn | 09/06/08 | 13-27 |
| Stanford | Arizona St. | 09/06/08 | 17-41 |
| Syracuse | Akron | 09/06/08 | 28-42 |
| TCU | Stephen F. Austin | 09/06/08 | 67-7 |
| Temple | Connecticut | 09/06/08 | 9-12 |
| Tennessee | UCLA | 09/01/08 | 24-27 |
| Texas | UTEP | 09/06/08 | 42-13 |
| Texas A&M | New Mexico | 09/06/08 | 28-22 |
| Texas Tech | Nevada | 09/06/08 | 35-19 |
| Toledo | Arizona | 09/06/08 | 16-41 |
| Tulane | Alabama | 09/06/08 | 6-20 |
| Tulsa | North Texas | 09/06/08 | 56-26 |
| UAB | Fla. Atlantic | 09/06/08 | 34-49 |
| UCF | South Fla. | 09/06/08 | 24-31 |
| UCLA | Tennessee | 09/01/08 | 27-24 |
| UNLV | Utah | 09/06/08 | 21-42 |
| Utah | UNLV | 09/06/08 | 42-21 |
| Utah St. | Oregon | 09/06/08 | 24-66 |
| UTEP | Texas | 09/06/08 | 13-42 |
| Vanderbilt | South Carolina | 09/04/08 | 24-17 |
| Virginia | Richmond | 09/06/08 | 16-0 |
| Virginia Tech | Furman | 09/06/08 | 24-7 |
| Wake Forest | Mississippi | 09/06/08 | 30-28 |
| Washington | BYU | 09/06/08 | 27-28 |
| Washington St. | California | 09/06/08 | 3-66 |
| West Virginia | East Carolina | 09/06/08 | 3-24 |
| Western Ky. | Eastern Ky. | 09/06/08 | 37-13 |
| Western Mich. | Northern Ill. | 09/06/08 | 29-26 |
| Wisconsin | Marshall | 09/06/08 | 51-14 |
| Wyoming | Air Force | 09/06/08 | 3-23 |