| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | New Mexico | 10/23/08 | 23-10 |
| Alabama | Tennessee | 10/25/08 | 29-9 |
| Arizona | Southern California | 10/25/08 | 10-17 |
| Arizona St. | Oregon | 10/25/08 | 20-54 |
| Arkansas | Mississippi | 10/25/08 | 21-23 |
| Army | Louisiana Tech | 10/25/08 | 14-7 |
| Auburn | West Virginia | 10/23/08 | 17-34 |
| Ball St. | Eastern Mich. | 10/25/08 | 38-16 |
| Baylor | Nebraska | 10/25/08 | 20-32 |
| Boise St. | San Jose St. | 10/24/08 | 33-16 |
| Boston College | North Carolina | 10/25/08 | 24-45 |
| Bowling Green | Northern Ill. | 10/25/08 | 13-16 |
| BYU | UNLV | 10/25/08 | 42-35 |
| California | UCLA | 10/25/08 | 41-20 |
| Central Mich. | Toledo | 10/25/08 | 24-23 |
| Cincinnati | Connecticut | 10/25/08 | 16-40 |
| Colorado | Missouri | 10/25/08 | 0-58 |
| Colorado St. | San Diego St. | 10/25/08 | 38-34 |
| Connecticut | Cincinnati | 10/25/08 | 40-16 |
| Duke | Vanderbilt | 10/25/08 | 10-7 |
| Eastern Mich. | Ball St. | 10/25/08 | 16-38 |
| Fla. Atlantic | La.-Monroe | 10/25/08 | 29-28 |
| Florida | Kentucky | 10/25/08 | 63-5 |
| Florida St. | Virginia Tech | 10/25/08 | 30-20 |
| Fresno St. | Utah St. | 10/25/08 | 30-28 |
| Georgia | LSU | 10/25/08 | 52-38 |
| Georgia Tech | Virginia | 10/25/08 | 17-24 |
| Hawaii | Nevada | 10/25/08 | 38-31 |
| Idaho | New Mexico St. | 10/25/08 | 20-14 |
| Illinois | Wisconsin | 10/25/08 | 17-27 |
| Indiana | Northwestern | 10/25/08 | 21-19 |
| Iowa St. | Texas A&M | 10/25/08 | 35-49 |
| Kansas | Texas Tech | 10/25/08 | 21-63 |
| Kansas St. | Oklahoma | 10/25/08 | 35-58 |
| Kent St. | Miami (Ohio) | 10/25/08 | 54-21 |
| Kentucky | Florida | 10/25/08 | 5-63 |
| La.-Monroe | Fla. Atlantic | 10/25/08 | 28-29 |
| Louisiana Tech | Army | 10/25/08 | 7-14 |
| Louisville | South Fla. | 10/25/08 | 24-20 |
| LSU | Georgia | 10/25/08 | 38-52 |
| Maryland | North Carolina St. | 10/25/08 | 27-24 |
| Memphis | Southern Miss. | 10/25/08 | 36-30 |
| Miami (Fla.) | Wake Forest | 10/25/08 | 16-10 |
| Miami (Ohio) | Kent St. | 10/25/08 | 21-54 |
| Michigan | Michigan St. | 10/25/08 | 21-35 |
| Michigan St. | Michigan | 10/25/08 | 35-21 |
| Middle Tenn. St. | Mississippi St. | 10/25/08 | 22-31 |
| Minnesota | Purdue | 10/25/08 | 17-6 |
| Mississippi | Arkansas | 10/25/08 | 23-21 |
| Mississippi St. | Middle Tenn. St. | 10/25/08 | 31-22 |
| Missouri | Colorado | 10/25/08 | 58-0 |
| Navy | SMU | 10/25/08 | 34-7 |
| Nebraska | Baylor | 10/25/08 | 32-20 |
| Nevada | Hawaii | 10/25/08 | 31-38 |
| New Mexico | Air Force | 10/23/08 | 10-23 |
| New Mexico St. | Idaho | 10/25/08 | 14-20 |
| North Carolina | Boston College | 10/25/08 | 45-24 |
| North Carolina St. | Maryland | 10/25/08 | 24-27 |
| North Texas | Troy | 10/25/08 | 17-45 |
| Northern Ill. | Bowling Green | 10/25/08 | 16-13 |
| Northwestern | Indiana | 10/25/08 | 19-21 |
| Notre Dame | Washington | 10/25/08 | 33-7 |
| Ohio | Temple | 10/21/08 | 10-14 |
| Ohio St. | Penn St. | 10/25/08 | 6-13 |
| Oklahoma | Kansas St. | 10/25/08 | 58-35 |
| Oklahoma St. | Texas | 10/25/08 | 24-28 |
| Oregon | Arizona St. | 10/25/08 | 54-20 |
| Penn St. | Ohio St. | 10/25/08 | 13-6 |
| Pittsburgh | Rutgers | 10/25/08 | 34-54 |
| Purdue | Minnesota | 10/25/08 | 6-17 |
| Rice | Tulane | 10/25/08 | 42-17 |
| Rutgers | Pittsburgh | 10/25/08 | 54-34 |
| San Diego St. | Colorado St. | 10/25/08 | 34-38 |
| San Jose St. | Boise St. | 10/24/08 | 16-33 |
| SMU | Navy | 10/25/08 | 7-34 |
| South Fla. | Louisville | 10/25/08 | 20-24 |
| Southern California | Arizona | 10/25/08 | 17-10 |
| Southern Miss. | Memphis | 10/25/08 | 30-36 |
| TCU | Wyoming | 10/25/08 | 54-7 |
| Temple | Ohio | 10/21/08 | 14-10 |
| Tennessee | Alabama | 10/25/08 | 9-29 |
| Texas | Oklahoma St. | 10/25/08 | 28-24 |
| Texas A&M | Iowa St. | 10/25/08 | 49-35 |
| Texas Tech | Kansas | 10/25/08 | 63-21 |
| Toledo | Central Mich. | 10/25/08 | 23-24 |
| Troy | North Texas | 10/25/08 | 45-17 |
| Tulane | Rice | 10/25/08 | 17-42 |
| UCLA | California | 10/25/08 | 20-41 |
| UNLV | BYU | 10/25/08 | 35-42 |
| Utah St. | Fresno St. | 10/25/08 | 28-30 |
| Vanderbilt | Duke | 10/25/08 | 7-10 |
| Virginia | Georgia Tech | 10/25/08 | 24-17 |
| Virginia Tech | Florida St. | 10/25/08 | 20-30 |
| Wake Forest | Miami (Fla.) | 10/25/08 | 10-16 |
| Washington | Notre Dame | 10/25/08 | 7-33 |
| West Virginia | Auburn | 10/23/08 | 34-17 |
| Wisconsin | Illinois | 10/25/08 | 27-17 |
| Wyoming | TCU | 10/25/08 | 7-54 |