| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Akron | Cincinnati | 09/27/08 | 15-17 |
| Alabama | Georgia | 09/27/08 | 41-30 |
| Arkansas | Texas | 09/27/08 | 10-52 |
| Arkansas St. | Memphis | 09/27/08 | 17-29 |
| Army | Texas A&M | 09/27/08 | 17-21 |
| Auburn | Tennessee | 09/27/08 | 14-12 |
| Ball St. | Kent St. | 09/27/08 | 41-20 |
| Boston College | Rhode Island | 09/27/08 | 42-0 |
| Bowling Green | Wyoming | 09/27/08 | 45-16 |
| Buffalo | Central Mich. | 09/27/08 | 25-27 |
| California | Colorado St. | 09/27/08 | 42-7 |
| Central Mich. | Buffalo | 09/27/08 | 27-25 |
| Cincinnati | Akron | 09/27/08 | 17-15 |
| Clemson | Maryland | 09/27/08 | 17-20 |
| Colorado | Florida St. | 09/27/08 | 21-39 |
| Colorado St. | California | 09/27/08 | 7-42 |
| Connecticut | Louisville | 09/26/08 | 26-21 |
| Duke | Virginia | 09/27/08 | 31-3 |
| East Carolina | Houston | 09/27/08 | 24-41 |
| Eastern Mich. | Northern Ill. | 09/27/08 | 0-37 |
| Florida | Mississippi | 09/27/08 | 30-31 |
| Florida Int'l | Toledo | 09/27/08 | 35-16 |
| Florida St. | Colorado | 09/27/08 | 39-21 |
| Fresno St. | UCLA | 09/27/08 | 36-31 |
| Georgia | Alabama | 09/27/08 | 30-41 |
| Hawaii | San Jose St. | 09/27/08 | 17-20 |
| Houston | East Carolina | 09/27/08 | 41-24 |
| Idaho | San Diego St. | 09/27/08 | 17-45 |
| Illinois | Penn St. | 09/27/08 | 24-38 |
| Indiana | Michigan St. | 09/27/08 | 29-42 |
| Iowa | Northwestern | 09/27/08 | 17-22 |
| Kansas St. | La.-Lafayette | 09/27/08 | 45-37 |
| Kent St. | Ball St. | 09/27/08 | 20-41 |
| Kentucky | Western Ky. | 09/27/08 | 41-3 |
| La.-Lafayette | Kansas St. | 09/27/08 | 37-45 |
| Louisville | Connecticut | 09/26/08 | 21-26 |
| LSU | Mississippi St. | 09/27/08 | 34-24 |
| Marshall | West Virginia | 09/27/08 | 3-27 |
| Maryland | Clemson | 09/27/08 | 20-17 |
| Memphis | Arkansas St. | 09/27/08 | 29-17 |
| Miami (Fla.) | North Carolina | 09/27/08 | 24-28 |
| Michigan | Wisconsin | 09/27/08 | 27-25 |
| Michigan St. | Indiana | 09/27/08 | 42-29 |
| Minnesota | Ohio St. | 09/27/08 | 21-34 |
| Mississippi | Florida | 09/27/08 | 31-30 |
| Mississippi St. | LSU | 09/27/08 | 24-34 |
| Navy | Wake Forest | 09/27/08 | 24-17 |
| Nebraska | Virginia Tech | 09/27/08 | 30-35 |
| Nevada | UNLV | 09/27/08 | 49-27 |
| New Mexico | New Mexico St. | 09/27/08 | 35-24 |
| New Mexico St. | New Mexico | 09/27/08 | 24-35 |
| North Carolina | Miami (Fla.) | 09/27/08 | 28-24 |
| North Carolina St. | South Fla. | 09/27/08 | 10-41 |
| North Texas | Rice | 09/27/08 | 20-77 |
| Northern Ill. | Eastern Mich. | 09/27/08 | 37-0 |
| Northwestern | Iowa | 09/27/08 | 22-17 |
| Notre Dame | Purdue | 09/27/08 | 38-21 |
| Ohio | VMI | 09/27/08 | 51-31 |
| Ohio St. | Minnesota | 09/27/08 | 34-21 |
| Oklahoma | TCU | 09/27/08 | 35-10 |
| Oklahoma St. | Troy | 09/27/08 | 55-24 |
| Oregon | Washington St. | 09/27/08 | 63-14 |
| Oregon St. | Southern California | 09/25/08 | 27-21 |
| Penn St. | Illinois | 09/27/08 | 38-24 |
| Pittsburgh | Syracuse | 09/27/08 | 34-24 |
| Purdue | Notre Dame | 09/27/08 | 21-38 |
| Rice | North Texas | 09/27/08 | 77-20 |
| Rutgers | Morgan St. | 09/27/08 | 38-0 |
| San Diego St. | Idaho | 09/27/08 | 45-17 |
| San Jose St. | Hawaii | 09/27/08 | 20-17 |
| SMU | Tulane | 09/25/08 | 27-34 |
| South Carolina | UAB | 09/27/08 | 26-13 |
| South Fla. | North Carolina St. | 09/27/08 | 41-10 |
| Southern California | Oregon St. | 09/25/08 | 21-27 |
| Stanford | Washington | 09/27/08 | 35-28 |
| Syracuse | Pittsburgh | 09/27/08 | 24-34 |
| TCU | Oklahoma | 09/27/08 | 10-35 |
| Temple | Western Mich. | 09/27/08 | 3-7 |
| Tennessee | Auburn | 09/27/08 | 12-14 |
| Texas | Arkansas | 09/27/08 | 52-10 |
| Texas A&M | Army | 09/27/08 | 21-17 |
| Toledo | Florida Int'l | 09/27/08 | 16-35 |
| Troy | Oklahoma St. | 09/27/08 | 24-55 |
| Tulane | SMU | 09/25/08 | 34-27 |
| Tulsa | Central Ark. | 09/27/08 | 62-34 |
| UAB | South Carolina | 09/27/08 | 13-26 |
| UCF | UTEP | 09/27/08 | 13-58 |
| UCLA | Fresno St. | 09/27/08 | 31-36 |
| UNLV | Nevada | 09/27/08 | 27-49 |
| Utah | Weber St. | 09/27/08 | 37-21 |
| UTEP | UCF | 09/27/08 | 58-13 |
| Virginia | Duke | 09/27/08 | 3-31 |
| Virginia Tech | Nebraska | 09/27/08 | 35-30 |
| Wake Forest | Navy | 09/27/08 | 17-24 |
| Washington | Stanford | 09/27/08 | 28-35 |
| Washington St. | Oregon | 09/27/08 | 14-63 |
| West Virginia | Marshall | 09/27/08 | 27-3 |
| Western Ky. | Kentucky | 09/27/08 | 3-41 |
| Western Mich. | Temple | 09/27/08 | 7-3 |
| Wisconsin | Michigan | 09/27/08 | 25-27 |
| Wyoming | Bowling Green | 09/27/08 | 16-45 |