| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | BYU | 11/15/08 | 24-38 |
| Akron | Buffalo | 11/13/08 | 40-43 |
| Alabama | Mississippi St. | 11/15/08 | 32-7 |
| Arizona | Oregon | 11/15/08 | 45-55 |
| Arizona St. | Washington St. | 11/15/08 | 31-0 |
| Auburn | Georgia | 11/15/08 | 13-17 |
| Ball St. | Miami (Ohio) | 11/11/08 | 31-16 |
| Baylor | Texas A&M | 11/15/08 | 41-21 |
| Boise St. | Idaho | 11/15/08 | 45-10 |
| Boston College | Florida St. | 11/15/08 | 27-17 |
| Buffalo | Akron | 11/13/08 | 43-40 |
| BYU | Air Force | 11/15/08 | 38-24 |
| California | Oregon St. | 11/15/08 | 21-34 |
| Central Mich. | Northern Ill. | 11/12/08 | 33-30 |
| Cincinnati | Louisville | 11/14/08 | 28-20 |
| Clemson | Duke | 11/15/08 | 31-7 |
| Colorado | Oklahoma St. | 11/15/08 | 17-30 |
| Colorado St. | New Mexico | 11/15/08 | 20-6 |
| Connecticut | Syracuse | 11/15/08 | 39-14 |
| Duke | Clemson | 11/15/08 | 7-31 |
| East Carolina | Southern Miss. | 11/15/08 | 3-21 |
| Fla. Atlantic | La.-Lafayette | 11/15/08 | 40-29 |
| Florida | South Carolina | 11/15/08 | 56-6 |
| Florida St. | Boston College | 11/15/08 | 17-27 |
| Fresno St. | New Mexico St. | 11/15/08 | 24-17 |
| Georgia | Auburn | 11/15/08 | 17-13 |
| Houston | Tulsa | 11/15/08 | 70-30 |
| Idaho | Boise St. | 11/15/08 | 10-45 |
| Illinois | Ohio St. | 11/15/08 | 20-30 |
| Indiana | Penn St. | 11/15/08 | 7-34 |
| Iowa | Purdue | 11/15/08 | 22-17 |
| Iowa St. | Missouri | 11/15/08 | 20-52 |
| Kansas | Texas | 11/15/08 | 7-35 |
| Kansas St. | Nebraska | 11/15/08 | 28-56 |
| Kent St. | Temple | 11/12/08 | 41-38 |
| Kentucky | Vanderbilt | 11/15/08 | 24-31 |
| La.-Lafayette | Fla. Atlantic | 11/15/08 | 29-40 |
| La.-Monroe | Mississippi | 11/15/08 | 0-59 |
| Louisiana Tech | Utah St. | 11/15/08 | 45-38 |
| Louisville | Cincinnati | 11/14/08 | 20-28 |
| LSU | Troy | 11/15/08 | 40-31 |
| Marshall | UCF | 11/15/08 | 14-30 |
| Maryland | North Carolina | 11/15/08 | 17-15 |
| Miami (Fla.) | Virginia Tech | 11/13/08 | 16-14 |
| Miami (Ohio) | Ball St. | 11/11/08 | 16-31 |
| Michigan | Northwestern | 11/15/08 | 14-21 |
| Middle Tenn. St. | Western Ky. | 11/15/08 | 21-10 |
| Minnesota | Wisconsin | 11/15/08 | 32-35 |
| Mississippi | La.-Monroe | 11/15/08 | 59-0 |
| Mississippi St. | Alabama | 11/15/08 | 7-32 |
| Missouri | Iowa St. | 11/15/08 | 52-20 |
| Navy | Notre Dame | 11/15/08 | 21-27 |
| Nebraska | Kansas St. | 11/15/08 | 56-28 |
| Nevada | San Jose St. | 11/15/08 | 41-17 |
| New Mexico | Colorado St. | 11/15/08 | 6-20 |
| New Mexico St. | Fresno St. | 11/15/08 | 17-24 |
| North Carolina | Maryland | 11/15/08 | 15-17 |
| North Carolina St. | Wake Forest | 11/15/08 | 21-17 |
| Northern Ill. | Central Mich. | 11/12/08 | 30-33 |
| Northwestern | Michigan | 11/15/08 | 21-14 |
| Notre Dame | Navy | 11/15/08 | 27-21 |
| Ohio St. | Illinois | 11/15/08 | 30-20 |
| Oklahoma St. | Colorado | 11/15/08 | 30-17 |
| Oregon | Arizona | 11/15/08 | 55-45 |
| Oregon St. | California | 11/15/08 | 34-21 |
| Penn St. | Indiana | 11/15/08 | 34-7 |
| Purdue | Iowa | 11/15/08 | 17-22 |
| Rutgers | South Fla. | 11/15/08 | 49-16 |
| San Diego St. | Utah | 11/15/08 | 14-63 |
| San Jose St. | Nevada | 11/15/08 | 17-41 |
| SMU | UTEP | 11/15/08 | 10-36 |
| South Carolina | Florida | 11/15/08 | 6-56 |
| South Fla. | Rutgers | 11/15/08 | 16-49 |
| Southern California | Stanford | 11/15/08 | 45-23 |
| Southern Miss. | East Carolina | 11/15/08 | 21-3 |
| Stanford | Southern California | 11/15/08 | 23-45 |
| Syracuse | Connecticut | 11/15/08 | 14-39 |
| Temple | Kent St. | 11/12/08 | 38-41 |
| Texas | Kansas | 11/15/08 | 35-7 |
| Texas A&M | Baylor | 11/15/08 | 21-41 |
| Toledo | Western Mich. | 11/15/08 | 17-27 |
| Troy | LSU | 11/15/08 | 31-40 |
| Tulane | UAB | 11/15/08 | 24-41 |
| Tulsa | Houston | 11/15/08 | 30-70 |
| UAB | Tulane | 11/15/08 | 41-24 |
| UCF | Marshall | 11/15/08 | 30-14 |
| UCLA | Washington | 11/15/08 | 27-7 |
| UNLV | Wyoming | 11/13/08 | 22-14 |
| Utah | San Diego St. | 11/15/08 | 63-14 |
| Utah St. | Louisiana Tech | 11/15/08 | 38-45 |
| UTEP | SMU | 11/15/08 | 36-10 |
| Vanderbilt | Kentucky | 11/15/08 | 31-24 |
| Virginia Tech | Miami (Fla.) | 11/13/08 | 14-16 |
| Wake Forest | North Carolina St. | 11/15/08 | 17-21 |
| Washington | UCLA | 11/15/08 | 7-27 |
| Washington St. | Arizona St. | 11/15/08 | 0-31 |
| Western Ky. | Middle Tenn. St. | 11/15/08 | 10-21 |
| Western Mich. | Toledo | 11/15/08 | 27-17 |
| Wisconsin | Minnesota | 11/15/08 | 35-32 |
| Wyoming | UNLV | 11/13/08 | 14-22 |