| Team | Opponent | Game Date | Score |
|---|---|---|---|
| Akron | Temple | 11/28/08 | 6-27 |
| Alabama | Auburn | 11/29/08 | 36-0 |
| Arizona St. | UCLA | 11/28/08 | 34-9 |
| Arkansas | LSU | 11/28/08 | 31-30 |
| Arkansas St. | North Texas | 11/29/08 | 33-28 |
| Auburn | Alabama | 11/29/08 | 0-36 |
| Ball St. | Western Mich. | 11/25/08 | 45-22 |
| Baylor | Texas Tech | 11/29/08 | 28-35 |
| Boise St. | Fresno St. | 11/28/08 | 61-10 |
| Boston College | Maryland | 11/29/08 | 28-21 |
| Bowling Green | Toledo | 11/28/08 | 38-10 |
| Buffalo | Kent St. | 11/28/08 | 21-24 |
| Central Mich. | Eastern Mich. | 11/28/08 | 52-56 |
| Cincinnati | Syracuse | 11/29/08 | 30-10 |
| Clemson | South Carolina | 11/29/08 | 31-14 |
| Colorado | Nebraska | 11/28/08 | 31-40 |
| Connecticut | South Fla. | 11/23/08 | 13-17 |
| Duke | North Carolina | 11/29/08 | 20-28 |
| East Carolina | UTEP | 11/28/08 | 53-21 |
| Eastern Mich. | Central Mich. | 11/28/08 | 56-52 |
| Fla. Atlantic | Florida Int'l | 11/29/08 | 57-50 |
| Florida | Florida St. | 11/29/08 | 45-15 |
| Florida Int'l | Fla. Atlantic | 11/29/08 | 50-57 |
| Florida St. | Florida | 11/29/08 | 15-45 |
| Fresno St. | Boise St. | 11/28/08 | 10-61 |
| Georgia | Georgia Tech | 11/29/08 | 42-45 |
| Georgia Tech | Georgia | 11/29/08 | 45-42 |
| Hawaii | Washington St. | 11/29/08 | 24-10 |
| Houston | Rice | 11/29/08 | 42-56 |
| Kansas | Missouri | 11/29/08 | 40-37 |
| Kent St. | Buffalo | 11/28/08 | 24-21 |
| Kentucky | Tennessee | 11/29/08 | 10-28 |
| Louisiana Tech | Nevada | 11/29/08 | 31-35 |
| LSU | Arkansas | 11/28/08 | 30-31 |
| Marshall | Tulsa | 11/29/08 | 35-38 |
| Maryland | Boston College | 11/29/08 | 21-28 |
| Memphis | Tulane | 11/29/08 | 45-6 |
| Miami (Fla.) | North Carolina St. | 11/29/08 | 28-38 |
| Miami (Ohio) | Ohio | 11/28/08 | 26-41 |
| Mississippi | Mississippi St. | 11/28/08 | 45-0 |
| Mississippi St. | Mississippi | 11/28/08 | 0-45 |
| Missouri | Kansas | 11/29/08 | 37-40 |
| Navy | Northern Ill. | 11/25/08 | 16-0 |
| Nebraska | Colorado | 11/28/08 | 40-31 |
| Nevada | Louisiana Tech | 11/29/08 | 35-31 |
| New Mexico St. | Utah St. | 11/29/08 | 2-47 |
| North Carolina | Duke | 11/29/08 | 28-20 |
| North Carolina St. | Miami (Fla.) | 11/29/08 | 38-28 |
| North Texas | Arkansas St. | 11/29/08 | 28-33 |
| Northern Ill. | Navy | 11/25/08 | 0-16 |
| Notre Dame | Southern California | 11/29/08 | 3-38 |
| Ohio | Miami (Ohio) | 11/28/08 | 41-26 |
| Oklahoma | Oklahoma St. | 11/29/08 | 61-41 |
| Oklahoma St. | Oklahoma | 11/29/08 | 41-61 |
| Oregon | Oregon St. | 11/29/08 | 65-38 |
| Oregon St. | Oregon | 11/29/08 | 38-65 |
| Pittsburgh | West Virginia | 11/28/08 | 19-15 |
| Rice | Houston | 11/29/08 | 56-42 |
| SMU | Southern Miss. | 11/29/08 | 12-28 |
| South Carolina | Clemson | 11/29/08 | 14-31 |
| South Fla. | Connecticut | 11/23/08 | 17-13 |
| Southern California | Notre Dame | 11/29/08 | 38-3 |
| Southern Miss. | SMU | 11/29/08 | 28-12 |
| Syracuse | Cincinnati | 11/29/08 | 10-30 |
| Temple | Akron | 11/28/08 | 27-6 |
| Tennessee | Kentucky | 11/29/08 | 28-10 |
| Texas | Texas A&M | 11/27/08 | 49-9 |
| Texas A&M | Texas | 11/27/08 | 9-49 |
| Texas Tech | Baylor | 11/29/08 | 35-28 |
| Toledo | Bowling Green | 11/28/08 | 10-38 |
| Tulane | Memphis | 11/29/08 | 6-45 |
| Tulsa | Marshall | 11/29/08 | 38-35 |
| UAB | UCF | 11/29/08 | 15-0 |
| UCF | UAB | 11/29/08 | 0-15 |
| UCLA | Arizona St. | 11/28/08 | 9-34 |
| Utah St. | New Mexico St. | 11/29/08 | 47-2 |
| UTEP | East Carolina | 11/28/08 | 21-53 |
| Vanderbilt | Wake Forest | 11/29/08 | 10-23 |
| Virginia | Virginia Tech | 11/29/08 | 14-17 |
| Virginia Tech | Virginia | 11/29/08 | 17-14 |
| Wake Forest | Vanderbilt | 11/29/08 | 23-10 |
| Washington St. | Hawaii | 11/29/08 | 10-24 |
| West Virginia | Pittsburgh | 11/28/08 | 15-19 |
| Western Mich. | Ball St. | 11/25/08 | 22-45 |