| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | Utah | 09/20/08 | 23-30 |
| Akron | Army | 09/20/08 | 22-3 |
| Alabama | Arkansas | 09/20/08 | 49-14 |
| Arizona | UCLA | 09/20/08 | 31-10 |
| Arizona St. | Georgia | 09/20/08 | 10-27 |
| Arkansas | Alabama | 09/20/08 | 14-49 |
| Arkansas St. | Middle Tenn. St. | 09/20/08 | 31-14 |
| Army | Akron | 09/20/08 | 3-22 |
| Auburn | LSU | 09/20/08 | 21-26 |
| Ball St. | Indiana | 09/20/08 | 42-20 |
| Baylor | Connecticut | 09/19/08 | 28-31 |
| Boise St. | Oregon | 09/20/08 | 37-32 |
| Boston College | UCF | 09/20/08 | 34-7 |
| Buffalo | Missouri | 09/20/08 | 21-42 |
| BYU | Wyoming | 09/20/08 | 44-0 |
| Central Mich. | Purdue | 09/20/08 | 25-32 |
| Cincinnati | Miami (Ohio) | 09/20/08 | 45-20 |
| Clemson | South Carolina St. | 09/20/08 | 54-0 |
| Colorado | West Virginia | 09/18/08 | 17-14 |
| Colorado St. | Houston | 09/20/08 | 28-25 |
| Connecticut | Baylor | 09/19/08 | 31-28 |
| East Carolina | North Carolina St. | 09/20/08 | 24-30 |
| Eastern Mich. | Maryland | 09/20/08 | 24-51 |
| Fla. Atlantic | Minnesota | 09/20/08 | 3-37 |
| Florida | Tennessee | 09/20/08 | 30-6 |
| Florida Int'l | South Fla. | 09/20/08 | 9-17 |
| Florida St. | Wake Forest | 09/20/08 | 3-12 |
| Fresno St. | Toledo | 09/20/08 | 55-54 |
| Georgia | Arizona St. | 09/20/08 | 27-10 |
| Georgia Tech | Mississippi St. | 09/20/08 | 38-7 |
| Houston | Colorado St. | 09/20/08 | 25-28 |
| Idaho | Utah St. | 09/20/08 | 17-42 |
| Indiana | Ball St. | 09/20/08 | 20-42 |
| Iowa | Pittsburgh | 09/20/08 | 20-21 |
| Iowa St. | UNLV | 09/20/08 | 31-34 |
| Kansas | Sam Houston St. | 09/20/08 | 38-14 |
| Kansas St. | Louisville | 09/17/08 | 29-38 |
| Kent St. | La.-Lafayette | 09/20/08 | 27-44 |
| La.-Lafayette | Kent St. | 09/20/08 | 44-27 |
| La.-Monroe | Tulane | 09/20/08 | 10-24 |
| Louisiana Tech | Southeastern La. | 09/20/08 | 41-26 |
| Louisville | Kansas St. | 09/17/08 | 38-29 |
| LSU | Auburn | 09/20/08 | 26-21 |
| Marshall | Southern Miss. | 09/20/08 | 34-27 |
| Maryland | Eastern Mich. | 09/20/08 | 51-24 |
| Memphis | Nicholls St. | 09/20/08 | 31-10 |
| Miami (Fla.) | Texas A&M | 09/20/08 | 41-23 |
| Miami (Ohio) | Cincinnati | 09/20/08 | 20-45 |
| Michigan St. | Notre Dame | 09/20/08 | 23-7 |
| Middle Tenn. St. | Arkansas St. | 09/20/08 | 14-31 |
| Minnesota | Fla. Atlantic | 09/20/08 | 37-3 |
| Mississippi | Vanderbilt | 09/20/08 | 17-23 |
| Mississippi St. | Georgia Tech | 09/20/08 | 7-38 |
| Missouri | Buffalo | 09/20/08 | 42-21 |
| Navy | Rutgers | 09/20/08 | 23-21 |
| New Mexico | Tulsa | 09/20/08 | 14-56 |
| New Mexico St. | UTEP | 09/20/08 | 34-33 |
| North Carolina | Virginia Tech | 09/20/08 | 17-20 |
| North Carolina St. | East Carolina | 09/20/08 | 30-24 |
| Northern Ill. | Indiana St. | 09/20/08 | 48-3 |
| Northwestern | Ohio | 09/20/08 | 16-8 |
| Notre Dame | Michigan St. | 09/20/08 | 7-23 |
| Ohio | Northwestern | 09/20/08 | 8-16 |
| Ohio St. | Troy | 09/20/08 | 28-10 |
| Oregon | Boise St. | 09/20/08 | 32-37 |
| Penn St. | Temple | 09/20/08 | 45-3 |
| Pittsburgh | Iowa | 09/20/08 | 21-20 |
| Purdue | Central Mich. | 09/20/08 | 32-25 |
| Rice | Texas | 09/20/08 | 10-52 |
| Rutgers | Navy | 09/20/08 | 21-23 |
| San Jose St. | Stanford | 09/20/08 | 10-23 |
| SMU | TCU | 09/20/08 | 7-48 |
| South Carolina | Wofford | 09/20/08 | 23-13 |
| South Fla. | Florida Int'l | 09/20/08 | 17-9 |
| Southern Miss. | Marshall | 09/20/08 | 27-34 |
| Stanford | San Jose St. | 09/20/08 | 23-10 |
| Syracuse | Northeastern | 09/20/08 | 30-21 |
| TCU | SMU | 09/20/08 | 48-7 |
| Temple | Penn St. | 09/20/08 | 3-45 |
| Tennessee | Florida | 09/20/08 | 6-30 |
| Texas | Rice | 09/20/08 | 52-10 |
| Texas A&M | Miami (Fla.) | 09/20/08 | 23-41 |
| Texas Tech | Massachusetts | 09/20/08 | 56-14 |
| Toledo | Fresno St. | 09/20/08 | 54-55 |
| Troy | Ohio St. | 09/20/08 | 10-28 |
| Tulane | La.-Monroe | 09/20/08 | 24-10 |
| Tulsa | New Mexico | 09/20/08 | 56-14 |
| UAB | Alabama St. | 09/20/08 | 45-10 |
| UCF | Boston College | 09/20/08 | 7-34 |
| UCLA | Arizona | 09/20/08 | 10-31 |
| UNLV | Iowa St. | 09/20/08 | 34-31 |
| Utah | Air Force | 09/20/08 | 30-23 |
| Utah St. | Idaho | 09/20/08 | 42-17 |
| UTEP | New Mexico St. | 09/20/08 | 33-34 |
| Vanderbilt | Mississippi | 09/20/08 | 23-17 |
| Virginia Tech | North Carolina | 09/20/08 | 20-17 |
| Wake Forest | Florida St. | 09/20/08 | 12-3 |
| Washington St. | Portland St. | 09/20/08 | 48-9 |
| West Virginia | Colorado | 09/18/08 | 14-17 |
| Western Ky. | Murray St. | 09/20/08 | 50-9 |
| Western Mich. | Tennessee Tech | 09/20/08 | 41-7 |
| Wyoming | BYU | 09/20/08 | 0-44 |