| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | Navy | 10/04/08 | 27-33 |
| Akron | Kent St. | 10/04/08 | 30-27 |
| Alabama | Kentucky | 10/04/08 | 17-14 |
| Arizona | Washington | 10/04/08 | 48-14 |
| Arizona St. | California | 10/04/08 | 14-24 |
| Arkansas | Florida | 10/04/08 | 7-38 |
| Army | Tulane | 10/04/08 | 44-13 |
| Auburn | Vanderbilt | 10/04/08 | 13-14 |
| Ball St. | Toledo | 10/04/08 | 31-0 |
| Baylor | Oklahoma | 10/04/08 | 17-49 |
| Boise St. | Louisiana Tech | 10/01/08 | 38-3 |
| Boston College | North Carolina St. | 10/04/08 | 38-31 |
| Bowling Green | Eastern Mich. | 10/04/08 | 21-24 |
| BYU | Utah St. | 10/03/08 | 34-14 |
| California | Arizona St. | 10/04/08 | 24-14 |
| Cincinnati | Marshall | 10/03/08 | 33-10 |
| Colorado | Texas | 10/04/08 | 14-38 |
| Colorado St. | UNLV | 10/04/08 | 41-28 |
| Connecticut | North Carolina | 10/04/08 | 12-38 |
| Duke | Georgia Tech | 10/04/08 | 0-27 |
| Eastern Mich. | Bowling Green | 10/04/08 | 24-21 |
| Fla. Atlantic | Middle Tenn. St. | 09/30/08 | 13-14 |
| Florida | Arkansas | 10/04/08 | 38-7 |
| Florida Int'l | North Texas | 10/04/08 | 42-10 |
| Florida St. | Miami (Fla.) | 10/04/08 | 41-39 |
| Fresno St. | Hawaii | 10/04/08 | 29-32 |
| Georgia Tech | Duke | 10/04/08 | 27-0 |
| Hawaii | Fresno St. | 10/04/08 | 32-29 |
| Idaho | Nevada | 10/04/08 | 14-49 |
| Illinois | Michigan | 10/04/08 | 45-20 |
| Indiana | Minnesota | 10/04/08 | 7-16 |
| Iowa | Michigan St. | 10/04/08 | 13-16 |
| Iowa St. | Kansas | 10/04/08 | 33-35 |
| Kansas | Iowa St. | 10/04/08 | 35-33 |
| Kansas St. | Texas Tech | 10/04/08 | 28-58 |
| Kent St. | Akron | 10/04/08 | 27-30 |
| Kentucky | Alabama | 10/04/08 | 14-17 |
| La.-Lafayette | La.-Monroe | 10/04/08 | 44-35 |
| La.-Monroe | La.-Lafayette | 10/04/08 | 35-44 |
| Louisiana Tech | Boise St. | 10/01/08 | 3-38 |
| Marshall | Cincinnati | 10/03/08 | 10-33 |
| Maryland | Virginia | 10/04/08 | 0-31 |
| Memphis | UAB | 10/02/08 | 33-30 |
| Miami (Fla.) | Florida St. | 10/04/08 | 39-41 |
| Miami (Ohio) | Temple | 10/04/08 | 10-28 |
| Michigan | Illinois | 10/04/08 | 20-45 |
| Michigan St. | Iowa | 10/04/08 | 16-13 |
| Middle Tenn. St. | Fla. Atlantic | 09/30/08 | 14-13 |
| Minnesota | Indiana | 10/04/08 | 16-7 |
| Mississippi | South Carolina | 10/04/08 | 24-31 |
| Missouri | Nebraska | 10/04/08 | 52-17 |
| Navy | Air Force | 10/04/08 | 33-27 |
| Nebraska | Missouri | 10/04/08 | 17-52 |
| Nevada | Idaho | 10/04/08 | 49-14 |
| New Mexico | Wyoming | 10/04/08 | 24-0 |
| New Mexico St. | Alcorn St. | 10/04/08 | 45-10 |
| North Carolina | Connecticut | 10/04/08 | 38-12 |
| North Carolina St. | Boston College | 10/04/08 | 31-38 |
| North Texas | Florida Int'l | 10/04/08 | 10-42 |
| Northern Ill. | Tennessee | 10/04/08 | 9-13 |
| Notre Dame | Stanford | 10/04/08 | 28-21 |
| Ohio | Western Mich. | 10/04/08 | 20-41 |
| Ohio St. | Wisconsin | 10/04/08 | 20-17 |
| Oklahoma | Baylor | 10/04/08 | 49-17 |
| Oklahoma St. | Texas A&M | 10/04/08 | 56-28 |
| Oregon | Southern California | 10/04/08 | 10-44 |
| Oregon St. | Utah | 10/02/08 | 28-31 |
| Penn St. | Purdue | 10/04/08 | 20-6 |
| Pittsburgh | South Fla. | 10/02/08 | 26-21 |
| Purdue | Penn St. | 10/04/08 | 6-20 |
| Rice | Tulsa | 10/04/08 | 28-63 |
| Rutgers | West Virginia | 10/04/08 | 17-24 |
| San Diego St. | TCU | 10/04/08 | 7-41 |
| SMU | UCF | 10/04/08 | 17-31 |
| South Carolina | Mississippi | 10/04/08 | 31-24 |
| South Fla. | Pittsburgh | 10/02/08 | 21-26 |
| Southern California | Oregon | 10/04/08 | 44-10 |
| Southern Miss. | UTEP | 10/04/08 | 37-40 |
| Stanford | Notre Dame | 10/04/08 | 21-28 |
| TCU | San Diego St. | 10/04/08 | 41-7 |
| Temple | Miami (Ohio) | 10/04/08 | 28-10 |
| Tennessee | Northern Ill. | 10/04/08 | 13-9 |
| Texas | Colorado | 10/04/08 | 38-14 |
| Texas A&M | Oklahoma St. | 10/04/08 | 28-56 |
| Texas Tech | Kansas St. | 10/04/08 | 58-28 |
| Toledo | Ball St. | 10/04/08 | 0-31 |
| Tulane | Army | 10/04/08 | 13-44 |
| Tulsa | Rice | 10/04/08 | 63-28 |
| UAB | Memphis | 10/02/08 | 30-33 |
| UCF | SMU | 10/04/08 | 31-17 |
| UCLA | Washington St. | 10/04/08 | 28-3 |
| UNLV | Colorado St. | 10/04/08 | 28-41 |
| Utah | Oregon St. | 10/02/08 | 31-28 |
| Utah St. | BYU | 10/03/08 | 14-34 |
| UTEP | Southern Miss. | 10/04/08 | 40-37 |
| Vanderbilt | Auburn | 10/04/08 | 14-13 |
| Virginia | Maryland | 10/04/08 | 31-0 |
| Virginia Tech | Western Ky. | 10/04/08 | 27-13 |
| Washington | Arizona | 10/04/08 | 14-48 |
| Washington St. | UCLA | 10/04/08 | 3-28 |
| West Virginia | Rutgers | 10/04/08 | 24-17 |
| Western Ky. | Virginia Tech | 10/04/08 | 13-27 |
| Western Mich. | Ohio | 10/04/08 | 41-20 |
| Wisconsin | Ohio St. | 10/04/08 | 17-20 |
| Wyoming | New Mexico | 10/04/08 | 0-24 |