| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | Houston | 09/13/08 | 31-28 |
| Akron | Ball St. | 09/13/08 | 24-41 |
| Alabama | Western Ky. | 09/13/08 | 41-7 |
| Arizona | New Mexico | 09/13/08 | 28-36 |
| Arizona St. | UNLV | 09/13/08 | 20-23 |
| Arkansas St. | Southern Miss. | 09/13/08 | 24-27 |
| Auburn | Mississippi St. | 09/13/08 | 3-2 |
| Ball St. | Akron | 09/13/08 | 41-24 |
| Baylor | Washington St. | 09/12/08 | 45-17 |
| Boise St. | Bowling Green | 09/13/08 | 20-7 |
| Bowling Green | Boise St. | 09/13/08 | 7-20 |
| Buffalo | Temple | 09/13/08 | 30-28 |
| BYU | UCLA | 09/13/08 | 59-0 |
| California | Maryland | 09/13/08 | 27-35 |
| Central Mich. | Ohio | 09/13/08 | 31-28 |
| Clemson | North Carolina St. | 09/13/08 | 27-9 |
| Connecticut | Virginia | 09/13/08 | 45-10 |
| Duke | Navy | 09/13/08 | 41-31 |
| East Carolina | Tulane | 09/13/08 | 28-24 |
| Eastern Mich. | Toledo | 09/13/08 | 17-41 |
| Fla. Atlantic | Michigan St. | 09/13/08 | 0-17 |
| Florida St. | Chattanooga | 09/13/08 | 46-7 |
| Fresno St. | Wisconsin | 09/13/08 | 10-13 |
| Georgia | South Carolina | 09/13/08 | 14-7 |
| Georgia Tech | Virginia Tech | 09/13/08 | 17-20 |
| Hawaii | Oregon St. | 09/13/08 | 7-45 |
| Houston | Air Force | 09/13/08 | 28-31 |
| Idaho | Western Mich. | 09/13/08 | 28-51 |
| Illinois | La.-Lafayette | 09/13/08 | 20-17 |
| Iowa | Iowa St. | 09/13/08 | 17-5 |
| Iowa St. | Iowa | 09/13/08 | 5-17 |
| Kansas | South Fla. | 09/12/08 | 34-37 |
| Kent St. | Delaware St. | 09/13/08 | 24-3 |
| Kentucky | Middle Tenn. St. | 09/13/08 | 20-14 |
| La.-Lafayette | Illinois | 09/13/08 | 17-20 |
| La.-Monroe | Alabama A&M | 09/12/08 | 37-15 |
| LSU | North Texas | 09/13/08 | 41-3 |
| Marshall | Memphis | 09/13/08 | 17-16 |
| Maryland | California | 09/13/08 | 35-27 |
| Memphis | Marshall | 09/13/08 | 16-17 |
| Miami (Ohio) | Charleston So. | 09/13/08 | 38-27 |
| Michigan | Notre Dame | 09/13/08 | 17-35 |
| Michigan St. | Fla. Atlantic | 09/13/08 | 17-0 |
| Middle Tenn. St. | Kentucky | 09/13/08 | 14-20 |
| Minnesota | Montana St. | 09/13/08 | 35-23 |
| Mississippi | Samford | 09/13/08 | 34-10 |
| Mississippi St. | Auburn | 09/13/08 | 2-3 |
| Missouri | Nevada | 09/13/08 | 69-17 |
| Navy | Duke | 09/13/08 | 31-41 |
| Nebraska | New Mexico St. | 09/13/08 | 38-7 |
| Nevada | Missouri | 09/13/08 | 17-69 |
| New Mexico | Arizona | 09/13/08 | 36-28 |
| New Mexico St. | Nebraska | 09/13/08 | 7-38 |
| North Carolina | Rutgers | 09/11/08 | 44-12 |
| North Carolina St. | Clemson | 09/13/08 | 9-27 |
| North Texas | LSU | 09/13/08 | 3-41 |
| Northwestern | Southern Ill. | 09/13/08 | 33-7 |
| Notre Dame | Michigan | 09/13/08 | 35-17 |
| Ohio | Central Mich. | 09/13/08 | 28-31 |
| Ohio St. | Southern California | 09/13/08 | 3-35 |
| Oklahoma | Washington | 09/13/08 | 55-14 |
| Oklahoma St. | Missouri St. | 09/13/08 | 57-13 |
| Oregon | Purdue | 09/13/08 | 32-26 |
| Oregon St. | Hawaii | 09/13/08 | 45-7 |
| Penn St. | Syracuse | 09/13/08 | 55-13 |
| Purdue | Oregon | 09/13/08 | 26-32 |
| Rice | Vanderbilt | 09/13/08 | 21-38 |
| Rutgers | North Carolina | 09/11/08 | 12-44 |
| San Diego St. | San Jose St. | 09/13/08 | 10-35 |
| San Jose St. | San Diego St. | 09/13/08 | 35-10 |
| SMU | Texas Tech | 09/13/08 | 7-43 |
| South Carolina | Georgia | 09/13/08 | 7-14 |
| South Fla. | Kansas | 09/12/08 | 37-34 |
| Southern California | Ohio St. | 09/13/08 | 35-3 |
| Southern Miss. | Arkansas St. | 09/13/08 | 27-24 |
| Stanford | TCU | 09/13/08 | 14-31 |
| Syracuse | Penn St. | 09/13/08 | 13-55 |
| TCU | Stanford | 09/13/08 | 31-14 |
| Temple | Buffalo | 09/13/08 | 28-30 |
| Tennessee | UAB | 09/13/08 | 35-3 |
| Texas Tech | SMU | 09/13/08 | 43-7 |
| Toledo | Eastern Mich. | 09/13/08 | 41-17 |
| Troy | Alcorn St. | 09/13/08 | 65-0 |
| Tulane | East Carolina | 09/13/08 | 24-28 |
| UAB | Tennessee | 09/13/08 | 3-35 |
| UCLA | BYU | 09/13/08 | 0-59 |
| UNLV | Arizona St. | 09/13/08 | 23-20 |
| Utah | Utah St. | 09/13/08 | 58-10 |
| Utah St. | Utah | 09/13/08 | 10-58 |
| Vanderbilt | Rice | 09/13/08 | 38-21 |
| Virginia | Connecticut | 09/13/08 | 10-45 |
| Virginia Tech | Georgia Tech | 09/13/08 | 20-17 |
| Washington | Oklahoma | 09/13/08 | 14-55 |
| Washington St. | Baylor | 09/12/08 | 17-45 |
| Western Ky. | Alabama | 09/13/08 | 7-41 |
| Western Mich. | Idaho | 09/13/08 | 51-28 |
| Wisconsin | Fresno St. | 09/13/08 | 13-10 |
| Wyoming | North Dakota St. | 09/13/08 | 16-13 |