| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | San Diego St. | 10/11/08 | 35-10 |
| Akron | Bowling Green | 10/11/08 | 33-37 |
| Arizona | Stanford | 10/11/08 | 23-24 |
| Arizona St. | Southern California | 10/11/08 | 0-28 |
| Arkansas | Auburn | 10/11/08 | 25-22 |
| Arkansas St. | La.-Monroe | 10/11/08 | 37-29 |
| Army | Eastern Mich. | 10/11/08 | 17-13 |
| Auburn | Arkansas | 10/11/08 | 22-25 |
| Ball St. | Western Ky. | 10/11/08 | 24-7 |
| Baylor | Iowa St. | 10/11/08 | 38-10 |
| Boise St. | Southern Miss. | 10/11/08 | 24-7 |
| Bowling Green | Akron | 10/11/08 | 37-33 |
| Buffalo | Western Mich. | 10/11/08 | 28-34 |
| BYU | New Mexico | 10/11/08 | 21-3 |
| Central Mich. | Temple | 10/11/08 | 24-14 |
| Cincinnati | Rutgers | 10/11/08 | 13-10 |
| Clemson | Wake Forest | 10/09/08 | 7-12 |
| Colorado | Kansas | 10/11/08 | 14-30 |
| Colorado St. | TCU | 10/11/08 | 7-13 |
| East Carolina | Virginia | 10/11/08 | 20-35 |
| Eastern Mich. | Army | 10/11/08 | 13-17 |
| Fla. Atlantic | Troy | 10/07/08 | 17-30 |
| Florida | LSU | 10/11/08 | 51-21 |
| Florida Int'l | Middle Tenn. St. | 10/11/08 | 31-21 |
| Fresno St. | Idaho | 10/11/08 | 45-32 |
| Georgia | Tennessee | 10/11/08 | 26-14 |
| Georgia Tech | Gardner-Webb | 10/11/08 | 10-7 |
| Hawaii | Louisiana Tech | 10/11/08 | 24-14 |
| Houston | UAB | 10/09/08 | 45-20 |
| Idaho | Fresno St. | 10/11/08 | 32-45 |
| Illinois | Minnesota | 10/11/08 | 20-27 |
| Indiana | Iowa | 10/11/08 | 9-45 |
| Iowa | Indiana | 10/11/08 | 45-9 |
| Iowa St. | Baylor | 10/11/08 | 10-38 |
| Kansas | Colorado | 10/11/08 | 30-14 |
| Kansas St. | Texas A&M | 10/11/08 | 44-30 |
| Kent St. | Ohio | 10/11/08 | 19-26 |
| Kentucky | South Carolina | 10/11/08 | 17-24 |
| La.-Lafayette | North Texas | 10/11/08 | 59-30 |
| La.-Monroe | Arkansas St. | 10/11/08 | 29-37 |
| Louisiana Tech | Hawaii | 10/11/08 | 14-24 |
| Louisville | Memphis | 10/10/08 | 35-28 |
| LSU | Florida | 10/11/08 | 21-51 |
| Memphis | Louisville | 10/10/08 | 28-35 |
| Miami (Fla.) | UCF | 10/11/08 | 20-14 |
| Miami (Ohio) | Northern Ill. | 10/11/08 | 13-17 |
| Michigan | Toledo | 10/11/08 | 10-13 |
| Michigan St. | Northwestern | 10/11/08 | 37-20 |
| Middle Tenn. St. | Florida Int'l | 10/11/08 | 21-31 |
| Minnesota | Illinois | 10/11/08 | 27-20 |
| Mississippi St. | Vanderbilt | 10/11/08 | 17-14 |
| Missouri | Oklahoma St. | 10/11/08 | 23-28 |
| Nebraska | Texas Tech | 10/11/08 | 31-37 |
| Nevada | New Mexico St. | 10/11/08 | 45-48 |
| New Mexico | BYU | 10/11/08 | 3-21 |
| New Mexico St. | Nevada | 10/11/08 | 48-45 |
| North Carolina | Notre Dame | 10/11/08 | 29-24 |
| North Texas | La.-Lafayette | 10/11/08 | 30-59 |
| Northern Ill. | Miami (Ohio) | 10/11/08 | 17-13 |
| Northwestern | Michigan St. | 10/11/08 | 20-37 |
| Notre Dame | North Carolina | 10/11/08 | 24-29 |
| Ohio | Kent St. | 10/11/08 | 26-19 |
| Ohio St. | Purdue | 10/11/08 | 16-3 |
| Oklahoma | Texas | 10/11/08 | 35-45 |
| Oklahoma St. | Missouri | 10/11/08 | 28-23 |
| Oregon | UCLA | 10/11/08 | 31-24 |
| Oregon St. | Washington St. | 10/11/08 | 66-13 |
| Penn St. | Wisconsin | 10/11/08 | 48-7 |
| Purdue | Ohio St. | 10/11/08 | 3-16 |
| Rutgers | Cincinnati | 10/11/08 | 10-13 |
| San Diego St. | Air Force | 10/11/08 | 10-35 |
| San Jose St. | Utah St. | 10/11/08 | 30-7 |
| SMU | Tulsa | 10/11/08 | 31-37 |
| South Carolina | Kentucky | 10/11/08 | 24-17 |
| Southern California | Arizona St. | 10/11/08 | 28-0 |
| Southern Miss. | Boise St. | 10/11/08 | 7-24 |
| Stanford | Arizona | 10/11/08 | 24-23 |
| Syracuse | West Virginia | 10/11/08 | 6-17 |
| TCU | Colorado St. | 10/11/08 | 13-7 |
| Temple | Central Mich. | 10/11/08 | 14-24 |
| Tennessee | Georgia | 10/11/08 | 14-26 |
| Texas | Oklahoma | 10/11/08 | 45-35 |
| Texas A&M | Kansas St. | 10/11/08 | 30-44 |
| Texas Tech | Nebraska | 10/11/08 | 37-31 |
| Toledo | Michigan | 10/11/08 | 13-10 |
| Troy | Fla. Atlantic | 10/07/08 | 30-17 |
| Tulane | UTEP | 10/11/08 | 21-24 |
| Tulsa | SMU | 10/11/08 | 37-31 |
| UAB | Houston | 10/09/08 | 20-45 |
| UCF | Miami (Fla.) | 10/11/08 | 14-20 |
| UCLA | Oregon | 10/11/08 | 24-31 |
| Utah | Wyoming | 10/11/08 | 40-7 |
| Utah St. | San Jose St. | 10/11/08 | 7-30 |
| UTEP | Tulane | 10/11/08 | 24-21 |
| Vanderbilt | Mississippi St. | 10/11/08 | 14-17 |
| Virginia | East Carolina | 10/11/08 | 35-20 |
| Wake Forest | Clemson | 10/09/08 | 12-7 |
| Washington St. | Oregon St. | 10/11/08 | 13-66 |
| West Virginia | Syracuse | 10/11/08 | 17-6 |
| Western Ky. | Ball St. | 10/11/08 | 7-24 |
| Western Mich. | Buffalo | 10/11/08 | 34-28 |
| Wisconsin | Penn St. | 10/11/08 | 7-48 |
| Wyoming | Utah | 10/11/08 | 7-40 |