| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | UNLV | 10/18/08 | 29-28 |
| Akron | Eastern Mich. | 10/18/08 | 42-35 |
| Alabama | Mississippi | 10/18/08 | 24-20 |
| Arizona | California | 10/18/08 | 42-27 |
| Arkansas | Kentucky | 10/18/08 | 20-21 |
| Arkansas St. | La.-Lafayette | 10/18/08 | 23-28 |
| Army | Buffalo | 10/18/08 | 24-27 |
| Baylor | Oklahoma St. | 10/18/08 | 6-34 |
| Boise St. | Hawaii | 10/17/08 | 27-7 |
| Boston College | Virginia Tech | 10/18/08 | 28-23 |
| Bowling Green | Miami (Ohio) | 10/18/08 | 20-27 |
| Buffalo | Army | 10/18/08 | 27-24 |
| BYU | TCU | 10/16/08 | 7-32 |
| California | Arizona | 10/18/08 | 27-42 |
| Central Mich. | Western Mich. | 10/18/08 | 38-28 |
| Clemson | Georgia Tech | 10/18/08 | 17-21 |
| Colorado | Kansas St. | 10/18/08 | 14-13 |
| Colorado St. | Utah | 10/18/08 | 16-49 |
| Connecticut | Rutgers | 10/18/08 | 10-12 |
| Duke | Miami (Fla.) | 10/18/08 | 31-49 |
| East Carolina | Memphis | 10/18/08 | 30-10 |
| Eastern Mich. | Akron | 10/18/08 | 35-42 |
| Fla. Atlantic | Western Ky. | 10/18/08 | 24-20 |
| Florida Int'l | Troy | 10/18/08 | 23-33 |
| Florida St. | North Carolina St. | 10/16/08 | 26-17 |
| Georgia | Vanderbilt | 10/18/08 | 24-14 |
| Georgia Tech | Clemson | 10/18/08 | 21-17 |
| Hawaii | Boise St. | 10/17/08 | 7-27 |
| Houston | SMU | 10/18/08 | 44-38 |
| Idaho | Louisiana Tech | 10/18/08 | 14-46 |
| Illinois | Indiana | 10/18/08 | 55-13 |
| Indiana | Illinois | 10/18/08 | 13-55 |
| Iowa | Wisconsin | 10/18/08 | 38-16 |
| Iowa St. | Nebraska | 10/18/08 | 7-35 |
| Kansas | Oklahoma | 10/18/08 | 31-45 |
| Kansas St. | Colorado | 10/18/08 | 13-14 |
| Kentucky | Arkansas | 10/18/08 | 21-20 |
| La.-Lafayette | Arkansas St. | 10/18/08 | 28-23 |
| La.-Monroe | North Texas | 10/18/08 | 35-23 |
| Louisiana Tech | Idaho | 10/18/08 | 46-14 |
| Louisville | Middle Tenn. St. | 10/18/08 | 42-23 |
| LSU | South Carolina | 10/18/08 | 24-17 |
| Marshall | UAB | 10/18/08 | 21-23 |
| Maryland | Wake Forest | 10/18/08 | 26-0 |
| Memphis | East Carolina | 10/18/08 | 10-30 |
| Miami (Fla.) | Duke | 10/18/08 | 49-31 |
| Miami (Ohio) | Bowling Green | 10/18/08 | 27-20 |
| Michigan | Penn St. | 10/18/08 | 17-46 |
| Michigan St. | Ohio St. | 10/18/08 | 7-45 |
| Middle Tenn. St. | Louisville | 10/18/08 | 23-42 |
| Mississippi | Alabama | 10/18/08 | 20-24 |
| Mississippi St. | Tennessee | 10/18/08 | 3-34 |
| Missouri | Texas | 10/18/08 | 31-56 |
| Navy | Pittsburgh | 10/18/08 | 21-42 |
| Nebraska | Iowa St. | 10/18/08 | 35-7 |
| Nevada | Utah St. | 10/18/08 | 44-17 |
| New Mexico | San Diego St. | 10/18/08 | 70-7 |
| New Mexico St. | San Jose St. | 10/18/08 | 14-31 |
| North Carolina | Virginia | 10/18/08 | 13-16 |
| North Carolina St. | Florida St. | 10/16/08 | 17-26 |
| North Texas | La.-Monroe | 10/18/08 | 23-35 |
| Northern Ill. | Toledo | 10/18/08 | 38-7 |
| Northwestern | Purdue | 10/18/08 | 48-26 |
| Ohio St. | Michigan St. | 10/18/08 | 45-7 |
| Oklahoma | Kansas | 10/18/08 | 45-31 |
| Oklahoma St. | Baylor | 10/18/08 | 34-6 |
| Oregon St. | Washington | 10/18/08 | 34-13 |
| Penn St. | Michigan | 10/18/08 | 46-17 |
| Pittsburgh | Navy | 10/18/08 | 42-21 |
| Purdue | Northwestern | 10/18/08 | 26-48 |
| Rice | Southern Miss. | 10/18/08 | 45-40 |
| Rutgers | Connecticut | 10/18/08 | 12-10 |
| San Diego St. | New Mexico | 10/18/08 | 7-70 |
| San Jose St. | New Mexico St. | 10/18/08 | 31-14 |
| SMU | Houston | 10/18/08 | 38-44 |
| South Carolina | LSU | 10/18/08 | 17-24 |
| South Fla. | Syracuse | 10/18/08 | 45-13 |
| Southern California | Washington St. | 10/18/08 | 69-0 |
| Southern Miss. | Rice | 10/18/08 | 40-45 |
| Stanford | UCLA | 10/18/08 | 20-23 |
| Syracuse | South Fla. | 10/18/08 | 13-45 |
| TCU | BYU | 10/16/08 | 32-7 |
| Tennessee | Mississippi St. | 10/18/08 | 34-3 |
| Texas | Missouri | 10/18/08 | 56-31 |
| Texas A&M | Texas Tech | 10/18/08 | 25-43 |
| Texas Tech | Texas A&M | 10/18/08 | 43-25 |
| Toledo | Northern Ill. | 10/18/08 | 7-38 |
| Troy | Florida Int'l | 10/18/08 | 33-23 |
| Tulsa | UTEP | 10/18/08 | 77-35 |
| UAB | Marshall | 10/18/08 | 23-21 |
| UCLA | Stanford | 10/18/08 | 23-20 |
| UNLV | Air Force | 10/18/08 | 28-29 |
| Utah | Colorado St. | 10/18/08 | 49-16 |
| Utah St. | Nevada | 10/18/08 | 17-44 |
| UTEP | Tulsa | 10/18/08 | 35-77 |
| Vanderbilt | Georgia | 10/18/08 | 14-24 |
| Virginia | North Carolina | 10/18/08 | 16-13 |
| Virginia Tech | Boston College | 10/18/08 | 23-28 |
| Wake Forest | Maryland | 10/18/08 | 0-26 |
| Washington | Oregon St. | 10/18/08 | 13-34 |
| Washington St. | Southern California | 10/18/08 | 0-69 |
| Western Ky. | Fla. Atlantic | 10/18/08 | 20-24 |
| Western Mich. | Central Mich. | 10/18/08 | 28-38 |
| Wisconsin | Iowa | 10/18/08 | 16-38 |