| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Air Force | TCU | 11/22/08 | 10-44 |
| Akron | Ohio | 11/22/08 | 42-49 |
| Arizona | Oregon St. | 11/22/08 | 17-19 |
| Arkansas | Mississippi St. | 11/22/08 | 28-31 |
| Arkansas St. | Fla. Atlantic | 11/22/08 | 28-14 |
| Army | Rutgers | 11/22/08 | 3-30 |
| Ball St. | Central Mich. | 11/19/08 | 31-24 |
| Boise St. | Nevada | 11/22/08 | 41-34 |
| Boston College | Wake Forest | 11/22/08 | 24-21 |
| Bowling Green | Buffalo | 11/21/08 | 34-40 |
| Buffalo | Bowling Green | 11/21/08 | 40-34 |
| BYU | Utah | 11/22/08 | 24-48 |
| California | Stanford | 11/22/08 | 37-16 |
| Central Mich. | Ball St. | 11/19/08 | 24-31 |
| Cincinnati | Pittsburgh | 11/22/08 | 28-21 |
| Clemson | Virginia | 11/22/08 | 13-3 |
| Colorado St. | Wyoming | 11/22/08 | 31-20 |
| Duke | Virginia Tech | 11/22/08 | 3-14 |
| East Carolina | UAB | 11/22/08 | 17-13 |
| Eastern Mich. | Temple | 11/22/08 | 52-55 |
| Fla. Atlantic | Arkansas St. | 11/22/08 | 14-28 |
| Florida | Citadel | 11/22/08 | 70-19 |
| Florida Int'l | La.-Monroe | 11/22/08 | 27-31 |
| Florida St. | Maryland | 11/22/08 | 37-3 |
| Fresno St. | San Jose St. | 11/21/08 | 24-10 |
| Georgia Tech | Miami (Fla.) | 11/20/08 | 41-23 |
| Hawaii | Idaho | 11/22/08 | 49-17 |
| Houston | UTEP | 11/22/08 | 42-37 |
| Idaho | Hawaii | 11/22/08 | 17-49 |
| Illinois | Northwestern | 11/22/08 | 10-27 |
| Indiana | Purdue | 11/22/08 | 10-62 |
| Iowa | Minnesota | 11/22/08 | 55-0 |
| Iowa St. | Kansas St. | 11/22/08 | 30-38 |
| Kansas St. | Iowa St. | 11/22/08 | 38-30 |
| Kent St. | Northern Ill. | 11/18/08 | 14-42 |
| La.-Lafayette | Troy | 11/22/08 | 3-48 |
| La.-Monroe | Florida Int'l | 11/22/08 | 31-27 |
| Louisiana Tech | New Mexico St. | 11/22/08 | 35-31 |
| Louisville | West Virginia | 11/22/08 | 21-35 |
| LSU | Mississippi | 11/22/08 | 13-31 |
| Marshall | Rice | 11/22/08 | 10-35 |
| Maryland | Florida St. | 11/22/08 | 3-37 |
| Memphis | UCF | 11/22/08 | 21-28 |
| Miami (Fla.) | Georgia Tech | 11/20/08 | 23-41 |
| Miami (Ohio) | Toledo | 11/21/08 | 14-42 |
| Michigan | Ohio St. | 11/22/08 | 7-42 |
| Michigan St. | Penn St. | 11/22/08 | 18-49 |
| Middle Tenn. St. | North Texas | 11/22/08 | 52-13 |
| Minnesota | Iowa | 11/22/08 | 0-55 |
| Mississippi | LSU | 11/22/08 | 31-13 |
| Mississippi St. | Arkansas | 11/22/08 | 31-28 |
| Nevada | Boise St. | 11/22/08 | 34-41 |
| New Mexico St. | Louisiana Tech | 11/22/08 | 31-35 |
| North Carolina | North Carolina St. | 11/22/08 | 10-41 |
| North Carolina St. | North Carolina | 11/22/08 | 41-10 |
| North Texas | Middle Tenn. St. | 11/22/08 | 13-52 |
| Northern Ill. | Kent St. | 11/18/08 | 42-14 |
| Northwestern | Illinois | 11/22/08 | 27-10 |
| Notre Dame | Syracuse | 11/22/08 | 23-24 |
| Ohio | Akron | 11/22/08 | 49-42 |
| Ohio St. | Michigan | 11/22/08 | 42-7 |
| Oklahoma | Texas Tech | 11/22/08 | 65-21 |
| Oregon St. | Arizona | 11/22/08 | 19-17 |
| Penn St. | Michigan St. | 11/22/08 | 49-18 |
| Pittsburgh | Cincinnati | 11/22/08 | 21-28 |
| Purdue | Indiana | 11/22/08 | 62-10 |
| Rice | Marshall | 11/22/08 | 35-10 |
| Rutgers | Army | 11/22/08 | 30-3 |
| San Diego St. | UNLV | 11/22/08 | 42-21 |
| San Jose St. | Fresno St. | 11/21/08 | 10-24 |
| Stanford | California | 11/22/08 | 16-37 |
| Syracuse | Notre Dame | 11/22/08 | 24-23 |
| TCU | Air Force | 11/22/08 | 44-10 |
| Temple | Eastern Mich. | 11/22/08 | 55-52 |
| Tennessee | Vanderbilt | 11/22/08 | 20-10 |
| Texas Tech | Oklahoma | 11/22/08 | 21-65 |
| Toledo | Miami (Ohio) | 11/21/08 | 42-14 |
| Troy | La.-Lafayette | 11/22/08 | 48-3 |
| Tulane | Tulsa | 11/22/08 | 7-56 |
| Tulsa | Tulane | 11/22/08 | 56-7 |
| UAB | East Carolina | 11/22/08 | 13-17 |
| UCF | Memphis | 11/22/08 | 28-21 |
| UNLV | San Diego St. | 11/22/08 | 21-42 |
| Utah | BYU | 11/22/08 | 48-24 |
| UTEP | Houston | 11/22/08 | 37-42 |
| Vanderbilt | Tennessee | 11/22/08 | 10-20 |
| Virginia | Clemson | 11/22/08 | 3-13 |
| Virginia Tech | Duke | 11/22/08 | 14-3 |
| Wake Forest | Boston College | 11/22/08 | 21-24 |
| Washington | Washington St. | 11/22/08 | 13-16 |
| Washington St. | Washington | 11/22/08 | 16-13 |
| West Virginia | Louisville | 11/22/08 | 35-21 |
| Wisconsin | Cal Poly | 11/22/08 | 36-35 |
| Wyoming | Colorado St. | 11/22/08 | 20-31 |